| Definition | Acidiphilium cryptum JF-5 chromosome, complete genome. |
|---|---|
| Accession | NC_009484 |
| Length | 3,389,227 |
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The map label for this gene is topA [H]
Identifier: 148259742
GI number: 148259742
Start: 814685
End: 817360
Strand: Reverse
Name: topA [H]
Synonym: Acry_0729
Alternate gene names: 148259742
Gene position: 817360-814685 (Counterclockwise)
Preceding gene: 148259743
Following gene: 148259740
Centisome position: 24.12
GC content: 69.66
Gene sequence:
>2676_bases ATGAATGCCATCGTCGTCGTTGAATCCCCCGCCAAGGCCAAGACGATCAACAAGTATCTCGGCGACGGATTCACCGTTCT CGCCTCCTTCGGCCATGTCCGCGACCTGCCGCCGAAGGACGGCTCGGTCCGCCCGGACGAGGATTTCGCGATGTCCTGGG AGGAGGACGCCCGCGGCGACCGCCAGGTCGCGGCCATCGCCAAGGCGCTGAAAGGGGCGGACACGCTCTACCTCGCCACC GACCCCGATCGCGAGGGCGAGGCGATCTCCTGGCATGTCCGCGCCATGCTCGAGGCGCGCAACGTGCTCAAGGGCAAGCA GGTCCGCCGCATCACCTTCAACGAGATCACCAAATCGGCGGTGCAGGCCGCCCTCCGCGCCCCGCGCGACCTCGACACCC CGCTGATCGAGGCCTATCTCGCCCGCCGCGCGCTCGATTATCTGGTCGGCTTCACCCTCTCGCCGGTGCTCTGGCGCAAG CTGCCCGGCAGCAAGAGCGCCGGACGCGTGCAGTCGGTCGCGCTGCGGCTGATCTGCGAGCGCGAGGCCGAGATCGAGCT GTTCCGCCCGCGCGAATACTGGACGATCGAGGCCGAGTTCCGCACCCCCGCCGGCGCGCCGTTCCGCGCCCGCCTCACCC ATCTCGACGGCCGCAAGCTCGACCAGTTCGACCTCGCGGACAAGGCGGCGGCCGATGCGGCGAAGGCGGCGGTCGAGCGT GGTGCCTTCAGCGTCGTCTCGATCGAGAAGAAGCGCGTCCGCCGCAACCCGCCGCCGCCCTTCACCACCTCGACCCTGCA GCAGGACGCCTCGCGCAAGCTGCACATGACGGCGCAGGCCATCATGCGCACCGCCCAGCAGCTCTACGAGGGTGTGGAGA TCGGCGGCGAGACGGTCGGCCTGATCACCTATATGCGAACCGACGGCGTGCAGATGGCGCGCGAGGCCATCACCGCCGCC CGCCAGCAGGTGAAGGACGCGTTCGGCGCGAACTACCTGCCCGCCGCCCCGCGCGAATACCAGTCGAAGGCGAAGAACGC GCAGGAGGCCCACGAGGCGATCCGCCCGACCGATTTCACCCTCACCCCCGAGCGCGCCGCCCGCCACCTCTCGCCCGAGC AGGCGCGGCTCTACGAGCTGATCTACAAGCGCGCCCTCGCCTCGCAGATGCAGTCGGCCGAGCTTGACCAGACCACGGTC GAGCTTGCCGATGCCGCCGGCACCACCCTGCGCGCCACCGGCTCGATCCTCGCCTTCGACGGCTTCCTCAAGCTCTACCG CGAGGGGATGGACGAGGACCCGGAGGACGAAACCGCGAGGCTGCTGCCGCCGATGGCGAAATCCGACCCGCTCGCCAGCG GGCCGGTCACCGCCGAGCAGCATTTCACCCAGCCGCCGCCGCGCTATTCCGAGGCCACCCTGGTCAAGCGCATGGAAGAG CTCGGCATCGGCCGCCCCTCGACCTACGCCTCGATTCTCACCGTGCTGCGCGAGCGCAACTATGTGCGGATGGAAAACCG CCGCTTCATCCCCGAGGATCGCGGCCGGCTGGTCACCGCCTTCCTGGTCAGCTTCTTCGGCCGCTATGTCGAGACCGGCT TCACCGCCGATCTCGAGGAGAAGCTCGACGAGGTCTCCGACGGACGGCTCGACTGGCGGTCGGTGATGCGGGATTTCTGG GCAGATTTCTCTGGCGCCGTCGAGCAGATCAAGGATCTCAAGATCTCCGACGTGATCGATGCGCTGGACGAGGAGCTCGG CCCGCATTTCTTCCCCGCCCGCGAGGACGGGTCCGATCCACGCGTCTGCCAGGCCTGCGGCACCGGCCGGCTCGGCCTGC GGCTCGGCCGCTTCGGCGCCTTCATCGGCTGCTCGAACTATCCCGAATGCCAGTATACCCGCCGCCTCGCCGTCGAGGGC GGCGAGGACGAGGGCGACCAGCTGCGCGACGGCATGAAGCTGCTCGGCGAGAACGCCGAGGGCATCCCCGTCACGCTGCG GCGCGGCCCCTATGGCCTCTATGTCCAGCTCGGCGAGCCGGACCCGGAGGACAAGAAGGCGAAGCCCCGCCGCGCCGCCC TGCCGCGGGGCATGAGCGGCGAGACGATCACGCTGGAGCAGGCGATCGGCCTGCTCTCGCTGCCGCGCGTGATCGGCGTG CATCCGGAAACGAAACAGGAAATCCAGGCCGGCATCGGCCGGTTCGGCCCCTATGTGAAGATGGGCCCCATCTTCGCCTC GCTCGACAAGGATGACGACGTGCTCGCCGTCGGCCTCAACCGCGCGGTGATGGTGCTGGCGAAGAAGCAGGAAGGCATCC GCGATCTCGGCCCGCACCCGAAGGACGGCGAGAGCGTGACCGCGCGCAAGGGCCGGTTCGGCCCCTATGTCCAGCACGGC AAGACGGTGGCGACCCTGCCGCGCGGCAGCGAACTCGGCGCGGTGACCCTTGATGAGGCTGTCGCCCTGCTCGCCGAGAA GGGCAAGACGCTGGCGCCGCGCGGCCGCAAGGGCGCAAAACCCGCAGCAAAGCCGAAGGACGCGGCGGCGCCGAAAGCCG CCAGACCCGCGAAGGCGAAAGCTGCCGCCAAGCCGAAAGCCGCCGCCGCGAAGCCGGAGGCGGCCGCCGCCAAGGCAAAA CCCGCCGCCCGGAAGACCGCCCGCTCCGGCGGCTGA
Upstream 100 bases:
>100_bases CGCCGTGCTGACCGAGCTCGAACTTGCCGGCCGGATCGAAACCCTGCCGGGCAACCGGGTCTGTCTGCTCTCCGAGTGCT GAACGGGATACCGCGCTTAC
Downstream 100 bases:
>100_bases GCCGCCCGCTTCCTATTCCGCAGCCGGGCCGGGCCGGACGATCCGCCCGCCCGCGAGCGGCGCGGGCACGCCGGTCGTCT CCGGCAACGAGAGCGGCAGC
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 891; Mature: 891
Protein sequence:
>891_residues MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLAT DPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRK LPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVER GAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAA RQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTV ELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEE LGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFW ADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEG GEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGV HPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHG KTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAK PAARKTARSGG
Sequences:
>Translated_891_residues MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLAT DPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRK LPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVER GAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAA RQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTV ELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEE LGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFW ADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEG GEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGV HPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHG KTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAK PAARKTARSGG >Mature_891_residues MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLAT DPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRK LPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVER GAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAA RQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTV ELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEE LGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFW ADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEG GEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGV HPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHG KTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAK PAARKTARSGG
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=601, Percent_Identity=26.2895174708819, Blast_Score=133, Evalue=9e-31, Organism=Homo sapiens, GI4507635, Length=633, Percent_Identity=24.6445497630332, Blast_Score=111, Evalue=2e-24, Organism=Escherichia coli, GI1787529, Length=701, Percent_Identity=38.2310984308131, Blast_Score=436, Evalue=1e-123, Organism=Escherichia coli, GI1788061, Length=629, Percent_Identity=25.7551669316375, Blast_Score=132, Evalue=8e-32, Organism=Caenorhabditis elegans, GI32563869, Length=559, Percent_Identity=25.7602862254025, Blast_Score=117, Evalue=3e-26, Organism=Caenorhabditis elegans, GI17555378, Length=507, Percent_Identity=27.0216962524655, Blast_Score=112, Evalue=7e-25, Organism=Saccharomyces cerevisiae, GI6323263, Length=490, Percent_Identity=25.1020408163265, Blast_Score=104, Evalue=6e-23, Organism=Drosophila melanogaster, GI24585251, Length=625, Percent_Identity=25.76, Blast_Score=134, Evalue=4e-31, Organism=Drosophila melanogaster, GI24640096, Length=620, Percent_Identity=23.2258064516129, Blast_Score=94, Evalue=6e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 97524; Mature: 97524
Theoretical pI: Translated: 9.47; Mature: 9.47
Prosite motif: PS00396 TOPOISOMERASE_I_PROK ; PS00223 ANNEXIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGD CCEEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHCCCH RQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSA HHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH VQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICE HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH REAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVER CCCCEEEECCCEEEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH GAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVG CCEEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE LITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFT EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCCE LTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFD ECHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHH GFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEE HHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHH LGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEE HCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH KLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDP HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCC RVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAE HHHHHCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC GIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGV CCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCC HPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHP CCCHHHHHHHHHHHCCCCEEECCEEEECCCCCCEEEEECCCEEEEEEHHHCCHHHCCCCC KDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAK CCCCCEECCCCCCCCHHHCCCEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCC PAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAKPAARKTARSGG CCCCCCCCCCCCCCCCCHHHHHCCCCHHCCCCHHHHHHCCHHHHHHHCCCC >Mature Secondary Structure MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGD CCEEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHCCCH RQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSA HHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH VQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICE HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH REAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVER CCCCEEEECCCEEEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH GAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVG CCEEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE LITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFT EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCCE LTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFD ECHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHH GFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEE HHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHH LGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEE HCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH KLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDP HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCC RVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAE HHHHHCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC GIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGV CCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCC HPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHP CCCHHHHHHHHHHHCCCCEEECCEEEECCCCCCEEEEECCCEEEEEEHHHCCHHHCCCCC KDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAK CCCCCEECCCCCCCCHHHCCCEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCC PAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAKPAARKTARSGG CCCCCCCCCCCCCCCCCHHHHHCCCCHHCCCCHHHHHHCCHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11557893 [H]