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The map label for this gene is qor [C]

Identifier: 148259446

GI number: 148259446

Start: 483455

End: 484462

Strand: Reverse

Name: qor [C]

Synonym: Acry_0429

Alternate gene names: 148259446

Gene position: 484462-483455 (Counterclockwise)

Preceding gene: 148259447

Following gene: 148259445

Centisome position: 14.29

GC content: 62.6

Gene sequence:

>1008_bases
ATGAAAGCTGTCGCCTTCACTCACTCTCTGCCAGTCACTGCCGACGAGGCGCTGATCGATATCGAGGCACCCGATCCGGT
ATTGCGGACTCACGACGTTCTCGTCGAGGTTCGCGCCGTGTCGGTGAACCCGGTAGACACCAAGATCCGGCGGCGTAACG
AACCGCTCGGCGAGCCCCGCATCCTCGGCTTCGATGCCGCTGGAATCGTGCGCTCGGTTGGTCCCGGCGTCACGCGCTTC
GGCATCGGCGACGAGGTCTTCTACGCCGGCTCCGTTGACCGCCAGGGCAGCAACGCCCAGTTCCACGCAGTCGATGAGCG
GATCATCGCCCGCAAGCCGCGCTCGCTGAGCTTCGCCGAAGCCGCAGCCCTGCCGCTGACGACACTCACAGCATGGGAAA
TGCTCTTCGACCGGTTTTCCATCCCGCGCGACCGCGTGCATCACGATACGTTGCTGATTGTCGGCGGCGCAGGCGGCGTC
GGCTCGATGGCGATCCAGCTTGCCTGCCAGTTGACGGGACTCGTCGTGGTCGCGACGGCCTCACGGCCGGAAACCATCAA
CTGGTGCTCATCTCTCGGCGCGCATCACGTAATCAATCACCACCATCCGCTGGCGCACCAGCTCGAGACATGCGAAGTGA
GCGCGCCAAGCTACATATTCTGCACCAACCACGTCGAACGGCACTGGCGCGAATTGTGCCATGTGCTTGCCCCGGAAGGG
CGGATTGGGCTCATCGAATCGACGGGGCCGCTTGATATGAACGAAATCTTCAACAAGTCGGCCTCGGTGCACACCGAATA
CATGTTCGCGCGCTCGCTGCATCAGACAACGCAGATGATCGAACAGCATCACATCCTGCAATCGGTGAGCCGGCTCGTCG
ACCAAGGTGTCCTCCGCACGACGATGACCGAGAATTACGGCCCGATCACGGCCGCCAATCTACGCCGTGCCCACGCGGCG
GTCGAAAGCGGAACCACACGCGGGAAGATCGTGCTCGAGGGATTCTGA

Upstream 100 bases:

>100_bases
GGGTCGCGGCAACATCCTGGCTCGCCGCTGAGGGGCCTGGATTGTTGCGGATTTCCTGAAACGGGCACGGATCTTCCGTC
CCCAAAGATGAGGCCAACTC

Downstream 100 bases:

>100_bases
GTGCGGGTGATTCTCGCCAGCACCTCGGTCACCCGGCAGTCGATGCTGAAGGCGGCCGGTGTGCTTGCGGATACCGAGTC
ATCGGGGGTCGATGAAGCGC

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKAVAFTHSLPVTADEALIDIEAPDPVLRTHDVLVEVRAVSVNPVDTKIRRRNEPLGEPRILGFDAAGIVRSVGPGVTRF
GIGDEVFYAGSVDRQGSNAQFHAVDERIIARKPRSLSFAEAAALPLTTLTAWEMLFDRFSIPRDRVHHDTLLIVGGAGGV
GSMAIQLACQLTGLVVVATASRPETINWCSSLGAHHVINHHHPLAHQLETCEVSAPSYIFCTNHVERHWRELCHVLAPEG
RIGLIESTGPLDMNEIFNKSASVHTEYMFARSLHQTTQMIEQHHILQSVSRLVDQGVLRTTMTENYGPITAANLRRAHAA
VESGTTRGKIVLEGF

Sequences:

>Translated_335_residues
MKAVAFTHSLPVTADEALIDIEAPDPVLRTHDVLVEVRAVSVNPVDTKIRRRNEPLGEPRILGFDAAGIVRSVGPGVTRF
GIGDEVFYAGSVDRQGSNAQFHAVDERIIARKPRSLSFAEAAALPLTTLTAWEMLFDRFSIPRDRVHHDTLLIVGGAGGV
GSMAIQLACQLTGLVVVATASRPETINWCSSLGAHHVINHHHPLAHQLETCEVSAPSYIFCTNHVERHWRELCHVLAPEG
RIGLIESTGPLDMNEIFNKSASVHTEYMFARSLHQTTQMIEQHHILQSVSRLVDQGVLRTTMTENYGPITAANLRRAHAA
VESGTTRGKIVLEGF
>Mature_335_residues
MKAVAFTHSLPVTADEALIDIEAPDPVLRTHDVLVEVRAVSVNPVDTKIRRRNEPLGEPRILGFDAAGIVRSVGPGVTRF
GIGDEVFYAGSVDRQGSNAQFHAVDERIIARKPRSLSFAEAAALPLTTLTAWEMLFDRFSIPRDRVHHDTLLIVGGAGGV
GSMAIQLACQLTGLVVVATASRPETINWCSSLGAHHVINHHHPLAHQLETCEVSAPSYIFCTNHVERHWRELCHVLAPEG
RIGLIESTGPLDMNEIFNKSASVHTEYMFARSLHQTTQMIEQHHILQSVSRLVDQGVLRTTMTENYGPITAANLRRAHAA
VESGTTRGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=341, Percent_Identity=26.6862170087977, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI194239676, Length=184, Percent_Identity=32.6086956521739, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI194239674, Length=184, Percent_Identity=32.6086956521739, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI13236495, Length=184, Percent_Identity=32.6086956521739, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI22538446, Length=330, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI22538444, Length=330, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI24308257, Length=160, Percent_Identity=29.375, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790485, Length=321, Percent_Identity=28.0373831775701, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=237, Percent_Identity=31.6455696202532, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=178, Percent_Identity=36.5168539325843, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324195, Length=255, Percent_Identity=27.843137254902, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36710; Mature: 36710

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVAFTHSLPVTADEALIDIEAPDPVLRTHDVLVEVRAVSVNPVDTKIRRRNEPLGEPR
CCCEEEECCCCCCCCCEEEEECCCCCHHHHHHEEEEEEEEECCCHHHHHHHCCCCCCCCE
ILGFDAAGIVRSVGPGVTRFGIGDEVFYAGSVDRQGSNAQFHAVDERIIARKPRSLSFAE
EEEECHHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCCEEEHHHHHHHHCCCCCCCHHH
AAALPLTTLTAWEMLFDRFSIPRDRVHHDTLLIVGGAGGVGSMAIQLACQLTGLVVVATA
HHHCCHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEEC
SRPETINWCSSLGAHHVINHHHPLAHQLETCEVSAPSYIFCTNHVERHWRELCHVLAPEG
CCCCHHHHHHHCCHHHHHCCCCCHHHHHHHEECCCCCEEEECHHHHHHHHHHHHHHCCCC
RIGLIESTGPLDMNEIFNKSASVHTEYMFARSLHQTTQMIEQHHILQSVSRLVDQGVLRT
CEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMTENYGPITAANLRRAHAAVESGTTRGKIVLEGF
HHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVAFTHSLPVTADEALIDIEAPDPVLRTHDVLVEVRAVSVNPVDTKIRRRNEPLGEPR
CCCEEEECCCCCCCCCEEEEECCCCCHHHHHHEEEEEEEEECCCHHHHHHHCCCCCCCCE
ILGFDAAGIVRSVGPGVTRFGIGDEVFYAGSVDRQGSNAQFHAVDERIIARKPRSLSFAE
EEEECHHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCCEEEHHHHHHHHCCCCCCCHHH
AAALPLTTLTAWEMLFDRFSIPRDRVHHDTLLIVGGAGGVGSMAIQLACQLTGLVVVATA
HHHCCHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEEC
SRPETINWCSSLGAHHVINHHHPLAHQLETCEVSAPSYIFCTNHVERHWRELCHVLAPEG
CCCCHHHHHHHCCHHHHHCCCCCHHHHHHHEECCCCCEEEECHHHHHHHHHHHHHHCCCC
RIGLIESTGPLDMNEIFNKSASVHTEYMFARSLHQTTQMIEQHHILQSVSRLVDQGVLRT
CEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMTENYGPITAANLRRAHAAVESGTTRGKIVLEGF
HHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]