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The map label for this gene is hisB

Identifier: 148243389

GI number: 148243389

Start: 1988718

End: 1989329

Strand: Direct

Name: hisB

Synonym: SynRCC307_2290

Alternate gene names: 148243389

Gene position: 1988718-1989329 (Clockwise)

Preceding gene: 148243388

Following gene: 148243390

Centisome position: 89.38

GC content: 61.93

Gene sequence:

>612_bases
ATGGGCCGGCAAGGAAACATCCATCGCGTCACCGGAGAAACCGAGGTCCGTGTGGCCATCGGCCTGGATGGCAGTGGCCA
ATGCGAGGTGAGCACCGGCGTGCCCTTCCTCGATCACATGCTCCATCAACTGGCCAGCCATGGGCTGTTTGATCTGACGA
TCAGCGCCACTGGTGACACCCATATCGACGATCACCACACTAATGAGGATGTGGGCATTGCCTTGGGCCAAGCGCTCGGG
CAAGCCCTTGCCGATCGCCGCGGCATCCACCGCTTTGGCCACTTTGTGGCCCCCCTCGATGAGGCCTTGGTGCAGGTGGC
GCTCGACTGCTCCGGCCGGCCGCACGTGAGTTATTCCCTGGCCATCCCAGCGCAAAAAATTGGCAGCTACGACACCGAGC
TGGTCAAAGAGTTCTTTGTTGCCGTGGCCAACAACGCTGGGCTGACCCTGCACATCCGCCAACTCGATGGGGTGAATTCA
CACCACATCGTTGAAGCCTGCTTCAAGGCCTTCGCCCGCGCGTTGCGCATGGCCACCGAAATCGATCCGCGCCGCGCCAG
CGCAATTCCCAGCAGCAAAGGGGTGCTCGAGCAGGCCGGCACCACAGGTTGA

Upstream 100 bases:

>100_bases
CGGGCAAACCATCTATGTGGATGCCGGCTACTGCGTCAACGGCATGTGAGCCTGGACCGATCGCCCAGGCCTGTCAGCAT
GGGGTGAATGGCGATCGGGC

Downstream 100 bases:

>100_bases
GGCGTGCGCTGGTTCATCAAGCGGGAAACCTTTCGGCGGCCAGCTGCTGAGCTCAAACAGGCGATCGCAGCCCACAGGCG
CTGGGTGGCGGACTGCCGCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MGRQGNIHRVTGETEVRVAIGLDGSGQCEVSTGVPFLDHMLHQLASHGLFDLTISATGDTHIDDHHTNEDVGIALGQALG
QALADRRGIHRFGHFVAPLDEALVQVALDCSGRPHVSYSLAIPAQKIGSYDTELVKEFFVAVANNAGLTLHIRQLDGVNS
HHIVEACFKAFARALRMATEIDPRRASAIPSSKGVLEQAGTTG

Sequences:

>Translated_203_residues
MGRQGNIHRVTGETEVRVAIGLDGSGQCEVSTGVPFLDHMLHQLASHGLFDLTISATGDTHIDDHHTNEDVGIALGQALG
QALADRRGIHRFGHFVAPLDEALVQVALDCSGRPHVSYSLAIPAQKIGSYDTELVKEFFVAVANNAGLTLHIRQLDGVNS
HHIVEACFKAFARALRMATEIDPRRASAIPSSKGVLEQAGTTG
>Mature_202_residues
GRQGNIHRVTGETEVRVAIGLDGSGQCEVSTGVPFLDHMLHQLASHGLFDLTISATGDTHIDDHHTNEDVGIALGQALGQ
ALADRRGIHRFGHFVAPLDEALVQVALDCSGRPHVSYSLAIPAQKIGSYDTELVKEFFVAVANNAGLTLHIRQLDGVNSH
HIVEACFKAFARALRMATEIDPRRASAIPSSKGVLEQAGTTG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=48.4536082474227, Blast_Score=186, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=214, Percent_Identity=41.1214953271028, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SYNR3 (A5GWD4)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001228546.1
- ProteinModelPortal:   A5GWD4
- SMR:   A5GWD4
- STRING:   A5GWD4
- GeneID:   5157319
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_2290
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21674; Mature: 21543

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRQGNIHRVTGETEVRVAIGLDGSGQCEVSTGVPFLDHMLHQLASHGLFDLTISATGDT
CCCCCCEEEECCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCC
HIDDHHTNEDVGIALGQALGQALADRRGIHRFGHFVAPLDEALVQVALDCSGRPHVSYSL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEE
AIPAQKIGSYDTELVKEFFVAVANNAGLTLHIRQLDGVNSHHIVEACFKAFARALRMATE
ECCHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IDPRRASAIPSSKGVLEQAGTTG
CCCHHHHCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
GRQGNIHRVTGETEVRVAIGLDGSGQCEVSTGVPFLDHMLHQLASHGLFDLTISATGDT
CCCCCEEEECCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCC
HIDDHHTNEDVGIALGQALGQALADRRGIHRFGHFVAPLDEALVQVALDCSGRPHVSYSL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEE
AIPAQKIGSYDTELVKEFFVAVANNAGLTLHIRQLDGVNSHHIVEACFKAFARALRMATE
ECCHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IDPRRASAIPSSKGVLEQAGTTG
CCCHHHHCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA