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The map label for this gene is hcrA [H]

Identifier: 148260129

GI number: 148260129

Start: 1254458

End: 1256722

Strand: Reverse

Name: hcrA [H]

Synonym: Acry_1125

Alternate gene names: 148260129

Gene position: 1256722-1254458 (Counterclockwise)

Preceding gene: 148260133

Following gene: 148260128

Centisome position: 37.08

GC content: 73.02

Gene sequence:

>2265_bases
GTGCCGGCGGACGAGCCGCCGCCGCTGCCGCCGAACGCCGAACTCGCGGTCATCGGCCGTTCGGTTCCCCGGCTGAACGG
GCGCGACAAGGTCACGGGCGCCACGCGCTACACGGTCGACATCGCGCCGCGCGGCATGCTGCATGCCCGCCTGCTGCGCG
CGCCCCTCGCGCATGCCCGCATCCGCGCGATCGACGCCGGCGCGGCCCGCGCGCTCGATGGCGTCCGCGCGGTCGTCATC
CTGGCGCAGCCCGGCGATCCCCTGTCGGGCATGGTCCGCTATGCCGGCCAGCCGGTCGCCGCACTCGCCGCCGACTCGCC
GGCCATCGCCCGCGCGGCGCTCGATCTCGTCCGTGTCGACTACGAAGCGCTCCCCTTCGTCGTCGACATGGAAGACGCCC
GCGCCAGCGAAGCGCCGCCGGTCTATGCCCCCGGCACCGCGCCGGCCGGCCATCCCTCCGGCTTCCCGGCCCCCGCCGGT
CTCGCCCGACACGGCAACGTCCGCGCCGCCGTGATCGACCGGCGGGGCGACGTCGCCGCCGGCCTCGCCGCGGCCGATGT
GGTGGTGGAGGGCACCTATCGCACCCAGGTGCAGACCCATTGCTGCATGGAGCCCCACGCCATCGTCGCGGACTGGACGG
AGGACGGGCTCACCGTCCACATGTCCACCCAGTTCACCGCCGGCATCCGCCACGAACTCGCCGCCGCGTTTCAGCTCCCG
CTCAGCCGCGTGCGCGTCGTGGTCGACGGCATGGGCGGCGGCTTCGGCTCGAAATCGACCCTCGGCACCTATGGGCGCGC
CGCCGTCGCCCTCTCCCGCGCGGCCGGCGCGCCCGTCCGCCTGGTGCTGACCCGCGCCGAGGAGCAGGTCGATTCCGGCA
ACCGCCCCGGCACGTTCCAGCACCTGCGCATCGGCGCCCGGCGCGATGGCACGCTGACCGCGATCGAACTGACCAGCCAT
GGCACGGCGGGCGTGGCGCTCGGCGCCGGCGTCGGCGACTTTGCCGGCGCGGTCTACCGGTGTCCGAACCTGCTGACATC
GCATCGCGACGTCTTCACCAATGCCGGACCCGGCTGCGCCATGCGCGCGCCGGGAAACGTGCCGGGCGCCTTCGCCTTCG
AACAGGCGATCGACGAGCTCGCCGAACGCCTCGCGCTCGATCCCGTTGCCCTGCGCGACAGGATCGATCCCAGCCCGGTC
CGCCGCGAGGAACGGCGGATCGGCGCCGCGCGCTTCGGCTGGGCCGCCCGCCATCCGCCGGGTTCGGATCGGGGGCCGGT
CAAGCGCGGCATCGGCATGGCGCAGTCCCACTGGGGCGCGCATGTGCAGATCAACGCGGCCTGCGAGGTCCGTGTCCTGC
GCGACGGCTCGGTGGAGGTGATGTCGAGCGTGCAGGATATCGGCACCGGCATCACCACGGTGCTCGCCCAGACGGTGGCG
GAAGTCCTCGGCCTGCGCGCGGAGGATATCACGGTCCGCATCGGCGATACCATCTTTCCGTCGGGGCCGCCGTCCTATGG
CAGCCGCACGACGGCGTCGATCACGCCGCCCGCCCGCACCGCCGCCTGGCGCGTGCTCCGCCGCCTGCTGGCCGAAGCCG
CCCAGCGCCTGGGCGTCGCGCCGGATGCCCTGATCGCCCGCGCCGGGCGGATCATCGTCCGCGACGATCCTGCCCGGGGC
CTGGCCTTCGGCGAGGTCACGGCGCGGCTGCGCACGGATTCCATCAGCGAAGTCGCCTCCCGCGCCGACGATTACGCCGG
CTTCGGGCAACGCTACGGCGACGCGGCGACGGCCCGGCAGGATCTCGGCGGCGTGCAGTTCGCCGCCGTCGCGGTCGATA
CCGAAACCGGCATCATCCGGGTCGAGCGCGTGCTCGCCGTCCAGGATTGCGGCCGCCCGATGAACCCGCGTCAGATCGAA
AGCCAGGTTCATGGCGGCATCCTGATGGGCCTGTCCTACGCGCTGTTCGAGGACCGCATCATGGACCGTCACACCGGCCG
CATGGTCAACCCCGATCTCGAGCAATACAAGATCGCCGGACCGTACGAGACCCCCGCGATCGACGTCGTCCTCCTCGAAA
ACTACGAAGCCAACAGCGCAACCGATGCCTACGGCATCGCCGAGCCGGCGAACATCGCCACCGCGCCGGCGATCGCCAAC
GCCGTCCGCAACGCCATCGGCATCCGCATGCGGCGCCTGCCGATGACCCCGGCCGCGGTGCTGGCGGCGCTCGGCGGCTC
TCCGTCCCGGAACCTGCCCCCATGA

Upstream 100 bases:

>100_bases
GTGTACGGAAATCCTGAGCATGGCGCATGATCCGTCACGCCGCACCGAGCGCTTCCCCCACGGCATCGCCGGGGCCGGCC
TCGGGTCGATCGAGCGGTCG

Downstream 100 bases:

>100_bases
AGCCGTTCGCCACGCTCCGCGCCCCGACGATCGCCGCCGCCGCCGCCTCGGCCTCCACGACGATGGCGGAAGCGATGACC
CGCGCCGGCCCGGCGAACGG

Product: molybdopterin binding aldehyde oxidase and xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 754; Mature: 753

Protein sequence:

>754_residues
MPADEPPPLPPNAELAVIGRSVPRLNGRDKVTGATRYTVDIAPRGMLHARLLRAPLAHARIRAIDAGAARALDGVRAVVI
LAQPGDPLSGMVRYAGQPVAALAADSPAIARAALDLVRVDYEALPFVVDMEDARASEAPPVYAPGTAPAGHPSGFPAPAG
LARHGNVRAAVIDRRGDVAAGLAAADVVVEGTYRTQVQTHCCMEPHAIVADWTEDGLTVHMSTQFTAGIRHELAAAFQLP
LSRVRVVVDGMGGGFGSKSTLGTYGRAAVALSRAAGAPVRLVLTRAEEQVDSGNRPGTFQHLRIGARRDGTLTAIELTSH
GTAGVALGAGVGDFAGAVYRCPNLLTSHRDVFTNAGPGCAMRAPGNVPGAFAFEQAIDELAERLALDPVALRDRIDPSPV
RREERRIGAARFGWAARHPPGSDRGPVKRGIGMAQSHWGAHVQINAACEVRVLRDGSVEVMSSVQDIGTGITTVLAQTVA
EVLGLRAEDITVRIGDTIFPSGPPSYGSRTTASITPPARTAAWRVLRRLLAEAAQRLGVAPDALIARAGRIIVRDDPARG
LAFGEVTARLRTDSISEVASRADDYAGFGQRYGDAATARQDLGGVQFAAVAVDTETGIIRVERVLAVQDCGRPMNPRQIE
SQVHGGILMGLSYALFEDRIMDRHTGRMVNPDLEQYKIAGPYETPAIDVVLLENYEANSATDAYGIAEPANIATAPAIAN
AVRNAIGIRMRRLPMTPAAVLAALGGSPSRNLPP

Sequences:

>Translated_754_residues
MPADEPPPLPPNAELAVIGRSVPRLNGRDKVTGATRYTVDIAPRGMLHARLLRAPLAHARIRAIDAGAARALDGVRAVVI
LAQPGDPLSGMVRYAGQPVAALAADSPAIARAALDLVRVDYEALPFVVDMEDARASEAPPVYAPGTAPAGHPSGFPAPAG
LARHGNVRAAVIDRRGDVAAGLAAADVVVEGTYRTQVQTHCCMEPHAIVADWTEDGLTVHMSTQFTAGIRHELAAAFQLP
LSRVRVVVDGMGGGFGSKSTLGTYGRAAVALSRAAGAPVRLVLTRAEEQVDSGNRPGTFQHLRIGARRDGTLTAIELTSH
GTAGVALGAGVGDFAGAVYRCPNLLTSHRDVFTNAGPGCAMRAPGNVPGAFAFEQAIDELAERLALDPVALRDRIDPSPV
RREERRIGAARFGWAARHPPGSDRGPVKRGIGMAQSHWGAHVQINAACEVRVLRDGSVEVMSSVQDIGTGITTVLAQTVA
EVLGLRAEDITVRIGDTIFPSGPPSYGSRTTASITPPARTAAWRVLRRLLAEAAQRLGVAPDALIARAGRIIVRDDPARG
LAFGEVTARLRTDSISEVASRADDYAGFGQRYGDAATARQDLGGVQFAAVAVDTETGIIRVERVLAVQDCGRPMNPRQIE
SQVHGGILMGLSYALFEDRIMDRHTGRMVNPDLEQYKIAGPYETPAIDVVLLENYEANSATDAYGIAEPANIATAPAIAN
AVRNAIGIRMRRLPMTPAAVLAALGGSPSRNLPP
>Mature_753_residues
PADEPPPLPPNAELAVIGRSVPRLNGRDKVTGATRYTVDIAPRGMLHARLLRAPLAHARIRAIDAGAARALDGVRAVVIL
AQPGDPLSGMVRYAGQPVAALAADSPAIARAALDLVRVDYEALPFVVDMEDARASEAPPVYAPGTAPAGHPSGFPAPAGL
ARHGNVRAAVIDRRGDVAAGLAAADVVVEGTYRTQVQTHCCMEPHAIVADWTEDGLTVHMSTQFTAGIRHELAAAFQLPL
SRVRVVVDGMGGGFGSKSTLGTYGRAAVALSRAAGAPVRLVLTRAEEQVDSGNRPGTFQHLRIGARRDGTLTAIELTSHG
TAGVALGAGVGDFAGAVYRCPNLLTSHRDVFTNAGPGCAMRAPGNVPGAFAFEQAIDELAERLALDPVALRDRIDPSPVR
REERRIGAARFGWAARHPPGSDRGPVKRGIGMAQSHWGAHVQINAACEVRVLRDGSVEVMSSVQDIGTGITTVLAQTVAE
VLGLRAEDITVRIGDTIFPSGPPSYGSRTTASITPPARTAAWRVLRRLLAEAAQRLGVAPDALIARAGRIIVRDDPARGL
AFGEVTARLRTDSISEVASRADDYAGFGQRYGDAATARQDLGGVQFAAVAVDTETGIIRVERVLAVQDCGRPMNPRQIES
QVHGGILMGLSYALFEDRIMDRHTGRMVNPDLEQYKIAGPYETPAIDVVLLENYEANSATDAYGIAEPANIATAPAIANA
VRNAIGIRMRRLPMTPAAVLAALGGSPSRNLPP

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To xanthine oxidases [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=693, Percent_Identity=23.3766233766234, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI71773480, Length=803, Percent_Identity=23.0386052303861, Blast_Score=113, Evalue=8e-25,
Organism=Escherichia coli, GI1786478, Length=780, Percent_Identity=32.0512820512821, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1789230, Length=772, Percent_Identity=29.2746113989637, Blast_Score=263, Evalue=3e-71,
Organism=Escherichia coli, GI1789246, Length=805, Percent_Identity=29.3167701863354, Blast_Score=250, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17540638, Length=683, Percent_Identity=23.7188872620791, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737937, Length=735, Percent_Identity=26.9387755102041, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24647199, Length=708, Percent_Identity=23.4463276836158, Blast_Score=114, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017607
- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 79292; Mature: 79161

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADEPPPLPPNAELAVIGRSVPRLNGRDKVTGATRYTVDIAPRGMLHARLLRAPLAHAR
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
IRAIDAGAARALDGVRAVVILAQPGDPLSGMVRYAGQPVAALAADSPAIARAALDLVRVD
EEEECCHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
YEALPFVVDMEDARASEAPPVYAPGTAPAGHPSGFPAPAGLARHGNVRAAVIDRRGDVAA
HHHCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
GLAAADVVVEGTYRTQVQTHCCMEPHAIVADWTEDGLTVHMSTQFTAGIRHELAAAFQLP
HHEEEHEEEECCHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCC
LSRVRVVVDGMGGGFGSKSTLGTYGRAAVALSRAAGAPVRLVLTRAEEQVDSGNRPGTFQ
HHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCCCCCC
HLRIGARRDGTLTAIELTSHGTAGVALGAGVGDFAGAVYRCPNLLTSHRDVFTNAGPGCA
EEEECCCCCCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCE
MRAPGNVPGAFAFEQAIDELAERLALDPVALRDRIDPSPVRREERRIGAARFGWAARHPP
ECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCC
GSDRGPVKRGIGMAQSHWGAHVQINAACEVRVLRDGSVEVMSSVQDIGTGITTVLAQTVA
CCCCCCHHHCCCCHHHCCCCEEEEECEEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHH
EVLGLRAEDITVRIGDTIFPSGPPSYGSRTTASITPPARTAAWRVLRRLLAEAAQRLGVA
HHHCCCCCCEEEEECCEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
PDALIARAGRIIVRDDPARGLAFGEVTARLRTDSISEVASRADDYAGFGQRYGDAATARQ
HHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DLGGVQFAAVAVDTETGIIRVERVLAVQDCGRPMNPRQIESQVHGGILMGLSYALFEDRI
HCCCCEEEEEEEECCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
MDRHTGRMVNPDLEQYKIAGPYETPAIDVVLLENYEANSATDAYGIAEPANIATAPAIAN
HHHHCCCCCCCCHHHEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
AVRNAIGIRMRRLPMTPAAVLAALGGSPSRNLPP
HHHHHHHCCCEECCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PADEPPPLPPNAELAVIGRSVPRLNGRDKVTGATRYTVDIAPRGMLHARLLRAPLAHAR
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
IRAIDAGAARALDGVRAVVILAQPGDPLSGMVRYAGQPVAALAADSPAIARAALDLVRVD
EEEECCHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
YEALPFVVDMEDARASEAPPVYAPGTAPAGHPSGFPAPAGLARHGNVRAAVIDRRGDVAA
HHHCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
GLAAADVVVEGTYRTQVQTHCCMEPHAIVADWTEDGLTVHMSTQFTAGIRHELAAAFQLP
HHEEEHEEEECCHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCC
LSRVRVVVDGMGGGFGSKSTLGTYGRAAVALSRAAGAPVRLVLTRAEEQVDSGNRPGTFQ
HHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCCCCCC
HLRIGARRDGTLTAIELTSHGTAGVALGAGVGDFAGAVYRCPNLLTSHRDVFTNAGPGCA
EEEECCCCCCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCE
MRAPGNVPGAFAFEQAIDELAERLALDPVALRDRIDPSPVRREERRIGAARFGWAARHPP
ECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCC
GSDRGPVKRGIGMAQSHWGAHVQINAACEVRVLRDGSVEVMSSVQDIGTGITTVLAQTVA
CCCCCCHHHCCCCHHHCCCCEEEEECEEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHH
EVLGLRAEDITVRIGDTIFPSGPPSYGSRTTASITPPARTAAWRVLRRLLAEAAQRLGVA
HHHCCCCCCEEEEECCEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
PDALIARAGRIIVRDDPARGLAFGEVTARLRTDSISEVASRADDYAGFGQRYGDAATARQ
HHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DLGGVQFAAVAVDTETGIIRVERVLAVQDCGRPMNPRQIESQVHGGILMGLSYALFEDRI
HCCCCEEEEEEEECCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
MDRHTGRMVNPDLEQYKIAGPYETPAIDVVLLENYEANSATDAYGIAEPANIATAPAIAN
HHHHCCCCCCCCHHHEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
AVRNAIGIRMRRLPMTPAAVLAALGGSPSRNLPP
HHHHHHHCCCEECCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]