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The map label for this gene is aceA [C]

Identifier: 148260097

GI number: 148260097

Start: 1214603

End: 1216198

Strand: Reverse

Name: aceA [C]

Synonym: Acry_1090

Alternate gene names: 148260097

Gene position: 1216198-1214603 (Counterclockwise)

Preceding gene: 148260098

Following gene: 148260095

Centisome position: 35.88

GC content: 66.04

Gene sequence:

>1596_bases
ATGACGTATCAGCAGACGATTGGCACGATGAGCGAAACGATCGCCGCGAAGGGCGCCGCCTGGGAGGGCATCTCGCCCGA
GGCCGTGGCCCGCATGCGGCTGCAGAACCGGTTCCAGACCGGGCTCGACATCGCCCGCCACACCGCGAAGGTCATGCGCC
AGGACATGGCCGCCTTCGATGCCGATCCCTCGCGCTACACCCAGTCGCTCGGCTGCTGGCACGGCTTCATCGCCCAGCAG
AAGATGATCGCGATCAAGAAGCATTTCGGCACCACCAAGGGCCGCTACATCTACCTCTCCGGCTGGATGGTCGCGGCGAT
GCGCTCCGAGTTCGGCCCGCTGCCCGACCAGTCGATGCATGAAAAGACCTCGGTGCCGGCGCTGATCGAGGAGATCTACA
CCTTCCTCCGCCAGGCCGACGCCCGCGAGCTCGGCCTGCTCTTCCGCGAGCTCGACGCCGCCCGCGAGGCCGGCGACCTC
GCGAAGCAGAAGGAGGTGCAGACCCGGATCGACAATTTCGAAACCCATGTCGTGCCGATCATCGCCGATATCGACGCCGG
CTTCGGCAATGCCGAGGCGACCTACCTGCTGGCCAAGAAGATGATCGAGGCCGGCGCCTGCGCGCTGCAGATCGAGAACC
AGGTGTCCGACGAGAAGCAGTGCGGCCACCAGGACGGCAAGGTGACCGTCCCGCACGAGGATTTCGTCCAGAAGATCCGC
GCCCTGCGCTACGCCTTCATGGAGCTCGGCGTCGAGGACGGCGTGATCGTCGCCCGCACCGACTCGCTCGGCGCCGGCCT
GACCAAGCAGATCGCCTATTCGAAGGAGCCGGGCGACATCGGCGACCAGTACAATTCCTTCCTCGACTGCGACGAGGTCG
ATCCCGCGCAGATCGGCAACGGCGACGTGCTGATCACCCGCAACGGCAAGCTGCTGCGCCCGAAGCGCCTGCCCTCCAAC
CTCTACCAGTTCCGTCCCGGCACCGGGGCCGACCGCTGCGTGCTCGACTGCATCAACGCCCTGAACAACGGCGCCGACCT
GATCTGGATCGAGACCGAGAAGCCCCATATCGAGCAGATCGCCTCGATGGTCGATCGCGTGCGCGAGGTCATCCCGAACG
CCAAGCTCGCCTACAACAACTCGCCCTCCTTCAACTGGACGCTGAACTTCCGCCAGCAGGTCTTCGATGCCTGGAAGGAG
CAGGGCAGGGACGTCTCGGCCTTCGACCGCGCCCGGCTGATGAGCGCCGACTACGACGCGTCCGACCTCGCGGCCGAGGC
CGATGAGCGCATCCGCACCTTCCAGCGCGACGCCGCGCGGCGGGCGAACATCTTCCACCACCTCATCACCCTGCCGACCT
ACCACACCGCGGCGCTGTCGACCGACAATCTCGCGAAGGAGTATTTCGGCGAGCAGGGCATGCTCGGCTATGTCGCCGGC
GTGCAGCGCAAGGAAATCCGCCAGGCCATCGCCTGCGTGAAGCACCAGAACATGGCCGGCTCCGACATCGGCGACGATCA
CAAGGAGTATTTCGCCGGCGATGCCGCGCTGAAGGCCGGCGGCGCCCACAACACGATGAACCAGTTCGCGGCCTGA

Upstream 100 bases:

>100_bases
CACATGTTTACGTGAAAACTTCACAAAACCTTCTGACGCGCCGACCCCCGAGGTGTATCTGAATCGCATCACGCGTTTCC
GGATAACAACGAGGGTTCGA

Downstream 100 bases:

>100_bases
TCCGCGGCGGCCCGGCACGCTCCGGGCCGCCATGCCGGCGCGGCGGGCTCAGCCCCGCCCGCCGGGCTCGTCCTCCCGCA
TGACCAGCGCCGCCGCGCGC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTYQQTIGTMSETIAAKGAAWEGISPEAVARMRLQNRFQTGLDIARHTAKVMRQDMAAFDADPSRYTQSLGCWHGFIAQQ
KMIAIKKHFGTTKGRYIYLSGWMVAAMRSEFGPLPDQSMHEKTSVPALIEEIYTFLRQADARELGLLFRELDAAREAGDL
AKQKEVQTRIDNFETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFVQKIR
ALRYAFMELGVEDGVIVARTDSLGAGLTKQIAYSKEPGDIGDQYNSFLDCDEVDPAQIGNGDVLITRNGKLLRPKRLPSN
LYQFRPGTGADRCVLDCINALNNGADLIWIETEKPHIEQIASMVDRVREVIPNAKLAYNNSPSFNWTLNFRQQVFDAWKE
QGRDVSAFDRARLMSADYDASDLAAEADERIRTFQRDAARRANIFHHLITLPTYHTAALSTDNLAKEYFGEQGMLGYVAG
VQRKEIRQAIACVKHQNMAGSDIGDDHKEYFAGDAALKAGGAHNTMNQFAA

Sequences:

>Translated_531_residues
MTYQQTIGTMSETIAAKGAAWEGISPEAVARMRLQNRFQTGLDIARHTAKVMRQDMAAFDADPSRYTQSLGCWHGFIAQQ
KMIAIKKHFGTTKGRYIYLSGWMVAAMRSEFGPLPDQSMHEKTSVPALIEEIYTFLRQADARELGLLFRELDAAREAGDL
AKQKEVQTRIDNFETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFVQKIR
ALRYAFMELGVEDGVIVARTDSLGAGLTKQIAYSKEPGDIGDQYNSFLDCDEVDPAQIGNGDVLITRNGKLLRPKRLPSN
LYQFRPGTGADRCVLDCINALNNGADLIWIETEKPHIEQIASMVDRVREVIPNAKLAYNNSPSFNWTLNFRQQVFDAWKE
QGRDVSAFDRARLMSADYDASDLAAEADERIRTFQRDAARRANIFHHLITLPTYHTAALSTDNLAKEYFGEQGMLGYVAG
VQRKEIRQAIACVKHQNMAGSDIGDDHKEYFAGDAALKAGGAHNTMNQFAA
>Mature_530_residues
TYQQTIGTMSETIAAKGAAWEGISPEAVARMRLQNRFQTGLDIARHTAKVMRQDMAAFDADPSRYTQSLGCWHGFIAQQK
MIAIKKHFGTTKGRYIYLSGWMVAAMRSEFGPLPDQSMHEKTSVPALIEEIYTFLRQADARELGLLFRELDAAREAGDLA
KQKEVQTRIDNFETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFVQKIRA
LRYAFMELGVEDGVIVARTDSLGAGLTKQIAYSKEPGDIGDQYNSFLDCDEVDPAQIGNGDVLITRNGKLLRPKRLPSNL
YQFRPGTGADRCVLDCINALNNGADLIWIETEKPHIEQIASMVDRVREVIPNAKLAYNNSPSFNWTLNFRQQVFDAWKEQ
GRDVSAFDRARLMSADYDASDLAAEADERIRTFQRDAARRANIFHHLITLPTYHTAALSTDNLAKEYFGEQGMLGYVAGV
QRKEIRQAIACVKHQNMAGSDIGDDHKEYFAGDAALKAGGAHNTMNQFAA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=413, Percent_Identity=29.0556900726392, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=28.8135593220339, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=28.8135593220339, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320908, Length=493, Percent_Identity=25.3549695740365, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6325263, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59082; Mature: 58951

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQQTIGTMSETIAAKGAAWEGISPEAVARMRLQNRFQTGLDIARHTAKVMRQDMAAFD
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADPSRYTQSLGCWHGFIAQQKMIAIKKHFGTTKGRYIYLSGWMVAAMRSEFGPLPDQSMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCCCCHHH
EKTSVPALIEEIYTFLRQADARELGLLFRELDAAREAGDLAKQKEVQTRIDNFETHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFVQKIR
EEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHH
ALRYAFMELGVEDGVIVARTDSLGAGLTKQIAYSKEPGDIGDQYNSFLDCDEVDPAQIGN
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCC
GDVLITRNGKLLRPKRLPSNLYQFRPGTGADRCVLDCINALNNGADLIWIETEKPHIEQI
CCEEEECCCCEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
ASMVDRVREVIPNAKLAYNNSPSFNWTLNFRQQVFDAWKEQGRDVSAFDRARLMSADYDA
HHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCH
SDLAAEADERIRTFQRDAARRANIFHHLITLPTYHTAALSTDNLAKEYFGEQGMLGYVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCCHHHHC
VQRKEIRQAIACVKHQNMAGSDIGDDHKEYFAGDAALKAGGAHNTMNQFAA
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
TYQQTIGTMSETIAAKGAAWEGISPEAVARMRLQNRFQTGLDIARHTAKVMRQDMAAFD
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADPSRYTQSLGCWHGFIAQQKMIAIKKHFGTTKGRYIYLSGWMVAAMRSEFGPLPDQSMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCCCCHHH
EKTSVPALIEEIYTFLRQADARELGLLFRELDAAREAGDLAKQKEVQTRIDNFETHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFVQKIR
EEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHH
ALRYAFMELGVEDGVIVARTDSLGAGLTKQIAYSKEPGDIGDQYNSFLDCDEVDPAQIGN
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCC
GDVLITRNGKLLRPKRLPSNLYQFRPGTGADRCVLDCINALNNGADLIWIETEKPHIEQI
CCEEEECCCCEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
ASMVDRVREVIPNAKLAYNNSPSFNWTLNFRQQVFDAWKEQGRDVSAFDRARLMSADYDA
HHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCH
SDLAAEADERIRTFQRDAARRANIFHHLITLPTYHTAALSTDNLAKEYFGEQGMLGYVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCCHHHHC
VQRKEIRQAIACVKHQNMAGSDIGDDHKEYFAGDAALKAGGAHNTMNQFAA
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]