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The map label for this gene is rfbD [C]

Identifier: 148259625

GI number: 148259625

Start: 685864

End: 686769

Strand: Reverse

Name: rfbD [C]

Synonym: Acry_0611

Alternate gene names: 148259625

Gene position: 686769-685864 (Counterclockwise)

Preceding gene: 148259626

Following gene: 148259601

Centisome position: 20.26

GC content: 74.17

Gene sequence:

>906_bases
ATGCCGCCCCGCCCGATCCTGATCACCGGGGCGAGCGGCCAGCTCGGCCACGCCCTCGCCGCCCGCGCGCCCGCCGCCGG
GCTCCCCGCCCGCGCCATCGGCCGCCCCGGCTTCGACTTCGACGCCCCGGAAACGATCGCCAGGGCCCTCGCCGCCGCCG
ATCCCGCCCTCGTCGTCAACGCCGCCGCCTGGACCGCCGTCGACGCCGCCGAGACCAGCGCCGACGCCGCCTTCCGCGCC
AACCGCGACGGCCCCGCAACCCTCGCCACCCTCTGCCGCGCCCGCGGCATCCCCCTCATCCACGTCTCGACCGACTATGT
CTTCGACGGCACCAAGGGCGCGCCCTACACCGAAACCGACCCGATCGCCCCGCTCGGCGTCTACGGCCACAGCAAGGCCG
CCGGCGAGGAAGCCATCCTCGCCGCCGGCGCCGACGCCATCATCCTCCGCACCGCCTGGGTCTTCTCCGCCACCGGCAAG
AACTTCGCCCGCACCATGATCGCCGCCGCCCGCCGCCTGCCGGCGCTGCGCGTCGTCGCCGACCAGCGCGGCACCCCCAC
CGCCGCCGAAGACCTCGCCGACGCCATCCTCGCCATCGCCGCTCGCATCCTCGCCGAAGGCTGGCAGCCCGGCTTCGCCG
GCATCTTCCACGCCACCAGCGCCGGCGACACCTCATGGCACGGCTTCGCCACCGAAATCCTCGCCCTCGCCGCTCGCCAC
GGCACACCACACCCCGACATCATCCCCATCGCCACCGCAGACTGGCCCACCCCAGCCCGCCGACCCGCCGACTCCCGCCT
CGACACCACAAAACTCAGCCAAACCTTCGCCCTCGCCCTCCCACACTGGAAAGACGCCACCGCCCGCATCGTCCCCGCAA
TCCTCGCGCAGGACGAAACACCGTGA

Upstream 100 bases:

>100_bases
GCCCTGCCCTGGCCCGTCCCCGCCGGCACCGCCCTCCTCTCCGACAAGGACAATCTCCTGCCCCGCCTGGCCGAGGCCGA
ACCCTGGTTCAGGCTCTGAC

Downstream 100 bases:

>100_bases
TCACCATCCTCGACAGACCGTATTGTTCGGCGCGGCGCGACTCTCGGAATGCCCGCCGGCACCGAAATTCCGTGCCGTCA
TTCACGCGTTTCAGCCCGTG

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MPPRPILITGASGQLGHALAARAPAAGLPARAIGRPGFDFDAPETIARALAAADPALVVNAAAWTAVDAAETSADAAFRA
NRDGPATLATLCRARGIPLIHVSTDYVFDGTKGAPYTETDPIAPLGVYGHSKAAGEEAILAAGADAIILRTAWVFSATGK
NFARTMIAAARRLPALRVVADQRGTPTAAEDLADAILAIAARILAEGWQPGFAGIFHATSAGDTSWHGFATEILALAARH
GTPHPDIIPIATADWPTPARRPADSRLDTTKLSQTFALALPHWKDATARIVPAILAQDETP

Sequences:

>Translated_301_residues
MPPRPILITGASGQLGHALAARAPAAGLPARAIGRPGFDFDAPETIARALAAADPALVVNAAAWTAVDAAETSADAAFRA
NRDGPATLATLCRARGIPLIHVSTDYVFDGTKGAPYTETDPIAPLGVYGHSKAAGEEAILAAGADAIILRTAWVFSATGK
NFARTMIAAARRLPALRVVADQRGTPTAAEDLADAILAIAARILAEGWQPGFAGIFHATSAGDTSWHGFATEILALAARH
GTPHPDIIPIATADWPTPARRPADSRLDTTKLSQTFALALPHWKDATARIVPAILAQDETP
>Mature_300_residues
PPRPILITGASGQLGHALAARAPAAGLPARAIGRPGFDFDAPETIARALAAADPALVVNAAAWTAVDAAETSADAAFRAN
RDGPATLATLCRARGIPLIHVSTDYVFDGTKGAPYTETDPIAPLGVYGHSKAAGEEAILAAGADAIILRTAWVFSATGKN
FARTMIAAARRLPALRVVADQRGTPTAAEDLADAILAIAARILAEGWQPGFAGIFHATSAGDTSWHGFATEILALAARHG
TPHPDIIPIATADWPTPARRPADSRLDTTKLSQTFALALPHWKDATARIVPAILAQDETP

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=286, Percent_Identity=30.4195804195804, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI11034825, Length=286, Percent_Identity=30.4195804195804, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1788352, Length=295, Percent_Identity=39.6610169491525, Blast_Score=196, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31153; Mature: 31021

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRPILITGASGQLGHALAARAPAAGLPARAIGRPGFDFDAPETIARALAAADPALVVN
CCCCCEEEECCCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
AAAWTAVDAAETSADAAFRANRDGPATLATLCRARGIPLIHVSTDYVFDGTKGAPYTETD
CHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCCC
PIAPLGVYGHSKAAGEEAILAAGADAIILRTAWVFSATGKNFARTMIAAARRLPALRVVA
CCCEEECCCCCCCCCCCEEEECCCCEEEEEHHHHEECCCHHHHHHHHHHHHHCCEEEEEE
DQRGTPTAAEDLADAILAIAARILAEGWQPGFAGIFHATSAGDTSWHGFATEILALAARH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHC
GTPHPDIIPIATADWPTPARRPADSRLDTTKLSQTFALALPHWKDATARIVPAILAQDET
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCC
P
C
>Mature Secondary Structure 
PPRPILITGASGQLGHALAARAPAAGLPARAIGRPGFDFDAPETIARALAAADPALVVN
CCCCEEEECCCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
AAAWTAVDAAETSADAAFRANRDGPATLATLCRARGIPLIHVSTDYVFDGTKGAPYTETD
CHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCCC
PIAPLGVYGHSKAAGEEAILAAGADAIILRTAWVFSATGKNFARTMIAAARRLPALRVVA
CCCEEECCCCCCCCCCCEEEECCCCEEEEEHHHHEECCCHHHHHHHHHHHHHCCEEEEEE
DQRGTPTAAEDLADAILAIAARILAEGWQPGFAGIFHATSAGDTSWHGFATEILALAARH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHC
GTPHPDIIPIATADWPTPARRPADSRLDTTKLSQTFALALPHWKDATARIVPAILAQDET
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]