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The map label for this gene is guaD [H]

Identifier: 148260152

GI number: 148260152

Start: 1278571

End: 1280031

Strand: Reverse

Name: guaD [H]

Synonym: Acry_1148

Alternate gene names: 148260152

Gene position: 1280031-1278571 (Counterclockwise)

Preceding gene: 148260153

Following gene: 148260149

Centisome position: 37.77

GC content: 69.68

Gene sequence:

>1461_bases
ATGATGATCCCGCCCAGCCCCGGCCGTCTCGCCATCCGCGCTCAGTTGCTCGGCTACGACGGCAATCCCTTCGTGTCGGA
TCCCGCGGACTGCGTGCGGCATGAGAGCGACGGGCTGATCCTCGTCGCGGACGGGCGGATCTCCCATGTCGGTCCCTACG
TCGCCGATCTCGTGCCCGAGGGCGTCGAACTGCATGAGTATCGCGATGCGCTGCTGATGCCGGGCTTCATCGACGCCCAT
GTCCATTACGCGCAGACGCCGATGATCGGCGCCTATGGCAAGCAGCTGCTCGACTGGCTGGAGACCTATGTCTTTCCCGT
CGAGCAGCGCTATGCCGATCCCGATTTTGCCCGCGCCATGGCCCGGCTCTTCTTCGCGCAGGAACTTGCCGCCGGCGTGA
CCACCACGCTGTCCTACTGCACGGTTCATCCCGGCTCGGTCGACGCCTATTTCGAGGAAGCGGCAAGGCTCGGCCTGCGC
GCCGGCGCCGGCAAGGTCCTGATGGACCGCAACGCGCCCGAGCCGCTGCGCGACACCGCACAGCGCGGGTACGACGACTC
CAGGCGCCTGATCGACCGCTGGCATGGCCGCGGCCGGCTGTTCTACGCCGTCACCCCGCGTTTCGCGCCGACCAGCACGC
CGGCCCAGCTTGAGGCGGCCGGCGCGCTGTTCGCCGAGACCGACGGCGTGTGCATGCAGACCCACCTCTCCGAAAACCTC
GCGGAGCTTGATTGGGTGCGCGCCCTGTTCCCCGATGCCCTGGACTACCTCGATGTCTATGATCGCGCGGGGCTGGTGGG
TCCGCGCAGCCTGTTCGGCCATGCCATCCATCTTTCACCCCGCGAATGGGACCGTCTCGCCGGGGCGGGCGCCGCCGTCG
TTCACTGCCCCACCTCGAACCTGTTCCTCGGCTCCGGCCTGTTCGACCTGCGCCGGGCGCTGATCGCCGGCAATCCGGTC
CGCACCGCGCTGGGGTCGGATATCGGCGCCGGAACCAGCTTCTCGCCGCTCGCGACGCTGAACGAGGCGTACAAGGTCGC
GGCCCTGCGGGGCGAGGCGCTCTCCGCCCACCGGGCCTTCTACCTCGCGACCCTCGGCTCGGCGCGAGCCCTGTACATGG
ACGACAGGATCGGTCGCCTCGCGCCGGGGTACGAAGCCGATTTCGCGGTGCTCGACCTCGCCGCCACGCCCCTCCTGCGC
GAGCGTCTGCGTTTCGCCGACACGCTGGAGGAGGCGCTGTTCGTGCTGATGACGCTGGGCGGTGCGGGATGCGTTCGGGC
AACCTACGCGGCGGGCCGCCTCGTGCACGACCGCACCCGGCCCGATGCGTCAGCTCAGGCGGGCGAGGGCTGTTGCGACA
CCGTCGCCGTAGGCCGGATCGGCGCGGCGGCAATTGGCGACGTGCCGCTCCTGGATGTGCCGCGAGGCATCGCCGAGCGC
GCGGGCGGTGTTGTCGAATAG

Upstream 100 bases:

>100_bases
CATCGGCGCGTTCGTCGCCGCGATCGTCTATCTCCTCGCCACCATCCCGCGCACGGCGCCGATCCCGGCGGGTGCTGTGC
CCAGCGCGTAAGGACGCCGC

Downstream 100 bases:

>100_bases
AGCCTGCCGTTGCGTCGGCGTCATCAGGCGGAACAGGTTGCCCGGCTGCTCCCAGTGATCGTCGTCGGCGCGATGATCGT
GATGTGCTGCGTCCCCCTCC

Product: amidohydrolase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MMIPPSPGRLAIRAQLLGYDGNPFVSDPADCVRHESDGLILVADGRISHVGPYVADLVPEGVELHEYRDALLMPGFIDAH
VHYAQTPMIGAYGKQLLDWLETYVFPVEQRYADPDFARAMARLFFAQELAAGVTTTLSYCTVHPGSVDAYFEEAARLGLR
AGAGKVLMDRNAPEPLRDTAQRGYDDSRRLIDRWHGRGRLFYAVTPRFAPTSTPAQLEAAGALFAETDGVCMQTHLSENL
AELDWVRALFPDALDYLDVYDRAGLVGPRSLFGHAIHLSPREWDRLAGAGAAVVHCPTSNLFLGSGLFDLRRALIAGNPV
RTALGSDIGAGTSFSPLATLNEAYKVAALRGEALSAHRAFYLATLGSARALYMDDRIGRLAPGYEADFAVLDLAATPLLR
ERLRFADTLEEALFVLMTLGGAGCVRATYAAGRLVHDRTRPDASAQAGEGCCDTVAVGRIGAAAIGDVPLLDVPRGIAER
AGGVVE

Sequences:

>Translated_486_residues
MMIPPSPGRLAIRAQLLGYDGNPFVSDPADCVRHESDGLILVADGRISHVGPYVADLVPEGVELHEYRDALLMPGFIDAH
VHYAQTPMIGAYGKQLLDWLETYVFPVEQRYADPDFARAMARLFFAQELAAGVTTTLSYCTVHPGSVDAYFEEAARLGLR
AGAGKVLMDRNAPEPLRDTAQRGYDDSRRLIDRWHGRGRLFYAVTPRFAPTSTPAQLEAAGALFAETDGVCMQTHLSENL
AELDWVRALFPDALDYLDVYDRAGLVGPRSLFGHAIHLSPREWDRLAGAGAAVVHCPTSNLFLGSGLFDLRRALIAGNPV
RTALGSDIGAGTSFSPLATLNEAYKVAALRGEALSAHRAFYLATLGSARALYMDDRIGRLAPGYEADFAVLDLAATPLLR
ERLRFADTLEEALFVLMTLGGAGCVRATYAAGRLVHDRTRPDASAQAGEGCCDTVAVGRIGAAAIGDVPLLDVPRGIAER
AGGVVE
>Mature_486_residues
MMIPPSPGRLAIRAQLLGYDGNPFVSDPADCVRHESDGLILVADGRISHVGPYVADLVPEGVELHEYRDALLMPGFIDAH
VHYAQTPMIGAYGKQLLDWLETYVFPVEQRYADPDFARAMARLFFAQELAAGVTTTLSYCTVHPGSVDAYFEEAARLGLR
AGAGKVLMDRNAPEPLRDTAQRGYDDSRRLIDRWHGRGRLFYAVTPRFAPTSTPAQLEAAGALFAETDGVCMQTHLSENL
AELDWVRALFPDALDYLDVYDRAGLVGPRSLFGHAIHLSPREWDRLAGAGAAVVHCPTSNLFLGSGLFDLRRALIAGNPV
RTALGSDIGAGTSFSPLATLNEAYKVAALRGEALSAHRAFYLATLGSARALYMDDRIGRLAPGYEADFAVLDLAATPLLR
ERLRFADTLEEALFVLMTLGGAGCVRATYAAGRLVHDRTRPDASAQAGEGCCDTVAVGRIGAAAIGDVPLLDVPRGIAER
AGGVVE

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=384, Percent_Identity=30.2083333333333, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1789249, Length=420, Percent_Identity=48.8095238095238, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319963, Length=340, Percent_Identity=33.5294117647059, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24643849, Length=376, Percent_Identity=32.1808510638298, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 52308; Mature: 52308

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIPPSPGRLAIRAQLLGYDGNPFVSDPADCVRHESDGLILVADGRISHVGPYVADLVPE
CCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCC
GVELHEYRDALLMPGFIDAHVHYAQTPMIGAYGKQLLDWLETYVFPVEQRYADPDFARAM
CCHHHHHHHHHHCCCHHHHHEEHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHH
ARLFFAQELAAGVTTTLSYCTVHPGSVDAYFEEAARLGLRAGAGKVLMDRNAPEPLRDTA
HHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHH
QRGYDDSRRLIDRWHGRGRLFYAVTPRFAPTSTPAQLEAAGALFAETDGVCMQTHLSENL
HCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCHHEECCCCCEEHHHHHHHH
AELDWVRALFPDALDYLDVYDRAGLVGPRSLFGHAIHLSPREWDRLAGAGAAVVHCPTSN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEECCCHHHHHHCCCCCEEEECCCCC
LFLGSGLFDLRRALIAGNPVRTALGSDIGAGTSFSPLATLNEAYKVAALRGEALSAHRAF
EEECCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHE
YLATLGSARALYMDDRIGRLAPGYEADFAVLDLAATPLLRERLRFADTLEEALFVLMTLG
EEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAGCVRATYAAGRLVHDRTRPDASAQAGEGCCDTVAVGRIGAAAIGDVPLLDVPRGIAER
CCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCHHHHH
AGGVVE
CCCCCC
>Mature Secondary Structure
MMIPPSPGRLAIRAQLLGYDGNPFVSDPADCVRHESDGLILVADGRISHVGPYVADLVPE
CCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCC
GVELHEYRDALLMPGFIDAHVHYAQTPMIGAYGKQLLDWLETYVFPVEQRYADPDFARAM
CCHHHHHHHHHHCCCHHHHHEEHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHH
ARLFFAQELAAGVTTTLSYCTVHPGSVDAYFEEAARLGLRAGAGKVLMDRNAPEPLRDTA
HHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHH
QRGYDDSRRLIDRWHGRGRLFYAVTPRFAPTSTPAQLEAAGALFAETDGVCMQTHLSENL
HCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCHHEECCCCCEEHHHHHHHH
AELDWVRALFPDALDYLDVYDRAGLVGPRSLFGHAIHLSPREWDRLAGAGAAVVHCPTSN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEECCCHHHHHHCCCCCEEEECCCCC
LFLGSGLFDLRRALIAGNPVRTALGSDIGAGTSFSPLATLNEAYKVAALRGEALSAHRAF
EEECCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHE
YLATLGSARALYMDDRIGRLAPGYEADFAVLDLAATPLLRERLRFADTLEEALFVLMTLG
EEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAGCVRATYAAGRLVHDRTRPDASAQAGEGCCDTVAVGRIGAAAIGDVPLLDVPRGIAER
CCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCHHHHH
AGGVVE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]