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The map label for this gene is panB [H]

Identifier: 148259678

GI number: 148259678

Start: 752071

End: 752883

Strand: Reverse

Name: panB [H]

Synonym: Acry_0665

Alternate gene names: 148259678

Gene position: 752883-752071 (Counterclockwise)

Preceding gene: 148259679

Following gene: 148259666

Centisome position: 22.21

GC content: 70.23

Gene sequence:

>813_bases
ATGGCGATGGAAACGGCAGATCGGAAGGCCGACCGCAAATCGATCGGATCGTGGGAACGCGCGAAGCGCAACGGCGAGCG
CCGCGCGCTGATCACCGCCTATGATTATCCGTTCGCGAAACTCGCCGAGGCCGCCGGGATCGACGGCATCCTGATCGGCG
ATTCGCTGGGAATGACCGTCCAGGGCGAGCGCGACACGCTGCGGGTGACGCTGGAGCAGATGGTCTATCACACCGGCATG
GTCGCGCGCGGCGCGCCCGCCTGCCTGATCATGGCCGACCTGCCCTTCGGCAGTTTCGAGGCCGGCCCTGCCCAGGCCTT
CGCGAGCGCCGCCCAGTTGCTCAAGGCGGGGGCGGACATCGTCAAGCTCGAGGGCGGGGCGGCGATGGTCGAGACCGTCG
GCTTCCTTTCCGCCCGCGCCGTGCCCGTCTGCGCGCATATCGGCCTGACGCCGCAGCATGTCCGCCAGCTCGGCGGCTTC
CGCAAGCAGGGCAAGACCGAGGACGCGGCGGCGCGAATGATCGAGGACGCCGCCGCCCTCGCCGAGGCCGGCGCGCGGAT
GGTGCTGATGGAAGCGATCCCGGCCGGACTCGGGGCCGAGATCACCAGGCGGGTGCGCGTGCCCACCATCGGCATCGGCG
CCGGCAACGGGACCGACGCGCAGATCCTGGTGATGCACGACGTGCTGGGGCTGACCGGCGGCTATGTTCCGGGCTTCGCC
AAGGTGTATGCCGACGGGGCGCGGATGGTGCGCGAGGCGATCGGCGCCTATGCCGAAGAGGTCCGCACCGGCATCTTCCC
GCCCGCCGAATAG

Upstream 100 bases:

>100_bases
GCGGCACGCTGCGCGAGGTGACGGCGGAGGGCGAGCGGCTGATCACCGAGGGCGCGGGCTGAGCCCGAGCGCGCGCAGGC
ACGCCCCAGCACAGAAAGGC

Downstream 100 bases:

>100_bases
GCCTCGAACAGCCGGCCGGGATCCTCCGATCCGGCGGGCAGGAGCGGAACCGGGCGATTGGCGGCCGGTTCAGCGGCCCT
GCTGCGGGATCTCGATATAG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAMETADRKADRKSIGSWERAKRNGERRALITAYDYPFAKLAEAAGIDGILIGDSLGMTVQGERDTLRVTLEQMVYHTGM
VARGAPACLIMADLPFGSFEAGPAQAFASAAQLLKAGADIVKLEGGAAMVETVGFLSARAVPVCAHIGLTPQHVRQLGGF
RKQGKTEDAAARMIEDAAALAEAGARMVLMEAIPAGLGAEITRRVRVPTIGIGAGNGTDAQILVMHDVLGLTGGYVPGFA
KVYADGARMVREAIGAYAEEVRTGIFPPAE

Sequences:

>Translated_270_residues
MAMETADRKADRKSIGSWERAKRNGERRALITAYDYPFAKLAEAAGIDGILIGDSLGMTVQGERDTLRVTLEQMVYHTGM
VARGAPACLIMADLPFGSFEAGPAQAFASAAQLLKAGADIVKLEGGAAMVETVGFLSARAVPVCAHIGLTPQHVRQLGGF
RKQGKTEDAAARMIEDAAALAEAGARMVLMEAIPAGLGAEITRRVRVPTIGIGAGNGTDAQILVMHDVLGLTGGYVPGFA
KVYADGARMVREAIGAYAEEVRTGIFPPAE
>Mature_269_residues
AMETADRKADRKSIGSWERAKRNGERRALITAYDYPFAKLAEAAGIDGILIGDSLGMTVQGERDTLRVTLEQMVYHTGMV
ARGAPACLIMADLPFGSFEAGPAQAFASAAQLLKAGADIVKLEGGAAMVETVGFLSARAVPVCAHIGLTPQHVRQLGGFR
KQGKTEDAAARMIEDAAALAEAGARMVLMEAIPAGLGAEITRRVRVPTIGIGAGNGTDAQILVMHDVLGLTGGYVPGFAK
VYADGARMVREAIGAYAEEVRTGIFPPAE

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=49.8054474708171, Blast_Score=260, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6319653, Length=273, Percent_Identity=34.0659340659341, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28299; Mature: 28168

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMETADRKADRKSIGSWERAKRNGERRALITAYDYPFAKLAEAAGIDGILIGDSLGMTV
CCCCCCHHHHHHHHCCCHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEEEECCCCCEE
QGERDTLRVTLEQMVYHTGMVARGAPACLIMADLPFGSFEAGPAQAFASAAQLLKAGADI
ECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCE
VKLEGGAAMVETVGFLSARAVPVCAHIGLTPQHVRQLGGFRKQGKTEDAAARMIEDAAAL
EEECCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
AEAGARMVLMEAIPAGLGAEITRRVRVPTIGIGAGNGTDAQILVMHDVLGLTGGYVPGFA
HHCCCCEEHHHHCCCCCCHHHHHEEECCEEEEECCCCCCCEEEEEHHHHHHCCCCCCHHH
KVYADGARMVREAIGAYAEEVRTGIFPPAE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AMETADRKADRKSIGSWERAKRNGERRALITAYDYPFAKLAEAAGIDGILIGDSLGMTV
CCCCCHHHHHHHHCCCHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEEEECCCCCEE
QGERDTLRVTLEQMVYHTGMVARGAPACLIMADLPFGSFEAGPAQAFASAAQLLKAGADI
ECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCE
VKLEGGAAMVETVGFLSARAVPVCAHIGLTPQHVRQLGGFRKQGKTEDAAARMIEDAAAL
EEECCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
AEAGARMVLMEAIPAGLGAEITRRVRVPTIGIGAGNGTDAQILVMHDVLGLTGGYVPGFA
HHCCCCEEHHHHCCCCCCHHHHHEEECCEEEEECCCCCCCEEEEEHHHHHHCCCCCCHHH
KVYADGARMVREAIGAYAEEVRTGIFPPAE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA