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The map label for this gene is hisD [H]

Identifier: 148243061

GI number: 148243061

Start: 1706458

End: 1707768

Strand: Direct

Name: hisD [H]

Synonym: SynRCC307_1962

Alternate gene names: 148243061

Gene position: 1706458-1707768 (Clockwise)

Preceding gene: 148243045

Following gene: 148243065

Centisome position: 76.7

GC content: 63.62

Gene sequence:

>1311_bases
GTGATTGTCTCGACAGACGCGATGATGCAGCTGCTCAACGACCCTGTCGCGGCCGTTGATCGTCTGCGGCAAATCGAAGC
GAGAACCCACTCCAGTGGCGTCGCTACAGCGCAAGCCACCGTGGATTCCGTTCTTGCGGCTGTCAAAGAGCGCGGCGATG
CAGCCCTCAAGGAGTACACCGAGCGTTTTGACGGGGTTGTGCTCGACTGCCTGCGGGTGGATCCAGCCGCGACTAAGGCG
GCCTGGCAGAGCGCTCCCCTGGCTTTGCGCGATGCCCTGCAACTGGCCCATCGGCGCATCAGCGCTTTTCACCGCGAACA
ATTACCGCAGGACATCGAGCTCAAAGGTCCCCATGGGGAACGCCTTGGCAGGCGTTGGCGCCCGGTCAACTCCGCTGGGC
TCTATGTGCCTGGTGGCCGCGCGGCTTACCCCAGCACGGTGTTGATGAATGCCATCCCCGCCCAAGTCGCGGGGGTGAAG
CAAGTGGTGATGGTCACCCCGCCAGGGCCAGACGGGCAAGTCAACCCCGCCGTGTTGGCGGCCGCCCACGTGGCTGGCGT
CGATCAGATCTACAGCGTCGGCGGCGCTCAAGCCGTGGCGGCGCTGGCCTTCGGCACCGAGTCGATCCCCGCGGTGGACG
TGATCACCGGACCTGGAAATTTGTTTGTGACCCTGGCCAAAAAAAGCGTGTATGGCCGGGTTGGCATTGATTCGCTGGCT
GGGCCCAGCGAAGTGTTGGTGATCGCCGATGACAGCGCCTCAGCCGAGCTGGTGGCGGCGGATTTGCTGGCCCAAGCAGA
GCACGACCCCCTGGCTGCAGCGATTCTGCTGACCACCAGCCCGCGCCTCGTGCAAGAGGTGCCCGAGGCGATTGCAGCGC
AACTGGAGGATCACCCCAGGCGCGAGGTAACGGAAGCCTCGATCCGCGATTGGGGCTTAATAGTGCTCTGCGAATCACTC
GAGCAAGCCGCGCAGCTCTCCGATCGCTTTGCTCCTGAACATCTGGAGTTGTTGGTGCAGGAACCAGCCGCGCTGGCTGA
ACGCATTCAGCAGGCCGGCGCGATCTTCATGGGACAGCACACCCCAGAAGCAGCTGGCGACTACCTTGCTGGGCCCAATC
ACACCCTGCCGACCTCCGGGACAGCCCGCTTTGCTGGCGCCTTGAGCGTCGAAACGTTCATGCGCCACACCAGCCTGATC
AACTTCAACCGGCAAGCGCTTGAAGCCACGGGCGCAGCGATCATGGAGTTAGCAGCCCATGAGGGATTGCATAGTCACCG
CGAGTCGGTGCGCCGCAGGCTGCAGAGCTGA

Upstream 100 bases:

>100_bases
TTACGAGCAGACTTGTTATTCGCCACAGAAGTTTCGGGGCCGCAGATCGACAAACAAAGATCCTAACTCCACAGCCTTCC
CTAGAGGTGGCTTAGCGTCA

Downstream 100 bases:

>100_bases
CTTACGGGGTCACGAGCCAATGGGCGGGCTCTTGGCCAGGGATCATCTGCAACACCAGATCGCCTGGGCGGGGCTCACCC
ACTCGTCTGCCAGCAATCCA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MIVSTDAMMQLLNDPVAAVDRLRQIEARTHSSGVATAQATVDSVLAAVKERGDAALKEYTERFDGVVLDCLRVDPAATKA
AWQSAPLALRDALQLAHRRISAFHREQLPQDIELKGPHGERLGRRWRPVNSAGLYVPGGRAAYPSTVLMNAIPAQVAGVK
QVVMVTPPGPDGQVNPAVLAAAHVAGVDQIYSVGGAQAVAALAFGTESIPAVDVITGPGNLFVTLAKKSVYGRVGIDSLA
GPSEVLVIADDSASAELVAADLLAQAEHDPLAAAILLTTSPRLVQEVPEAIAAQLEDHPRREVTEASIRDWGLIVLCESL
EQAAQLSDRFAPEHLELLVQEPAALAERIQQAGAIFMGQHTPEAAGDYLAGPNHTLPTSGTARFAGALSVETFMRHTSLI
NFNRQALEATGAAIMELAAHEGLHSHRESVRRRLQS

Sequences:

>Translated_436_residues
MIVSTDAMMQLLNDPVAAVDRLRQIEARTHSSGVATAQATVDSVLAAVKERGDAALKEYTERFDGVVLDCLRVDPAATKA
AWQSAPLALRDALQLAHRRISAFHREQLPQDIELKGPHGERLGRRWRPVNSAGLYVPGGRAAYPSTVLMNAIPAQVAGVK
QVVMVTPPGPDGQVNPAVLAAAHVAGVDQIYSVGGAQAVAALAFGTESIPAVDVITGPGNLFVTLAKKSVYGRVGIDSLA
GPSEVLVIADDSASAELVAADLLAQAEHDPLAAAILLTTSPRLVQEVPEAIAAQLEDHPRREVTEASIRDWGLIVLCESL
EQAAQLSDRFAPEHLELLVQEPAALAERIQQAGAIFMGQHTPEAAGDYLAGPNHTLPTSGTARFAGALSVETFMRHTSLI
NFNRQALEATGAAIMELAAHEGLHSHRESVRRRLQS
>Mature_436_residues
MIVSTDAMMQLLNDPVAAVDRLRQIEARTHSSGVATAQATVDSVLAAVKERGDAALKEYTERFDGVVLDCLRVDPAATKA
AWQSAPLALRDALQLAHRRISAFHREQLPQDIELKGPHGERLGRRWRPVNSAGLYVPGGRAAYPSTVLMNAIPAQVAGVK
QVVMVTPPGPDGQVNPAVLAAAHVAGVDQIYSVGGAQAVAALAFGTESIPAVDVITGPGNLFVTLAKKSVYGRVGIDSLA
GPSEVLVIADDSASAELVAADLLAQAEHDPLAAAILLTTSPRLVQEVPEAIAAQLEDHPRREVTEASIRDWGLIVLCESL
EQAAQLSDRFAPEHLELLVQEPAALAERIQQAGAIFMGQHTPEAAGDYLAGPNHTLPTSGTARFAGALSVETFMRHTSLI
NFNRQALEATGAAIMELAAHEGLHSHRESVRRRLQS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=417, Percent_Identity=40.5275779376499, Blast_Score=295, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=402, Percent_Identity=41.044776119403, Blast_Score=296, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46227; Mature: 46227

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSTDAMMQLLNDPVAAVDRLRQIEARTHSSGVATAQATVDSVLAAVKERGDAALKEYT
CEECHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHH
ERFDGVVLDCLRVDPAATKAAWQSAPLALRDALQLAHRRISAFHREQLPQDIELKGPHGE
HHHCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHH
RLGRRWRPVNSAGLYVPGGRAAYPSTVLMNAIPAQVAGVKQVVMVTPPGPDGQVNPAVLA
HHHHHCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
AAHVAGVDQIYSVGGAQAVAALAFGTESIPAVDVITGPGNLFVTLAKKSVYGRVGIDSLA
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECHHHCCCCCCCCCC
GPSEVLVIADDSASAELVAADLLAQAEHDPLAAAILLTTSPRLVQEVPEAIAAQLEDHPR
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCH
REVTEASIRDWGLIVLCESLEQAAQLSDRFAPEHLELLVQEPAALAERIQQAGAIFMGQH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCCEEECCC
TPEAAGDYLAGPNHTLPTSGTARFAGALSVETFMRHTSLINFNRQALEATGAAIMELAAH
CCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EGLHSHRESVRRRLQS
CCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVSTDAMMQLLNDPVAAVDRLRQIEARTHSSGVATAQATVDSVLAAVKERGDAALKEYT
CEECHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHH
ERFDGVVLDCLRVDPAATKAAWQSAPLALRDALQLAHRRISAFHREQLPQDIELKGPHGE
HHHCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHH
RLGRRWRPVNSAGLYVPGGRAAYPSTVLMNAIPAQVAGVKQVVMVTPPGPDGQVNPAVLA
HHHHHCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
AAHVAGVDQIYSVGGAQAVAALAFGTESIPAVDVITGPGNLFVTLAKKSVYGRVGIDSLA
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECHHHCCCCCCCCCC
GPSEVLVIADDSASAELVAADLLAQAEHDPLAAAILLTTSPRLVQEVPEAIAAQLEDHPR
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCH
REVTEASIRDWGLIVLCESLEQAAQLSDRFAPEHLELLVQEPAALAERIQQAGAIFMGQH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCCEEECCC
TPEAAGDYLAGPNHTLPTSGTARFAGALSVETFMRHTSLINFNRQALEATGAAIMELAAH
CCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EGLHSHRESVRRRLQS
CCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]