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The map label for this gene is bioF [H]

Identifier: 148243023

GI number: 148243023

Start: 1668580

End: 1669707

Strand: Direct

Name: bioF [H]

Synonym: SynRCC307_1924

Alternate gene names: 148243023

Gene position: 1668580-1669707 (Clockwise)

Preceding gene: 148243019

Following gene: 148243024

Centisome position: 75.0

GC content: 68.79

Gene sequence:

>1128_bases
ATGGGTGACCAGCCACCACAGCGAGTTCGGCGGCTGCGAACGTTCCAGATGGACCAGCCCGGTCAGCTGCGCAGCAGCGC
TGATCAGGCCCTGTTGGATCTCGCCAGCAACGACACCTTGGGGTTGCTGGGGCACCCAGATCTCAATGCCGCAGCCCAAG
CGGCCATTGCATCCAGTGGTGTTGGCAGCGGTGCCTCCCGGCTGATCAGCGGCAGCCGGCCGGAGCACGCAGAGCTTGAG
CACGGCTTGGCCCAGTGGCTGGGACGCAGCCGCGTGCTGCTATTCCCCAGCGGGTTTCAGGCCAACATCGCCGCCCTGCA
GCTACTGGCTGATCGCCACATGGTGGTGCTGGCCGACCGGCGCATCCACCACTCGTTGCTGGTGGGCGTGCGGGCCTGCG
GCGCCAAGCTCGAGCGCTTTGGCCACAACAACCTCGAAGACCTCGAGCGGCGCCTGCACCAGCGCCAGGGCAGCCGCTGC
GTGGTGCTCAGCGAAAGCCTGTTTTCGATGGAAGGCAGCAGCCCCGATGTGGGCGCACTAGCAGCGCTCTGCCAGCGCCA
CGGCGCCCCCTTGCTGCTCGATGAAGCCCATGCCCTCGGTGTTTTGGGCCCCGGTGGGCGCGGGCTGGGCCATGGGCTCG
ATGGGGTGAGCCTGCTGTGCGGCACCTTTGGCAAGGCCTTTGCCAGCGGCGGCGCGTTTTTAGCCTGCGGCGAATCGCTG
GGGGAAGAGCTGCTGCAAACCAGCGGCGCCTTTCGCTACACCACAGCCCTAGCGCCACCCCTCGCCGCGGCGGCCGCCGC
GGCCTTGCAGTTGATTGCCTCGCCTGAAGGTGATCAGCGGCGCCAGCAACTGCGCCAACACAGCGAGCTTTGGCGCGATT
CGCTCAGCCGCGCGGGTTGGCCCCGCCCAGCCGGCGTTGGCCCGATCGTGGCGCTGAAGCTGGGGGATGACAGCCGGGCC
CTCGAGGCCGCAGCCGCCCTGGAAGAGGAGGGCCTGCTGGTGGTCGCCATCCGCCCGCCCACCGTGCCCGAAGGTGAGGC
GATGCTGCGCTTCAGCCTGCGGCCGCAGCTTCCCGAAGACGCGCTGAGCCGGGTGCTGGCAACGCTGGAGCCCTTCAAAC
GGTCGTGA

Upstream 100 bases:

>100_bases
GGGAACGGAAACAGCGCCGCCGGATCCAGTCCGCTGTTCGAGCTCAGAGCGACTCCACCATCCTGGGAGTCTGCAGTGGC
GGCATTCATGGCTAGATCTT

Downstream 100 bases:

>100_bases
TCAAAGATGGACTCCACACCGCAGTGATGCGCCGTTGGGTTCTTCTTGGCAGCTGATCGGCATGCACGGCTGGGGCAGCG
ACCAGCGCAACTGGGACGCT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MGDQPPQRVRRLRTFQMDQPGQLRSSADQALLDLASNDTLGLLGHPDLNAAAQAAIASSGVGSGASRLISGSRPEHAELE
HGLAQWLGRSRVLLFPSGFQANIAALQLLADRHMVVLADRRIHHSLLVGVRACGAKLERFGHNNLEDLERRLHQRQGSRC
VVLSESLFSMEGSSPDVGALAALCQRHGAPLLLDEAHALGVLGPGGRGLGHGLDGVSLLCGTFGKAFASGGAFLACGESL
GEELLQTSGAFRYTTALAPPLAAAAAAALQLIASPEGDQRRQQLRQHSELWRDSLSRAGWPRPAGVGPIVALKLGDDSRA
LEAAAALEEEGLLVVAIRPPTVPEGEAMLRFSLRPQLPEDALSRVLATLEPFKRS

Sequences:

