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The map label for this gene is pepE [H]

Identifier: 148259235

GI number: 148259235

Start: 248503

End: 250272

Strand: Reverse

Name: pepE [H]

Synonym: Acry_0215

Alternate gene names: 148259235

Gene position: 250272-248503 (Counterclockwise)

Preceding gene: 148259237

Following gene: 148259232

Centisome position: 7.38

GC content: 69.77

Gene sequence:

>1770_bases
ATGATGAAAACGCAATTCGACTCCCTGAGAAATGCGCTTCACGATCAGGGGTTGGATGGCTTCATCCAGCCCCGGAATGA
CGAGTTTCTCGGCGAATACGTGCCCGAATCGGCGTCCCGTCTTGCCTGGCTCACCGGTTTCACCGGCAGCGCCGGCCTTG
CCATCGTGCTCGCCGACCGCGCCGCCGTCTTCTCCGATGGCCGCTACACGCTGCAACTCGTCGAACAGACCGACCCGGCG
ACCTGGGAACGGCGTCACATCGTCGAGACCCCGCCGGTCGAATGGCTGAAATCGGCCGCGCCCGGCGCGCGGATCGGCTA
CGACCCCTGGCTAATGACAGCCAACGCCGTCGCCACCTATGCCGATGCCGGGTTCACCATGGTCCCGGTGGACAACCCGA
TCGACCAGCTCTGGGCCGACCGCCCAGCGCCGCCGGCCTCGCCGGCCCTTGCGCATCCGCCGGAATTTGCCGGGGAATCC
GCCGAATCCAAGCGCTCCCGCATCGCCGAAGCCATCGCGCGGGACGGAGCGGACGCGGTGATGCTGACCGATCCGCACGC
CGTTGCCTGGCTGTTCAACCTGCGCGGAGCGGACCTGCCGCATACGCCGATCGTGCTCTGCTTCGCCCTGCTCCGGCGCG
ACGGTTCGGCAATCATCTTCATTGACCCGGCGCGGGTTCCGCCGGCAACGCGCGCGCATCTCGGCGCCGGCGTCGAGATC
GTCCCCCGCGCGGCGATGGAACGGAGCCTCGCCACGCTGCGCGGCAAGCGGGTCCTCCTCGATCCGGCAACGGCGCCGAT
CCGCTTCAGCCAGTTGCTGGGGGATGCCGGGGCGATCACCGTCTCGGGCGGCGATCCCTGCGTGTTGCCGCGCGCGATCA
AGAACCCCACCGAGCAGGAAGGCGCTCGCGCCGCGCACCGGCGCGACGGCGTGGCACTGTGCCGCTTCCTCGCCTGGTTC
GCCGAAGCTTCGCCCGCGGGCGGCCAGACCGAGCGAAGCGCCGCGGCGCAGTTGTTCGCCTTCCGCAGCACCGCTCCCGA
GTTCCATGGCGAAAGCTTCCCTGCCATTTCCGGCGCAGGCGAGCACGGCGCCATCATCCATTACAGCGTCACCGCCGCCT
CGGACCGCCCGATCCGCCACGACGAGGTCTACCTGATCGACAGCGGCGGCCAATACCCCGACGGCACGACGGATGTGACC
CGCACGCTCTGGACCGGGCCGGGCGAACCGCCGCCCACGTTGCGCGACCGCTTCACCCGCGTGCTCGCGGGCCATATCGC
CCTGGCACGCGCGCGCTTCCCGCAAGGCACGTCCGGCCCGCAGCTCGACGCTCTCGCCCGCGCGCCGCTCTGGGACGCCG
GCCTCGATTTCGATCACGGCACCGGCCACGGCGTCGGCTCCTATCTCTCGGTGCATGAGGGGCCGGCGAGCTTTCACCGG
CTGGCGAAGCCGATCCCGCTCGCGCCGGGCATGATCCTGTCCGACGAACCCGGCTATTACGAACCCGGCGGCTACGGAAT
CCGGCTGGAAAACCTGCTGCTGGTCGTCCCGTCGCCGGTCGGGGCGGCAAAGCCCTTCCTCGAATTCGAGCCGCTCACCC
TCGCCCCGTTCGACCGCCGGCTGATCGACCCTACCCTGCTCGGTCCCGCCGCCCGCGCCTGGCTCGACGCCTACCACGCC
CGCGTGCTGACAATGATCGGCCCACATCTGGACGGAGCGACGCGCACCTGGCTCGAAGCCGCTTGCGCGCCGCTACAGGA
GGTCAACTGA

Upstream 100 bases:

>100_bases
TCGTCTTTTCGCAGTGCAACATAATCCCGCAACAAAGGTTTGGGGAGCGAGACATTTCTCTGTCAGACATGCAAAAAACG
GATGGGTTTTTGGTTAAGAT

Downstream 100 bases:

>100_bases
CCGACGCCCTCAGCGCCGCCCCGGCGGCCAGCGGAGCGATCGGCAGGAACAGCGCAAGCAGTCCGCCGAGCATCGCGAAT
TCGGCGAAGGGCGACTGCGC

Product: peptidase M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MMKTQFDSLRNALHDQGLDGFIQPRNDEFLGEYVPESASRLAWLTGFTGSAGLAIVLADRAAVFSDGRYTLQLVEQTDPA
TWERRHIVETPPVEWLKSAAPGARIGYDPWLMTANAVATYADAGFTMVPVDNPIDQLWADRPAPPASPALAHPPEFAGES
AESKRSRIAEAIARDGADAVMLTDPHAVAWLFNLRGADLPHTPIVLCFALLRRDGSAIIFIDPARVPPATRAHLGAGVEI
VPRAAMERSLATLRGKRVLLDPATAPIRFSQLLGDAGAITVSGGDPCVLPRAIKNPTEQEGARAAHRRDGVALCRFLAWF
AEASPAGGQTERSAAAQLFAFRSTAPEFHGESFPAISGAGEHGAIIHYSVTAASDRPIRHDEVYLIDSGGQYPDGTTDVT
RTLWTGPGEPPPTLRDRFTRVLAGHIALARARFPQGTSGPQLDALARAPLWDAGLDFDHGTGHGVGSYLSVHEGPASFHR
LAKPIPLAPGMILSDEPGYYEPGGYGIRLENLLLVVPSPVGAAKPFLEFEPLTLAPFDRRLIDPTLLGPAARAWLDAYHA
RVLTMIGPHLDGATRTWLEAACAPLQEVN

Sequences:

>Translated_589_residues
MMKTQFDSLRNALHDQGLDGFIQPRNDEFLGEYVPESASRLAWLTGFTGSAGLAIVLADRAAVFSDGRYTLQLVEQTDPA
TWERRHIVETPPVEWLKSAAPGARIGYDPWLMTANAVATYADAGFTMVPVDNPIDQLWADRPAPPASPALAHPPEFAGES
AESKRSRIAEAIARDGADAVMLTDPHAVAWLFNLRGADLPHTPIVLCFALLRRDGSAIIFIDPARVPPATRAHLGAGVEI
VPRAAMERSLATLRGKRVLLDPATAPIRFSQLLGDAGAITVSGGDPCVLPRAIKNPTEQEGARAAHRRDGVALCRFLAWF
AEASPAGGQTERSAAAQLFAFRSTAPEFHGESFPAISGAGEHGAIIHYSVTAASDRPIRHDEVYLIDSGGQYPDGTTDVT
RTLWTGPGEPPPTLRDRFTRVLAGHIALARARFPQGTSGPQLDALARAPLWDAGLDFDHGTGHGVGSYLSVHEGPASFHR
LAKPIPLAPGMILSDEPGYYEPGGYGIRLENLLLVVPSPVGAAKPFLEFEPLTLAPFDRRLIDPTLLGPAARAWLDAYHA
RVLTMIGPHLDGATRTWLEAACAPLQEVN
>Mature_589_residues
MMKTQFDSLRNALHDQGLDGFIQPRNDEFLGEYVPESASRLAWLTGFTGSAGLAIVLADRAAVFSDGRYTLQLVEQTDPA
TWERRHIVETPPVEWLKSAAPGARIGYDPWLMTANAVATYADAGFTMVPVDNPIDQLWADRPAPPASPALAHPPEFAGES
AESKRSRIAEAIARDGADAVMLTDPHAVAWLFNLRGADLPHTPIVLCFALLRRDGSAIIFIDPARVPPATRAHLGAGVEI
VPRAAMERSLATLRGKRVLLDPATAPIRFSQLLGDAGAITVSGGDPCVLPRAIKNPTEQEGARAAHRRDGVALCRFLAWF
AEASPAGGQTERSAAAQLFAFRSTAPEFHGESFPAISGAGEHGAIIHYSVTAASDRPIRHDEVYLIDSGGQYPDGTTDVT
RTLWTGPGEPPPTLRDRFTRVLAGHIALARARFPQGTSGPQLDALARAPLWDAGLDFDHGTGHGVGSYLSVHEGPASFHR
LAKPIPLAPGMILSDEPGYYEPGGYGIRLENLLLVVPSPVGAAKPFLEFEPLTLAPFDRRLIDPTLLGPAARAWLDAYHA
RVLTMIGPHLDGATRTWLEAACAPLQEVN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=618, Percent_Identity=38.0258899676375, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI93141226, Length=601, Percent_Identity=35.9400998336107, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI264681565, Length=618, Percent_Identity=36.084142394822, Blast_Score=347, Evalue=2e-95,
Organism=Escherichia coli, GI1788728, Length=242, Percent_Identity=34.7107438016529, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=594, Percent_Identity=34.3434343434343, Blast_Score=324, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25149105, Length=593, Percent_Identity=28.6677908937605, Blast_Score=264, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6322999, Length=645, Percent_Identity=31.3178294573643, Blast_Score=287, Evalue=4e-78,
Organism=Drosophila melanogaster, GI17137632, Length=600, Percent_Identity=33.6666666666667, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI161078230, Length=594, Percent_Identity=31.1447811447811, Blast_Score=266, Evalue=4e-71,
Organism=Drosophila melanogaster, GI21357287, Length=594, Percent_Identity=31.1447811447811, Blast_Score=266, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 63228; Mature: 63228

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTQFDSLRNALHDQGLDGFIQPRNDEFLGEYVPESASRLAWLTGFTGSAGLAIVLADR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHEEEEECCCCCCCEEEEEECC
AAVFSDGRYTLQLVEQTDPATWERRHIVETPPVEWLKSAAPGARIGYDPWLMTANAVATY
HHEECCCCEEEEEEECCCCCCHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHHH
ADAGFTMVPVDNPIDQLWADRPAPPASPALAHPPEFAGESAESKRSRIAEAIARDGADAV
CCCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEE
MLTDPHAVAWLFNLRGADLPHTPIVLCFALLRRDGSAIIFIDPARVPPATRAHLGAGVEI
EEECCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCHH
VPRAAMERSLATLRGKRVLLDPATAPIRFSQLLGDAGAITVSGGDPCVLPRAIKNPTEQE
HHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCEEEECCCCCEECCHHHCCCCHHH
GARAAHRRDGVALCRFLAWFAEASPAGGQTERSAAAQLFAFRSTAPEFHGESFPAISGAG
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
EHGAIIHYSVTAASDRPIRHDEVYLIDSGGQYPDGTTDVTRTLWTGPGEPPPTLRDRFTR
CCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHH
VLAGHIALARARFPQGTSGPQLDALARAPLWDAGLDFDHGTGHGVGSYLSVHEGPASFHR
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHH
LAKPIPLAPGMILSDEPGYYEPGGYGIRLENLLLVVPSPVGAAKPFLEFEPLTLAPFDRR
HCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCHH
LIDPTLLGPAARAWLDAYHARVLTMIGPHLDGATRTWLEAACAPLQEVN
HCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHCC
>Mature Secondary Structure
MMKTQFDSLRNALHDQGLDGFIQPRNDEFLGEYVPESASRLAWLTGFTGSAGLAIVLADR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHEEEEECCCCCCCEEEEEECC
AAVFSDGRYTLQLVEQTDPATWERRHIVETPPVEWLKSAAPGARIGYDPWLMTANAVATY
HHEECCCCEEEEEEECCCCCCHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHHH
ADAGFTMVPVDNPIDQLWADRPAPPASPALAHPPEFAGESAESKRSRIAEAIARDGADAV
CCCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEE
MLTDPHAVAWLFNLRGADLPHTPIVLCFALLRRDGSAIIFIDPARVPPATRAHLGAGVEI
EEECCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCHH
VPRAAMERSLATLRGKRVLLDPATAPIRFSQLLGDAGAITVSGGDPCVLPRAIKNPTEQE
HHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCEEEECCCCCEECCHHHCCCCHHH
GARAAHRRDGVALCRFLAWFAEASPAGGQTERSAAAQLFAFRSTAPEFHGESFPAISGAG
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
EHGAIIHYSVTAASDRPIRHDEVYLIDSGGQYPDGTTDVTRTLWTGPGEPPPTLRDRFTR
CCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHH
VLAGHIALARARFPQGTSGPQLDALARAPLWDAGLDFDHGTGHGVGSYLSVHEGPASFHR
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHH
LAKPIPLAPGMILSDEPGYYEPGGYGIRLENLLLVVPSPVGAAKPFLEFEPLTLAPFDRR
HCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCHH
LIDPTLLGPAARAWLDAYHARVLTMIGPHLDGATRTWLEAACAPLQEVN
HCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]