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The map label for this gene is pth [H]

Identifier: 148243439

GI number: 148243439

Start: 2037200

End: 2037805

Strand: Direct

Name: pth [H]

Synonym: SynRCC307_2340

Alternate gene names: 148243439

Gene position: 2037200-2037805 (Clockwise)

Preceding gene: 148243438

Following gene: 148243440

Centisome position: 91.56

GC content: 63.86

Gene sequence:

>606_bases
ATGACGCCAATGATGCTGCTGGTCGGCCTGGGTAATCCCGGATCCAAATACGACGGCACGCGACACAACGTGGGCTTCAT
GGCGCTCGATCGTCTCGCCGCCGCAGGGAGCGGCAGCTTTCGTGCCAACACCAAATTGCATGGCGATCTTGCTGATATCG
GCCAAGGCGACCGCCGCCTGCGGCTACTCAAACCTCAGACCTATATGAACGACAGCGGCCGGGCGATCCGGGCCAGCCTG
GATTGGTTTGGTTGGACGCCCGAGCAACTGCTGGTGATCGTTGATGACATGGATCTTCCCCTCGGCCGGCTGCGGCTGAG
GCTCAACGGTGGAGCCGGAGGGCACAACGGCCTGCGGAGCACGATTGCCCACCTGGGGGGCGAGGCCTTTGCCCGCCTGC
GGATTGGCATCGGCGCTCCCGGCACCAGCAGCGAAGAGCGCAAGGAAGGCACGGTGGGGCACGTGCTTGGCAACTTCCAC
CCTGCGGAACGTCCCTTGTTGGATGAGGTGCTGCAGGAGGTGGAGCACGGCATCGGCCTGATTCAACGCCAAGGCTTTGA
GCGCGCTGGCAACCGGATCAACAGCTTTCGGCCAGACGCCGCCTGA

Upstream 100 bases:

>100_bases
TCTGAATTTGAGCAGGAGTTCCGCAAGGCCGTTGATTCGGTCGAACTCCCCGCAGGTCAAACTGACGCCACTTCCAGCCA
GGACGCCACCACGCCTGCCG

Downstream 100 bases:

>100_bases
CCATGGCACGCCTGCCCAGCACCACAGCCCACTTGCGGGTTCTGCAGCAGAGCTTCAGCGAGCAGATGGTGGAAGGAGAA
GTGGCCGCTGGTGGTTTTCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTPMMLLVGLGNPGSKYDGTRHNVGFMALDRLAAAGSGSFRANTKLHGDLADIGQGDRRLRLLKPQTYMNDSGRAIRASL
DWFGWTPEQLLVIVDDMDLPLGRLRLRLNGGAGGHNGLRSTIAHLGGEAFARLRIGIGAPGTSSEERKEGTVGHVLGNFH
PAERPLLDEVLQEVEHGIGLIQRQGFERAGNRINSFRPDAA

Sequences:

>Translated_201_residues
MTPMMLLVGLGNPGSKYDGTRHNVGFMALDRLAAAGSGSFRANTKLHGDLADIGQGDRRLRLLKPQTYMNDSGRAIRASL
DWFGWTPEQLLVIVDDMDLPLGRLRLRLNGGAGGHNGLRSTIAHLGGEAFARLRIGIGAPGTSSEERKEGTVGHVLGNFH
PAERPLLDEVLQEVEHGIGLIQRQGFERAGNRINSFRPDAA
>Mature_200_residues
TPMMLLVGLGNPGSKYDGTRHNVGFMALDRLAAAGSGSFRANTKLHGDLADIGQGDRRLRLLKPQTYMNDSGRAIRASLD
WFGWTPEQLLVIVDDMDLPLGRLRLRLNGGAGGHNGLRSTIAHLGGEAFARLRIGIGAPGTSSEERKEGTVGHVLGNFHP
AERPLLDEVLQEVEHGIGLIQRQGFERAGNRINSFRPDAA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=42.8571428571429, Blast_Score=117, Evalue=8e-27,
Organism=Escherichia coli, GI1787455, Length=195, Percent_Identity=40, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321983, Length=168, Percent_Identity=34.5238095238095, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21739; Mature: 21608

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPMMLLVGLGNPGSKYDGTRHNVGFMALDRLAAAGSGSFRANTKLHGDLADIGQGDRRL
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEECCCHHHCCCCCCEE
RLLKPQTYMNDSGRAIRASLDWFGWTPEQLLVIVDDMDLPLGRLRLRLNGGAGGHNGLRS
EEECCCCEECCCCCEEEEECCCCCCCHHHEEEEEECCCCCHHHEEEEECCCCCCCHHHHH
TIAHLGGEAFARLRIGIGAPGTSSEERKEGTVGHVLGNFHPAERPLLDEVLQEVEHGIGL
HHHHHCCHHEEEEEEECCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IQRQGFERAGNRINSFRPDAA
HHHCCHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
TPMMLLVGLGNPGSKYDGTRHNVGFMALDRLAAAGSGSFRANTKLHGDLADIGQGDRRL
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEECCCHHHCCCCCCEE
RLLKPQTYMNDSGRAIRASLDWFGWTPEQLLVIVDDMDLPLGRLRLRLNGGAGGHNGLRS
EEECCCCEECCCCCEEEEECCCCCCCHHHEEEEEECCCCCHHHEEEEECCCCCCCHHHHH
TIAHLGGEAFARLRIGIGAPGTSSEERKEGTVGHVLGNFHPAERPLLDEVLQEVEHGIGL
HHHHHCCHHEEEEEEECCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IQRQGFERAGNRINSFRPDAA
HHHCCHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA