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The map label for this gene is uao [H]

Identifier: 148260154

GI number: 148260154

Start: 1281469

End: 1282011

Strand: Reverse

Name: uao [H]

Synonym: Acry_1150

Alternate gene names: 148260154

Gene position: 1282011-1281469 (Counterclockwise)

Preceding gene: 148260155

Following gene: 148260153

Centisome position: 37.83

GC content: 73.66

Gene sequence:

>543_bases
ATGAGCGCCGACGGCCCCGACATCGCCACCCTGAACGCCATGGCGCGGGAGGATTTCGTCGCAGCACTCGGCGATATCTA
CGAGCATGCCGCGTGGGTCGCCGAGGCGGCCGCGCCGCTGCGCCCCTTCGGCGACCGTGATGCCTTGGCCGCCGCGATGG
CCCGCATCGTCCGCGATGCCGATCCCGCGCTGCAGACGGCACTCCTGCGAGCCCATCCCGAGCTCGGCCATCGTGGCCCG
CTGGCCCCGGAGTCGGCGGACGAGCAGCGGGCGCAGGGCATCGACCGGCTCGCCGCCGGCGAGGCGGCGCGCCTCGCCGC
GCTGAACGCCGCCTATCGGGAACGCTTCGGCTTTCCCTTCATCATCGCCGTGCGCGGCCAGCGCGACATGGCGGCGATCA
TGACGGCGCTGGAACGGCGCCTCGCCGGCACGCCCGATGACGAGCGCCGGATCGCGCTGGCGGAGGTGTGCAGGATCGCC
GGCTTCCGCCTCGCCCGTCGCGTCGCCGCGCCGGCCGACTCCGCGACCGCCTTTTCAGAGTAA

Upstream 100 bases:

>100_bases
AGCAGGCGGTGAGCGCGAAGTCGATGCCGCCCGGCAACGTCACGCACATCACCAGGCGGGAGCGAGAGGAAATCGCCGCC
TGGGTGAGGGGAGGTGCCAA

Downstream 100 bases:

>100_bases
TAGAAACCGGACCCAAACCGGAACCCACAGGAGGACGTCATGACAAACCAGGCCCAGAAAGCGGGCGATACGAAATCGGG
CTTCTCGGTCGAATCCAAGG

Product: hypothetical protein

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSADGPDIATLNAMAREDFVAALGDIYEHAAWVAEAAAPLRPFGDRDALAAAMARIVRDADPALQTALLRAHPELGHRGP
LAPESADEQRAQGIDRLAAGEAARLAALNAAYRERFGFPFIIAVRGQRDMAAIMTALERRLAGTPDDERRIALAEVCRIA
GFRLARRVAAPADSATAFSE

Sequences:

>Translated_180_residues
MSADGPDIATLNAMAREDFVAALGDIYEHAAWVAEAAAPLRPFGDRDALAAAMARIVRDADPALQTALLRAHPELGHRGP
LAPESADEQRAQGIDRLAAGEAARLAALNAAYRERFGFPFIIAVRGQRDMAAIMTALERRLAGTPDDERRIALAEVCRIA
GFRLARRVAAPADSATAFSE
>Mature_179_residues
SADGPDIATLNAMAREDFVAALGDIYEHAAWVAEAAAPLRPFGDRDALAAAMARIVRDADPALQTALLRAHPELGHRGPL
APESADEQRAQGIDRLAAGEAARLAALNAAYRERFGFPFIIAVRGQRDMAAIMTALERRLAGTPDDERRIALAEVCRIAG
FRLARRVAAPADSATAFSE

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3195

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Homo sapiens, GI157743280, Length=163, Percent_Identity=39.2638036809816, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 19215; Mature: 19084

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADGPDIATLNAMAREDFVAALGDIYEHAAWVAEAAAPLRPFGDRDALAAAMARIVRDA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DPALQTALLRAHPELGHRGPLAPESADEQRAQGIDRLAAGEAARLAALNAAYRERFGFPF
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCE
IIAVRGQRDMAAIMTALERRLAGTPDDERRIALAEVCRIAGFRLARRVAAPADSATAFSE
EEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SADGPDIATLNAMAREDFVAALGDIYEHAAWVAEAAAPLRPFGDRDALAAAMARIVRDA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DPALQTALLRAHPELGHRGPLAPESADEQRAQGIDRLAAGEAARLAALNAAYRERFGFPF
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCE
IIAVRGQRDMAAIMTALERRLAGTPDDERRIALAEVCRIAGFRLARRVAAPADSATAFSE
EEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]