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The map label for this gene is nadC [H]

Identifier: 148243339

GI number: 148243339

Start: 1948829

End: 1949728

Strand: Direct

Name: nadC [H]

Synonym: SynRCC307_2240

Alternate gene names: 148243339

Gene position: 1948829-1949728 (Clockwise)

Preceding gene: 148243337

Following gene: 148243340

Centisome position: 87.59

GC content: 65.44

Gene sequence:

>900_bases
ATGGGATTGATGTGGCCAGCTCCTGCCGTGGCAATCCCCCCTCTGGCGATAACGCCAGCGCTGCAGCAGCACTTGCAGAC
CTGGCTGCAGGAAGACCTGGGACGCGGTGATCTCAGTGCCGCGGCGCTGCAGGGCTGCTGCGGCCAAGCCCACTGGATCA
GCAAGGCCGATGGTGTGTTCTGCGGAGGGCAACTGGCCGCAGCCGTGTTTGGCCTGATGGACTCCGGCGTGACAGCGCAG
GTGCTAGTGAACGATGGCGAGGCCATCAGCGCTGGCACCCGCCTGCTGGAACTAGGAGGGCCCGCAGCGGCTCTGGTGGG
AGCCGAACGCACCGCACTCAATCTGGCGATGCGGCTCTCGGGCATCGCCACAGCAACGGCAGCCCTGGCCAGCCAACTGC
AGGGCAGTGGCGTGCAGTTGGTGGATACCCGCAAAACAACCCCAGGGCTGCGGGTGCTCGAGAAATACGCCGTGCGCTGT
GGTGGCGGCATCAACCACCGCATGGGCCTCGACGATGCCGCGATGCTCAAGGAAAACCACCTGGCCTGGGCTGGTGGGGT
GGCTGCCGCCGTTGCGGCGGTCCGCGCAGCAGCCCCTTGGCCAAGCCAGGTGATCGTTGAAGCCGAAACCCTTGAGGAAG
CCAAGGCTGCTGTAGCCGCTGGCGCTGATGGGGTGTTGCTCGATGAATTCAGCCCCGATGCGCTCAAGCAACTGGTGCCC
GAGCTGCGGCACCAGGCCAAGCAGAGGGGCAAGCCCGTGGTGCTGGAAGCCAGCGGCATCCAGCCCGATCAATTGAGGCT
CTACGCCAGCAGCGGCATCGATCTGATCTCCACCAGTGCTCCGATCACCCGTAGCTCCTGGCTGGATCTGAGCATGCGGT
TCTCCGGCCAGGAGGGATGA

Upstream 100 bases:

>100_bases
TGAGGGCTAACGCCAGGAAGCCATCGAGATCACCTGGCCTCCAAACCAGACCAAACCCTGGTTGCTGTGTTGCCATGCCC
CTGCCTGATCGCGGCCCATC

Downstream 100 bases:

>100_bases
TCAGAGGCTGTGTCCACCGCTGCTGCGGTCCCTGTTCATGCTGCGCATTGCCCAAACCCTGGAGGCCCAGCTGCGCGCAG
CCATGCAGCAGGCGTTTCCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MGLMWPAPAVAIPPLAITPALQQHLQTWLQEDLGRGDLSAAALQGCCGQAHWISKADGVFCGGQLAAAVFGLMDSGVTAQ
VLVNDGEAISAGTRLLELGGPAAALVGAERTALNLAMRLSGIATATAALASQLQGSGVQLVDTRKTTPGLRVLEKYAVRC
GGGINHRMGLDDAAMLKENHLAWAGGVAAAVAAVRAAAPWPSQVIVEAETLEEAKAAVAAGADGVLLDEFSPDALKQLVP
ELRHQAKQRGKPVVLEASGIQPDQLRLYASSGIDLISTSAPITRSSWLDLSMRFSGQEG

Sequences:

>Translated_299_residues
MGLMWPAPAVAIPPLAITPALQQHLQTWLQEDLGRGDLSAAALQGCCGQAHWISKADGVFCGGQLAAAVFGLMDSGVTAQ
VLVNDGEAISAGTRLLELGGPAAALVGAERTALNLAMRLSGIATATAALASQLQGSGVQLVDTRKTTPGLRVLEKYAVRC
GGGINHRMGLDDAAMLKENHLAWAGGVAAAVAAVRAAAPWPSQVIVEAETLEEAKAAVAAGADGVLLDEFSPDALKQLVP
ELRHQAKQRGKPVVLEASGIQPDQLRLYASSGIDLISTSAPITRSSWLDLSMRFSGQEG
>Mature_298_residues
GLMWPAPAVAIPPLAITPALQQHLQTWLQEDLGRGDLSAAALQGCCGQAHWISKADGVFCGGQLAAAVFGLMDSGVTAQV
LVNDGEAISAGTRLLELGGPAAALVGAERTALNLAMRLSGIATATAALASQLQGSGVQLVDTRKTTPGLRVLEKYAVRCG
GGINHRMGLDDAAMLKENHLAWAGGVAAAVAAVRAAAPWPSQVIVEAETLEEAKAAVAAGADGVLLDEFSPDALKQLVPE
LRHQAKQRGKPVVLEASGIQPDQLRLYASSGIDLISTSAPITRSSWLDLSMRFSGQEG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=295, Percent_Identity=37.2881355932203, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1786299, Length=274, Percent_Identity=41.970802919708, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=292, Percent_Identity=34.2465753424658, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30851; Mature: 30719

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLMWPAPAVAIPPLAITPALQQHLQTWLQEDLGRGDLSAAALQGCCGQAHWISKADGVF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEE
CGGQLAAAVFGLMDSGVTAQVLVNDGEAISAGTRLLELGGPAAALVGAERTALNLAMRLS
ECHHHHHHHHHHHCCCCEEEEEECCCCEEHHCCEEEECCCCHHHHHCCHHHHHHHHHHHH
GIATATAALASQLQGSGVQLVDTRKTTPGLRVLEKYAVRCGGGINHRMGLDDAAMLKENH
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
LAWAGGVAAAVAAVRAAAPWPSQVIVEAETLEEAKAAVAAGADGVLLDEFSPDALKQLVP
CCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHH
ELRHQAKQRGKPVVLEASGIQPDQLRLYASSGIDLISTSAPITRSSWLDLSMRFSGQEG
HHHHHHHHCCCCEEEEECCCCHHHEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
GLMWPAPAVAIPPLAITPALQQHLQTWLQEDLGRGDLSAAALQGCCGQAHWISKADGVF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEE
CGGQLAAAVFGLMDSGVTAQVLVNDGEAISAGTRLLELGGPAAALVGAERTALNLAMRLS
ECHHHHHHHHHHHCCCCEEEEEECCCCEEHHCCEEEECCCCHHHHHCCHHHHHHHHHHHH
GIATATAALASQLQGSGVQLVDTRKTTPGLRVLEKYAVRCGGGINHRMGLDDAAMLKENH
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
LAWAGGVAAAVAAVRAAAPWPSQVIVEAETLEEAKAAVAAGADGVLLDEFSPDALKQLVP
CCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHH
ELRHQAKQRGKPVVLEASGIQPDQLRLYASSGIDLISTSAPITRSSWLDLSMRFSGQEG
HHHHHHHHCCCCEEEEECCCCHHHEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]