Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 148259739

GI number: 148259739

Start: 810959

End: 812212

Strand: Reverse

Name: tyrS [H]

Synonym: Acry_0726

Alternate gene names: 148259739

Gene position: 812212-810959 (Counterclockwise)

Preceding gene: 148259740

Following gene: 148259738

Centisome position: 23.96

GC content: 68.98

Gene sequence:

>1254_bases
ATGCTCATGACCGATCCCGGCGATTTCCTGCACGAGGCAGAAGCGCGCGGCTACATCTTCCAGTGCACCGACACCGAGGG
GCTGCGCGAGGCGATGCGCGCCGGCCCCATCGCCGGCTATATCGGCTTCGACTGCACGGCCGACAGCCTGCATGTCGGCC
ACATGATCCAGATCATGATGCTCCGACTGCTGCAGAAGCACGGGCACAAGCCGGTCGCCATCCTCGGCGGCGGCACCACC
CGCATCGGCGACCCCTCCTTCCGCGAGGAAGCCCGCCAGCTCCTCACCGAGGAGCAGATCGCGCTCAACATGGCCGGCAT
CCGCGACAACATCGCCGCCTATCTGCGCTTCGGCGAGGGCCCGTCCGACGCCATCATGGTCAACAATGCCGACTGGCTGG
ACACGCTCGGCTATATCGACCTGCTGCGCGAGGTCGGCGTGCATTTCAGCGTCAACCGCATGCTGTCCTTCGACTCGGTC
CGCTCGCGGCTGGAGCGCGAACAGGGCCTCACCTTCCTCGAATTCAACTACTCGATCCTGCAGGCCTACGATTTCCGCGA
GCTCAACCGCCGCTATGGCGTGGTGCTGCAAATGGGCGGGTCGGACCAGTGGGGCAACATCGTCCAGGGCATCGACCTCG
TCCGCCGCACCGACGGCAAGCAGGTCTATGGCCTGACCGCGCCGCTGATCACCACCGCCTCGGGCGCGAAGATGGGCAAG
ACCGCCGCCGGCGCCGTCTGGCTCTCGGCCGCGAGGCGCAGCCCGTTCGACTACTGGCAGTTCTGGCGCAACACCGAGGA
TGCCGATGTCGGCCGCTTCCTCCGCCTGTTCACCGACCTGCCGCTCGACGAGATCGCCCGGCTCGAGGCGCTGCAAGGCG
CCGAGATCAACGAGGCGAAGAAGATCCTCGCCACCGAGGCGACCGCGCTCTGCCACGGGCGCGCGGTGGCCGAGGAAGCC
GCGGAGACCGCGCGCCGCACCTTCGAGGGCGGCGAGGCGGCGGAAACCCTGCCGGGGATCGACATCCCCGCCGCCGAGCT
TGAAGCCGGCATTCCCGCCTTCGCCCTGCTGGTGAAAGCCGGGCTCGCCGCCAGCAATGGCGAGGCGCGCCGGCTGATCC
GCGGCGGCGGCGCGCGGCTGAACGACGCCCCGATCGCCGACGAGGCGCACACGATCACCCTCGCCGACGTGATCGACGGC
GCGGCCAAGCTCTCGGCCGGCAAGAAGCACCACCGCCTGGTGCGCCCGGCATGA

Upstream 100 bases:

>100_bases
CGCGCGCCCGGCGGAATTGGCACGCCGGCCCCCGCGTGCTACCCCGCGCCGATCTGAAGACCAACGGGCCGATTGCGGCC
ACCCCGATCACGGCGGAACC

Downstream 100 bases:

>100_bases
GCGCGCCGCCCTTCGTCACCCCCGCGCAGGAGAGCGCCGCCGCGGCGATCGCCGCCCTGCACGACGAGCTGTTCCTGTTC
GATGACTGGATGGACCGCTA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLMTDPGDFLHEAEARGYIFQCTDTEGLREAMRAGPIAGYIGFDCTADSLHVGHMIQIMMLRLLQKHGHKPVAILGGGTT
RIGDPSFREEARQLLTEEQIALNMAGIRDNIAAYLRFGEGPSDAIMVNNADWLDTLGYIDLLREVGVHFSVNRMLSFDSV
RSRLEREQGLTFLEFNYSILQAYDFRELNRRYGVVLQMGGSDQWGNIVQGIDLVRRTDGKQVYGLTAPLITTASGAKMGK
TAAGAVWLSAARRSPFDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALQGAEINEAKKILATEATALCHGRAVAEEA
AETARRTFEGGEAAETLPGIDIPAAELEAGIPAFALLVKAGLAASNGEARRLIRGGGARLNDAPIADEAHTITLADVIDG
AAKLSAGKKHHRLVRPA

Sequences:

>Translated_417_residues
MLMTDPGDFLHEAEARGYIFQCTDTEGLREAMRAGPIAGYIGFDCTADSLHVGHMIQIMMLRLLQKHGHKPVAILGGGTT
RIGDPSFREEARQLLTEEQIALNMAGIRDNIAAYLRFGEGPSDAIMVNNADWLDTLGYIDLLREVGVHFSVNRMLSFDSV
RSRLEREQGLTFLEFNYSILQAYDFRELNRRYGVVLQMGGSDQWGNIVQGIDLVRRTDGKQVYGLTAPLITTASGAKMGK
TAAGAVWLSAARRSPFDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALQGAEINEAKKILATEATALCHGRAVAEEA
AETARRTFEGGEAAETLPGIDIPAAELEAGIPAFALLVKAGLAASNGEARRLIRGGGARLNDAPIADEAHTITLADVIDG
AAKLSAGKKHHRLVRPA
>Mature_417_residues
MLMTDPGDFLHEAEARGYIFQCTDTEGLREAMRAGPIAGYIGFDCTADSLHVGHMIQIMMLRLLQKHGHKPVAILGGGTT
RIGDPSFREEARQLLTEEQIALNMAGIRDNIAAYLRFGEGPSDAIMVNNADWLDTLGYIDLLREVGVHFSVNRMLSFDSV
RSRLEREQGLTFLEFNYSILQAYDFRELNRRYGVVLQMGGSDQWGNIVQGIDLVRRTDGKQVYGLTAPLITTASGAKMGK
TAAGAVWLSAARRSPFDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALQGAEINEAKKILATEATALCHGRAVAEEA
AETARRTFEGGEAAETLPGIDIPAAELEAGIPAFALLVKAGLAASNGEARRLIRGGGARLNDAPIADEAHTITLADVIDG
AAKLSAGKKHHRLVRPA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=401, Percent_Identity=35.1620947630923, Blast_Score=222, Evalue=5e-58,
Organism=Escherichia coli, GI1787925, Length=417, Percent_Identity=43.1654676258993, Blast_Score=340, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI25145802, Length=334, Percent_Identity=32.3353293413174, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25145805, Length=329, Percent_Identity=28.5714285714286, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6325160, Length=403, Percent_Identity=32.7543424317618, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20130383, Length=435, Percent_Identity=36.3218390804598, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45520; Mature: 45520

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMTDPGDFLHEAEARGYIFQCTDTEGLREAMRAGPIAGYIGFDCTADSLHVGHMIQIMM
CCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHH
LRLLQKHGHKPVAILGGGTTRIGDPSFREEARQLLTEEQIALNMAGIRDNIAAYLRFGEG
HHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
PSDAIMVNNADWLDTLGYIDLLREVGVHFSVNRMLSFDSVRSRLEREQGLTFLEFNYSIL
CCCEEEECCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEECHHHH
QAYDFRELNRRYGVVLQMGGSDQWGNIVQGIDLVRRTDGKQVYGLTAPLITTASGAKMGK
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCC
TAAGAVWLSAARRSPFDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALQGAEINEAK
HHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
KILATEATALCHGRAVAEEAAETARRTFEGGEAAETLPGIDIPAAELEAGIPAFALLVKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHCCCHHHHHHHHH
GLAASNGEARRLIRGGGARLNDAPIADEAHTITLADVIDGAAKLSAGKKHHRLVRPA
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure
MLMTDPGDFLHEAEARGYIFQCTDTEGLREAMRAGPIAGYIGFDCTADSLHVGHMIQIMM
CCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHH
LRLLQKHGHKPVAILGGGTTRIGDPSFREEARQLLTEEQIALNMAGIRDNIAAYLRFGEG
HHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
PSDAIMVNNADWLDTLGYIDLLREVGVHFSVNRMLSFDSVRSRLEREQGLTFLEFNYSIL
CCCEEEECCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEECHHHH
QAYDFRELNRRYGVVLQMGGSDQWGNIVQGIDLVRRTDGKQVYGLTAPLITTASGAKMGK
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCC
TAAGAVWLSAARRSPFDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALQGAEINEAK
HHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
KILATEATALCHGRAVAEEAAETARRTFEGGEAAETLPGIDIPAAELEAGIPAFALLVKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHCCCHHHHHHHHH
GLAASNGEARRLIRGGGARLNDAPIADEAHTITLADVIDGAAKLSAGKKHHRLVRPA
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA