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The map label for this gene is lpxB [H]

Identifier: 148259061

GI number: 148259061

Start: 38471

End: 39610

Strand: Reverse

Name: lpxB [H]

Synonym: Acry_0040

Alternate gene names: 148259061

Gene position: 39610-38471 (Counterclockwise)

Preceding gene: 148259062

Following gene: 148259054

Centisome position: 1.17

GC content: 70.09

Gene sequence:

>1140_bases
ATGACGCTGGTTTATGTCGTCGCCGGTGAAGCAAGCGGCGACGTGCTGGGTGCGCGGCTGATCGCGGCCATGCGCGCGCG
GGCCGGCGGCATCGAAGTTGCCGGCATCGGCGGCGCGAGGATGGCCGAACAGGGTGTTGCCTCGCTGTTCCCGATGCAGG
AACTGGCGCTCATGGGCCTCGCGGAAGTCCTGCCCAAGCTCTTCCGGCTGCGCCGCCGGCTCGAGCAGACGGAAGCGGAC
ATTGCCGCGAGGCGGCCGGACATCGTCGTGACCATCGACAGTCCGGGCTTCACGCTCCGCCTGCTCCGGCGAATCGCCCC
GCTCGGACTCCGCCGCGTGCATTACGTCGCCCCCCAGGTCTGGGCCTGGCGACAGGGGCGGGTAAAGCACTTCCCCGGCC
TGTGGGACCGGCTGCTCTGCCTCCTGCCCTTCGAGCCGGATTTCTTTGCACCGCATGGGCTGAACCCGGTCTTTGTCGGC
CATCCGGTGCTGGAATCGGGTGCCGATGCCGGCGATCCTGCGCGCTTCCGTGCCCGGTTCGGCCTGGCGGAGTCAGCGCG
TTCCCTGATCCTGATGCCTGGCAGCCGCCGCACGGAAACGGCCCGGCTGATGCCGGTTTTCGGCGCGACGGTGGAACGCC
TCCGCCCACGATTTCCGGATCTCGTGCCGGTGCTGGCCGCGGCGCCGGCACTCGCCGGCGAGTTGCAGGCGCAGGCGGCC
GCCTGGCCGCGCCCGCCGCTGATCGTCACCAATGTGGCCGAGCGGTATGACGCCTTCGCCGGCGCCGAAGCCGCGCTGAC
GAAATCCGGCACCTCGACGCTGGAACTGGCTCTGGCCGGCGTGCCGATGGCGGTCACCTACCGGGTCAATCCGATCAGCG
CGATGCTGGCCCGGCGGCTGATCAAGGTGCCGCACGTCGCCATGATCAACCTGCTCGCCGGGCAAGAACTGGTGCCGGAA
CTGTTGCAGGATGCCTGCACGCCGGAGCGCCTCTCCGCCGAAATCGCCTCGCTGCTCGGCGACCCTGAGCGGGCTGCAGC
GCAACGGGCCGGCTTCAGCGCTGCCCTATCCACGCTCGCCATCGCGGGATCGGCGTCTCCCAGCGAAGCCGCGGCAACGG
CCGTGCTCGACCTGCTCTGA

Upstream 100 bases:

>100_bases
TCGATCCCGCCCGCCTCGCCGCCACGCGCGACGACCCAGCCGTCCGCAACCGGACCGACTGGCCGGACGATCCGGCGCCG
GCCCGAATCGTCCGCCTGAC

Downstream 100 bases:

>100_bases
TCGGCGTTCCGGCCTGCACACGCAAAAAGCCGCAGCGCCAGCCTATAGGCGCAAGGAACAAGCGATTCTCCGCGCCCCAC
AACACCAAAAGGCCCGAAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTLVYVVAGEASGDVLGARLIAAMRARAGGIEVAGIGGARMAEQGVASLFPMQELALMGLAEVLPKLFRLRRRLEQTEAD
IAARRPDIVVTIDSPGFTLRLLRRIAPLGLRRVHYVAPQVWAWRQGRVKHFPGLWDRLLCLLPFEPDFFAPHGLNPVFVG
HPVLESGADAGDPARFRARFGLAESARSLILMPGSRRTETARLMPVFGATVERLRPRFPDLVPVLAAAPALAGELQAQAA
AWPRPPLIVTNVAERYDAFAGAEAALTKSGTSTLELALAGVPMAVTYRVNPISAMLARRLIKVPHVAMINLLAGQELVPE
LLQDACTPERLSAEIASLLGDPERAAAQRAGFSAALSTLAIAGSASPSEAAATAVLDLL

Sequences:

>Translated_379_residues
MTLVYVVAGEASGDVLGARLIAAMRARAGGIEVAGIGGARMAEQGVASLFPMQELALMGLAEVLPKLFRLRRRLEQTEAD
IAARRPDIVVTIDSPGFTLRLLRRIAPLGLRRVHYVAPQVWAWRQGRVKHFPGLWDRLLCLLPFEPDFFAPHGLNPVFVG
HPVLESGADAGDPARFRARFGLAESARSLILMPGSRRTETARLMPVFGATVERLRPRFPDLVPVLAAAPALAGELQAQAA
AWPRPPLIVTNVAERYDAFAGAEAALTKSGTSTLELALAGVPMAVTYRVNPISAMLARRLIKVPHVAMINLLAGQELVPE
LLQDACTPERLSAEIASLLGDPERAAAQRAGFSAALSTLAIAGSASPSEAAATAVLDLL
>Mature_378_residues
TLVYVVAGEASGDVLGARLIAAMRARAGGIEVAGIGGARMAEQGVASLFPMQELALMGLAEVLPKLFRLRRRLEQTEADI
AARRPDIVVTIDSPGFTLRLLRRIAPLGLRRVHYVAPQVWAWRQGRVKHFPGLWDRLLCLLPFEPDFFAPHGLNPVFVGH
PVLESGADAGDPARFRARFGLAESARSLILMPGSRRTETARLMPVFGATVERLRPRFPDLVPVLAAAPALAGELQAQAAA
WPRPPLIVTNVAERYDAFAGAEAALTKSGTSTLELALAGVPMAVTYRVNPISAMLARRLIKVPHVAMINLLAGQELVPEL
LQDACTPERLSAEIASLLGDPERAAAQRAGFSAALSTLAIAGSASPSEAAATAVLDLL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=384, Percent_Identity=38.0208333333333, Blast_Score=215, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 40393; Mature: 40261

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVYVVAGEASGDVLGARLIAAMRARAGGIEVAGIGGARMAEQGVASLFPMQELALMGL
CEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHH
AEVLPKLFRLRRRLEQTEADIAARRPDIVVTIDSPGFTLRLLRRIAPLGLRRVHYVAPQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHH
WAWRQGRVKHFPGLWDRLLCLLPFEPDFFAPHGLNPVFVGHPVLESGADAGDPARFRARF
HHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHCCCCCCCCHHHHHHH
GLAESARSLILMPGSRRTETARLMPVFGATVERLRPRFPDLVPVLAAAPALAGELQAQAA
CHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
AWPRPPLIVTNVAERYDAFAGAEAALTKSGTSTLELALAGVPMAVTYRVNPISAMLARRL
CCCCCCEEEHHHHHHHHHHCCCHHHHHCCCCCCEEHEECCCCEEEEEEECHHHHHHHHHH
IKVPHVAMINLLAGQELVPELLQDACTPERLSAEIASLLGDPERAAAQRAGFSAALSTLA
HHCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHH
IAGSASPSEAAATAVLDLL
HCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TLVYVVAGEASGDVLGARLIAAMRARAGGIEVAGIGGARMAEQGVASLFPMQELALMGL
EEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHH
AEVLPKLFRLRRRLEQTEADIAARRPDIVVTIDSPGFTLRLLRRIAPLGLRRVHYVAPQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHH
WAWRQGRVKHFPGLWDRLLCLLPFEPDFFAPHGLNPVFVGHPVLESGADAGDPARFRARF
HHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHCCCCCCCCHHHHHHH
GLAESARSLILMPGSRRTETARLMPVFGATVERLRPRFPDLVPVLAAAPALAGELQAQAA
CHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
AWPRPPLIVTNVAERYDAFAGAEAALTKSGTSTLELALAGVPMAVTYRVNPISAMLARRL
CCCCCCEEEHHHHHHHHHHCCCHHHHHCCCCCCEEHEECCCCEEEEEEECHHHHHHHHHH
IKVPHVAMINLLAGQELVPELLQDACTPERLSAEIASLLGDPERAAAQRAGFSAALSTLA
HHCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHH
IAGSASPSEAAATAVLDLL
HCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA