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The map label for this gene is srrA [H]

Identifier: 148243360

GI number: 148243360

Start: 1966396

End: 1967130

Strand: Direct

Name: srrA [H]

Synonym: SynRCC307_2261

Alternate gene names: 148243360

Gene position: 1966396-1967130 (Clockwise)

Preceding gene: 148243359

Following gene: 148243361

Centisome position: 88.38

GC content: 62.72

Gene sequence:

>735_bases
ATGGATGGCTCTCAGGAGAAGGACCACGCCGAAGAACTGCTGAATGCCCCGCCGCGGGTGTTGCTGGTGGATGACGAGCC
CGGTCTGCGCACAGCGGTGCAGGCCTACTTCGAAGATGAAGGCTTCATCGTCAGCACCGCCGCCGATGGCGAAGAGGGCT
GGGAGAAGGCTCAGAGCGAAGTGCCTGACGTTGTGCTCAGCGACGTGATGATGCCGCGGGTGGATGGCTTTGGGCTGCTC
AAGTTGCTGCGCGAAGACGAACGCCTGGGCGGAACCCCGGTGATCTTCCTCACCGCCAAGGGCATGACGGCCGACCGCAT
CGCCGGCTTTCGGGCGGGGGTGGACGACTACATCCCCAAGCCATTTGACCCCGATGAATTGGTGGCGCGGGTTCGCAACG
TCGTGCAGCGCCAGGAGCGCCTGCTCAAAGAAGCGGCCCGCTATGCCGATACCGACCTGGGCCAAATGGCCAAACAAATC
GGCGAAATTCGCACGATGCTTCAAGGCGGTGCCGGCAAGGCCGCAGGCCAAAGCGTGGAGCATTCCTTCACGCCGCGGGA
AGCCAGCGTGCTGCAGCTGGTGGCCGAAGGACTGATGAATAAGGAAATCGCCCGCCAGCTGGAGACATCGATCCGCAATG
TCGAAAAGTATGTGAGCCGTTTGTTTGCCAAGACCGGCACCGCGAGCCGCACGGAGCTGGTGCGCTACGCCCTTGAGCAC
GGCTTGGTGCACTAG

Upstream 100 bases:

>100_bases
TCGCCCAAGAGCTGGGTTTCAGCGGGCTGCTGATCGAACGTCAGCATGTCTTGCCTGGACGCCCTCGATAAAGTCCAGGC
GCTGCGTGTGATCTCTGCCC

Downstream 100 bases:

>100_bases
CTGCGGTGCAGAGCTGGCGCGAGGCCGCGCTGAACCAAGGCTGGACTTACCGCCATCGGGTGCAGCTAGCCGAAGCTGGC
CAAGCTGCCCTGGAGCTATT

Product: two-component system response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MDGSQEKDHAEELLNAPPRVLLVDDEPGLRTAVQAYFEDEGFIVSTAADGEEGWEKAQSEVPDVVLSDVMMPRVDGFGLL
KLLREDERLGGTPVIFLTAKGMTADRIAGFRAGVDDYIPKPFDPDELVARVRNVVQRQERLLKEAARYADTDLGQMAKQI
GEIRTMLQGGAGKAAGQSVEHSFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFAKTGTASRTELVRYALEH
GLVH

Sequences:

>Translated_244_residues
MDGSQEKDHAEELLNAPPRVLLVDDEPGLRTAVQAYFEDEGFIVSTAADGEEGWEKAQSEVPDVVLSDVMMPRVDGFGLL
KLLREDERLGGTPVIFLTAKGMTADRIAGFRAGVDDYIPKPFDPDELVARVRNVVQRQERLLKEAARYADTDLGQMAKQI
GEIRTMLQGGAGKAAGQSVEHSFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFAKTGTASRTELVRYALEH
GLVH
>Mature_244_residues
MDGSQEKDHAEELLNAPPRVLLVDDEPGLRTAVQAYFEDEGFIVSTAADGEEGWEKAQSEVPDVVLSDVMMPRVDGFGLL
KLLREDERLGGTPVIFLTAKGMTADRIAGFRAGVDDYIPKPFDPDELVARVRNVVQRQERLLKEAARYADTDLGQMAKQI
GEIRTMLQGGAGKAAGQSVEHSFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFAKTGTASRTELVRYALEH
GLVH

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=213, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367329, Length=182, Percent_Identity=36.8131868131868, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790860, Length=150, Percent_Identity=36, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787229, Length=121, Percent_Identity=37.1900826446281, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=38.655462184874, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788394, Length=120, Percent_Identity=36.6666666666667, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786784, Length=127, Percent_Identity=33.0708661417323, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790863, Length=124, Percent_Identity=36.2903225806452, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788550, Length=152, Percent_Identity=35.5263157894737, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790299, Length=184, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787473, Length=221, Percent_Identity=31.6742081447964, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI87082012, Length=123, Percent_Identity=32.520325203252, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788222, Length=230, Percent_Identity=30, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787375, Length=120, Percent_Identity=31.6666666666667, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=35.2941176470588, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=27.9816513761468, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788905, Length=206, Percent_Identity=27.6699029126214, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786747, Length=229, Percent_Identity=22.2707423580786, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=33.9805825242718, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790437, Length=139, Percent_Identity=28.0575539568345, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=27.5109170305677, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26909; Mature: 26909

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSQEKDHAEELLNAPPRVLLVDDEPGLRTAVQAYFEDEGFIVSTAADGEEGWEKAQSE
CCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
VPDVVLSDVMMPRVDGFGLLKLLREDERLGGTPVIFLTAKGMTADRIAGFRAGVDDYIPK
CHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCHHHCCCC
PFDPDELVARVRNVVQRQERLLKEAARYADTDLGQMAKQIGEIRTMLQGGAGKAAGQSVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCHH
HSFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFAKTGTASRTELVRYALEH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GLVH
CCCC
>Mature Secondary Structure
MDGSQEKDHAEELLNAPPRVLLVDDEPGLRTAVQAYFEDEGFIVSTAADGEEGWEKAQSE
CCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
VPDVVLSDVMMPRVDGFGLLKLLREDERLGGTPVIFLTAKGMTADRIAGFRAGVDDYIPK
CHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCHHHCCCC
PFDPDELVARVRNVVQRQERLLKEAARYADTDLGQMAKQIGEIRTMLQGGAGKAAGQSVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCHH
HSFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFAKTGTASRTELVRYALEH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GLVH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA