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The map label for this gene is paaX [H]

Identifier: 148259115

GI number: 148259115

Start: 104863

End: 105732

Strand: Reverse

Name: paaX [H]

Synonym: Acry_0094

Alternate gene names: 148259115

Gene position: 105732-104863 (Counterclockwise)

Preceding gene: 148259116

Following gene: 148259113

Centisome position: 3.12

GC content: 64.71

Gene sequence:

>870_bases
ATGAATCATCATGTAGCCGCTCTTGTGGCCCGATTGCATGAGCAACCCTCCCATACCGGATCGCTTATCGTAACGCTGTT
CGGGGATGCTCTGCTACCACGCGGCAGCGCCATTGCTCTCGCTACCATACTCGACCTGTTCGAGTCCCTTGGCATTGGCC
CGGGTGTAATACGTACCGCTATCTCGAGGCTTGCCGCTGATGGCTGGCTGGTGGCGAGCCGCCGTGGCCGTTCGAGTTAC
TACCGGATCGGCCCGTCACGCCGCGGTGAGTTCATCCGCGCCGCGCGACATATCTACGGTCGGCCTCGTGGCACAGCAGC
TCGGAGCCTGATCATCGCCCTCCCCGAGCCAGGACCGGGCCGGGAACCTGCACGCGAGCGGTTCAACCGACTCGGCTTTG
CCTCATGGCAAGGCATACTGCTCGCTCCGGACCGGCCGTTGCCACGCTCGCTCGAAGCTGGGAGCATCGTTCTTCGAGCA
ACCGGCGGCCCGGAATCACTGCGCCGACTGGCGGCGCGGGCCTGGCGACTGGATGCCTTGTGCGATCACTACAAGGGATT
TCTTGCCATTTTCGGCGGGCTTACGGCCGACGCCCCGGCTTTCGATCCGCGCGATGCGCTGCTGGCCCGGCTGCTGCTGA
TCCATGACTACCGGCGGATTGTGCTGCGGGACCCGCGTCTGCCGGCTACTTTCCTACCGGAAGAGTGGGCCGGCGACGGG
GCGCGCCGACTCTGTGCCCAACTCTACGAGGCGCTACTCGATGCATCGGAGCTCTGGCTGAGCCATAACGGCGCGACCGA
GACAGGCGCGTTACCGACGGCAGATTCAACTCTGCGCCATCGTTTCGCGGACCTGCGCGGGCACGTCTGA

Upstream 100 bases:

>100_bases
TTGGTCGGCAACAATCGGGGGAGCAGGTCGTCTTGGCCATTGTCACGGTTCGGTTAACGCAGCACTGGCGAAGCTGGGCG
GATTGAGGTCTTATCCGACC

Downstream 100 bases:

>100_bases
TCCCACCCGCCCGCTTGGCCTGGCCCCACCGAGGAACAAGCCGACAGCACGGGCAATCCGGGCATCGATTTCGGCACGGC
TACGGGCCTTTCCGATGCCC

Product: PaaX family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNHHVAALVARLHEQPSHTGSLIVTLFGDALLPRGSAIALATILDLFESLGIGPGVIRTAISRLAADGWLVASRRGRSSY
YRIGPSRRGEFIRAARHIYGRPRGTAARSLIIALPEPGPGREPARERFNRLGFASWQGILLAPDRPLPRSLEAGSIVLRA
TGGPESLRRLAARAWRLDALCDHYKGFLAIFGGLTADAPAFDPRDALLARLLLIHDYRRIVLRDPRLPATFLPEEWAGDG
ARRLCAQLYEALLDASELWLSHNGATETGALPTADSTLRHRFADLRGHV

Sequences:

>Translated_289_residues
MNHHVAALVARLHEQPSHTGSLIVTLFGDALLPRGSAIALATILDLFESLGIGPGVIRTAISRLAADGWLVASRRGRSSY
YRIGPSRRGEFIRAARHIYGRPRGTAARSLIIALPEPGPGREPARERFNRLGFASWQGILLAPDRPLPRSLEAGSIVLRA
TGGPESLRRLAARAWRLDALCDHYKGFLAIFGGLTADAPAFDPRDALLARLLLIHDYRRIVLRDPRLPATFLPEEWAGDG
ARRLCAQLYEALLDASELWLSHNGATETGALPTADSTLRHRFADLRGHV
>Mature_289_residues
MNHHVAALVARLHEQPSHTGSLIVTLFGDALLPRGSAIALATILDLFESLGIGPGVIRTAISRLAADGWLVASRRGRSSY
YRIGPSRRGEFIRAARHIYGRPRGTAARSLIIALPEPGPGREPARERFNRLGFASWQGILLAPDRPLPRSLEAGSIVLRA
TGGPESLRRLAARAWRLDALCDHYKGFLAIFGGLTADAPAFDPRDALLARLLLIHDYRRIVLRDPRLPATFLPEEWAGDG
ARRLCAQLYEALLDASELWLSHNGATETGALPTADSTLRHRFADLRGHV

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=294, Percent_Identity=33.6734693877551, Blast_Score=118, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 31611; Mature: 31611

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHHVAALVARLHEQPSHTGSLIVTLFGDALLPRGSAIALATILDLFESLGIGPGVIRTA
CCHHHHHHHHHHHHCCCCCCCEEHEEHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ISRLAADGWLVASRRGRSSYYRIGPSRRGEFIRAARHIYGRPRGTAARSLIIALPEPGPG
HHHHHCCCEEEECCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
REPARERFNRLGFASWQGILLAPDRPLPRSLEAGSIVLRATGGPESLRRLAARAWRLDAL
CCHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
CDHYKGFLAIFGGLTADAPAFDPRDALLARLLLIHDYRRIVLRDPRLPATFLPEEWAGDG
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHCCCH
ARRLCAQLYEALLDASELWLSHNGATETGALPTADSTLRHRFADLRGHV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHHVAALVARLHEQPSHTGSLIVTLFGDALLPRGSAIALATILDLFESLGIGPGVIRTA
CCHHHHHHHHHHHHCCCCCCCEEHEEHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ISRLAADGWLVASRRGRSSYYRIGPSRRGEFIRAARHIYGRPRGTAARSLIIALPEPGPG
HHHHHCCCEEEECCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
REPARERFNRLGFASWQGILLAPDRPLPRSLEAGSIVLRATGGPESLRRLAARAWRLDAL
CCHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
CDHYKGFLAIFGGLTADAPAFDPRDALLARLLLIHDYRRIVLRDPRLPATFLPEEWAGDG
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHCCCH
ARRLCAQLYEALLDASELWLSHNGATETGALPTADSTLRHRFADLRGHV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]