>Translated_375_residues
MGDQPPQRVRRLRTFQMDQPGQLRSSADQALLDLASNDTLGLLGHPDLNAAAQAAIASSGVGSGASRLISGSRPEHAELE
HGLAQWLGRSRVLLFPSGFQANIAALQLLADRHMVVLADRRIHHSLLVGVRACGAKLERFGHNNLEDLERRLHQRQGSRC
VVLSESLFSMEGSSPDVGALAALCQRHGAPLLLDEAHALGVLGPGGRGLGHGLDGVSLLCGTFGKAFASGGAFLACGESL
GEELLQTSGAFRYTTALAPPLAAAAAAALQLIASPEGDQRRQQLRQHSELWRDSLSRAGWPRPAGVGPIVALKLGDDSRA
LEAAAALEEEGLLVVAIRPPTVPEGEAMLRFSLRPQLPEDALSRVLATLEPFKRS
>Mature_374_residues
GDQPPQRVRRLRTFQMDQPGQLRSSADQALLDLASNDTLGLLGHPDLNAAAQAAIASSGVGSGASRLISGSRPEHAELEH
GLAQWLGRSRVLLFPSGFQANIAALQLLADRHMVVLADRRIHHSLLVGVRACGAKLERFGHNNLEDLERRLHQRQGSRCV
VLSESLFSMEGSSPDVGALAALCQRHGAPLLLDEAHALGVLGPGGRGLGHGLDGVSLLCGTFGKAFASGGAFLACGESLG
EELLQTSGAFRYTTALAPPLAAAAAAALQLIASPEGDQRRQQLRQHSELWRDSLSRAGWPRPAGVGPIVALKLGDDSRAL
EAAAALEEEGLLVVAIRPPTVPEGEAMLRFSLRPQLPEDALSRVLATLEPFKRS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=342, Percent_Identity=30.4093567251462, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=30.2593659942363, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=29.3150684931507, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=30.4225352112676, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=30.4225352112676, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=30.4225352112676, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4502025, Length=343, Percent_Identity=31.4868804664723, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI40316939, Length=343, Percent_Identity=31.4868804664723, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=27.6243093922652, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI5454084, Length=244, Percent_Identity=28.6885245901639, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=38.0813953488372, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1790046, Length=352, Percent_Identity=32.1022727272727, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI32566772, Length=387, Percent_Identity=27.6485788113695, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=334, Percent_Identity=28.4431137724551, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=319, Percent_Identity=26.9592476489028, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560912, Length=319, Percent_Identity=26.9592476489028, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71982617, Length=261, Percent_Identity=26.8199233716475, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=261, Percent_Identity=26.8199233716475, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=360, Percent_Identity=30.2777777777778, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320267, Length=363, Percent_Identity=26.4462809917355, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=286, Percent_Identity=23.4265734265734, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24662918, Length=355, Percent_Identity=28.4507042253521, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI17137420, Length=329, Percent_Identity=32.5227963525836, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI17136286, Length=360, Percent_Identity=28.6111111111111, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653280, Length=253, Percent_Identity=25.6916996047431, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24653276, Length=253, Percent_Identity=25.6916996047431, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24653278, Length=253, Percent_Identity=25.6916996047431, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 39692; Mature: 39561

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDQPPQRVRRLRTFQMDQPGQLRSSADQALLDLASNDTLGLLGHPDLNAAAQAAIASSG
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCC
VGSGASRLISGSRPEHAELEHGLAQWLGRSRVLLFPSGFQANIAALQLLADRHMVVLADR
CCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECH
RIHHSLLVGVRACGAKLERFGHNNLEDLERRLHQRQGSRCVVLSESLFSMEGSSPDVGAL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCHHHH
AALCQRHGAPLLLDEAHALGVLGPGGRGLGHGLDGVSLLCGTFGKAFASGGAFLACGESL
HHHHHHCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHH
GEELLQTSGAFRYTTALAPPLAAAAAAALQLIASPEGDQRRQQLRQHSELWRDSLSRAGW
HHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PRPAGVGPIVALKLGDDSRALEAAAALEEEGLLVVAIRPPTVPEGEAMLRFSLRPQLPED
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEECCCCCCHH
ALSRVLATLEPFKRS
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
GDQPPQRVRRLRTFQMDQPGQLRSSADQALLDLASNDTLGLLGHPDLNAAAQAAIASSG
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCC
VGSGASRLISGSRPEHAELEHGLAQWLGRSRVLLFPSGFQANIAALQLLADRHMVVLADR
CCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECH
RIHHSLLVGVRACGAKLERFGHNNLEDLERRLHQRQGSRCVVLSESLFSMEGSSPDVGAL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCHHHH
AALCQRHGAPLLLDEAHALGVLGPGGRGLGHGLDGVSLLCGTFGKAFASGGAFLACGESL
HHHHHHCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHH
GEELLQTSGAFRYTTALAPPLAAAAAAALQLIASPEGDQRRQQLRQHSELWRDSLSRAGW
HHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PRPAGVGPIVALKLGDDSRALEAAAALEEEGLLVVAIRPPTVPEGEAMLRFSLRPQLPED
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEECCCCCCHH
ALSRVLATLEPFKRS
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA