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The map label for this gene is purD [H]

Identifier: 148242921

GI number: 148242921

Start: 1585114

End: 1586409

Strand: Direct

Name: purD [H]

Synonym: SynRCC307_1822

Alternate gene names: 148242921

Gene position: 1585114-1586409 (Clockwise)

Preceding gene: 148242911

Following gene: 148242922

Centisome position: 71.24

GC content: 63.5

Gene sequence:

>1296_bases
ATGGCCGTGGAGCGCATTTTGGTCGTGGGCAATGGGGGGCGAGAGAACGCCCTGGCCTGGGCAATGGCTCGCAGCCCGCA
GCAGCCGCAGGTGTGGATTAGCCCCGGCAATGGCGCCAGCGCCGCCATCCCTGGCTGCACCGTGCTGAACCATGCCGCCA
GTGATGCCGCAGCGCTAGCGAGCTGTTGCCAAACCCTGGGCATCGACTTGGCCGTGATTGGCCCAGAAGCACCCCTGGCC
GCTGGCCTCGCCGATCAACTCAGAAGTGCTGGGATCGCTGTGTTTGGTCCTGGAGCCGATGGCGCCCAACTGGAAGCCAG
CAAGGAATGGGCCAAAACCTTGATGCAACAAGCCGGTGTTCCCACCGCAGGCTTCTGGGTCGCCACCAGCGCTGAGCAGG
GCAAAGCCATCGCCGAAGAGCAGGGCAAAGCCTTTGTAGTCAAAGCCGATGGGCTAGCTGCCGGCAAAGGCGTCACCGTG
GCCTGCAGCTTGGAAGAAACACTTACCGCCATTGAGGAGTGCTTTTCCGGCCGCTTTGGTGATGCCGGCCAGCGGGTTGT
ACTGGAGGAGTGCCTCCAGGGCCCAGAGGTCTCGGTCTTTGCCCTCTGTGATGGGGAGCGGCTGGTGCTACTGCCGCCGG
CGCAGGATCACAAACGCATCGGCGAAGGCGACACGGGGCCGAACACCGGGGGCATGGGTGCCTACGCGCCAGCGCCACTA
CTTGATGAAGCGGGCTTGCAGCAGGTGCAAACGAGCATCCTGGAGCCGGTGGTGCAGGCCCTGCGCCAACGGGGAATCGA
CTATCGCGGGGTGATCTATGCGGGGCTGATGCTCACCAGCTCTGGGCCGCAGGTGATCGAATTCAACTGCCGCTTTGGTG
ATCCGGAATGCCAAACGCTGATGCCCCTTCTTCAGGGCGACCTGGCCGAAGTGCTGTTGGCCTGCGCCAACGGCCATCTT
GATCAAGCACCTGCGCTCACCATCGCGCCCCTCTGCAGCGCCTGTGTGGTGGCTGCTGCGGCTGGTTATCCAGGCACACC
GCAACTGGGTGACCCCATCTGCGATGAAGGTCCAGGCCTCGATTGCAGCCAGGACTCCAGCCAGCTTTTTGCTGCAGGTG
TGAAGGCCGATGCCAATGGCGAGCTGCAAACCAGCGGTGGCCGGGTGCTGGCGGCCGTCGCCCAAGGCCATGATTTTGAT
GAGGCCTTTGCCAGGGCCTACAAGCGATTGGCTCAAGTGAAGTTTGCAGGCATGCAGCTGCGCCGCGACATCGGCCATCA
GGTGCGGCGTCTTTAG

Upstream 100 bases:

>100_bases
CACCTGGAGGCAAAGGCGCTGGTGCTAACGCCACCAAAAAGGCCGAGAGCATTGCCGCGTTAGGAGGGAAGAGCACAACA
ACGCTGGAGGTGCGGCAAGT

Downstream 100 bases:

>100_bases
GCTGAGAGCAACCAAACCGGTCACCTGAGCAACTCCGCCGCTACTGAAACGCTGCCGTGGTGGCGCCGGCTGCCAGCCCT
CACCAGCGGCTGGTGGGCGG

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MAVERILVVGNGGRENALAWAMARSPQQPQVWISPGNGASAAIPGCTVLNHAASDAAALASCCQTLGIDLAVIGPEAPLA
AGLADQLRSAGIAVFGPGADGAQLEASKEWAKTLMQQAGVPTAGFWVATSAEQGKAIAEEQGKAFVVKADGLAAGKGVTV
ACSLEETLTAIEECFSGRFGDAGQRVVLEECLQGPEVSVFALCDGERLVLLPPAQDHKRIGEGDTGPNTGGMGAYAPAPL
LDEAGLQQVQTSILEPVVQALRQRGIDYRGVIYAGLMLTSSGPQVIEFNCRFGDPECQTLMPLLQGDLAEVLLACANGHL
DQAPALTIAPLCSACVVAAAAGYPGTPQLGDPICDEGPGLDCSQDSSQLFAAGVKADANGELQTSGGRVLAAVAQGHDFD
EAFARAYKRLAQVKFAGMQLRRDIGHQVRRL

Sequences:

>Translated_431_residues
MAVERILVVGNGGRENALAWAMARSPQQPQVWISPGNGASAAIPGCTVLNHAASDAAALASCCQTLGIDLAVIGPEAPLA
AGLADQLRSAGIAVFGPGADGAQLEASKEWAKTLMQQAGVPTAGFWVATSAEQGKAIAEEQGKAFVVKADGLAAGKGVTV
ACSLEETLTAIEECFSGRFGDAGQRVVLEECLQGPEVSVFALCDGERLVLLPPAQDHKRIGEGDTGPNTGGMGAYAPAPL
LDEAGLQQVQTSILEPVVQALRQRGIDYRGVIYAGLMLTSSGPQVIEFNCRFGDPECQTLMPLLQGDLAEVLLACANGHL
DQAPALTIAPLCSACVVAAAAGYPGTPQLGDPICDEGPGLDCSQDSSQLFAAGVKADANGELQTSGGRVLAAVAQGHDFD
EAFARAYKRLAQVKFAGMQLRRDIGHQVRRL
>Mature_430_residues
AVERILVVGNGGRENALAWAMARSPQQPQVWISPGNGASAAIPGCTVLNHAASDAAALASCCQTLGIDLAVIGPEAPLAA
GLADQLRSAGIAVFGPGADGAQLEASKEWAKTLMQQAGVPTAGFWVATSAEQGKAIAEEQGKAFVVKADGLAAGKGVTVA
CSLEETLTAIEECFSGRFGDAGQRVVLEECLQGPEVSVFALCDGERLVLLPPAQDHKRIGEGDTGPNTGGMGAYAPAPLL
DEAGLQQVQTSILEPVVQALRQRGIDYRGVIYAGLMLTSSGPQVIEFNCRFGDPECQTLMPLLQGDLAEVLLACANGHLD
QAPALTIAPLCSACVVAAAAGYPGTPQLGDPICDEGPGLDCSQDSSQLFAAGVKADANGELQTSGGRVLAAVAQGHDFDE
AFARAYKRLAQVKFAGMQLRRDIGHQVRRL

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=426, Percent_Identity=44.8356807511737, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI209869995, Length=426, Percent_Identity=44.8356807511737, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI209869993, Length=426, Percent_Identity=44.8356807511737, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI28416899, Length=426, Percent_Identity=44.8356807511737, Blast_Score=342, Evalue=5e-94,
Organism=Escherichia coli, GI1790438, Length=424, Percent_Identity=43.6320754716981, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17567511, Length=431, Percent_Identity=40.1392111368909, Blast_Score=288, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6321203, Length=441, Percent_Identity=39.4557823129252, Blast_Score=303, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24582400, Length=436, Percent_Identity=45.4128440366972, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI62471619, Length=436, Percent_Identity=45.4128440366972, Blast_Score=331, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 44439; Mature: 44308

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERILVVGNGGRENALAWAMARSPQQPQVWISPGNGASAAIPGCTVLNHAASDAAALA
CCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
SCCQTLGIDLAVIGPEAPLAAGLADQLRSAGIAVFGPGADGAQLEASKEWAKTLMQQAGV
HHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCC
PTAGFWVATSAEQGKAIAEEQGKAFVVKADGLAAGKGVTVACSLEETLTAIEECFSGRFG
CCCCEEEEECCHHCCHHHHCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
DAGQRVVLEECLQGPEVSVFALCDGERLVLLPPAQDHKRIGEGDTGPNTGGMGAYAPAPL
CCCCHHHHHHHHCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCC
LDEAGLQQVQTSILEPVVQALRQRGIDYRGVIYAGLMLTSSGPQVIEFNCRFGDPECQTL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCCEEEEEECCCCCHHHHH
MPLLQGDLAEVLLACANGHLDQAPALTIAPLCSACVVAAAAGYPGTPQLGDPICDEGPGL
HHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DCSQDSSQLFAAGVKADANGELQTSGGRVLAAVAQGHDFDEAFARAYKRLAQVKFAGMQL
CCCCCCHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
RRDIGHQVRRL
HHHHHHHHHCC
>Mature Secondary Structure 
AVERILVVGNGGRENALAWAMARSPQQPQVWISPGNGASAAIPGCTVLNHAASDAAALA
CCEEEEEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
SCCQTLGIDLAVIGPEAPLAAGLADQLRSAGIAVFGPGADGAQLEASKEWAKTLMQQAGV
HHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCC
PTAGFWVATSAEQGKAIAEEQGKAFVVKADGLAAGKGVTVACSLEETLTAIEECFSGRFG
CCCCEEEEECCHHCCHHHHCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
DAGQRVVLEECLQGPEVSVFALCDGERLVLLPPAQDHKRIGEGDTGPNTGGMGAYAPAPL
CCCCHHHHHHHHCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCC
LDEAGLQQVQTSILEPVVQALRQRGIDYRGVIYAGLMLTSSGPQVIEFNCRFGDPECQTL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCCEEEEEECCCCCHHHHH
MPLLQGDLAEVLLACANGHLDQAPALTIAPLCSACVVAAAAGYPGTPQLGDPICDEGPGL
HHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DCSQDSSQLFAAGVKADANGELQTSGGRVLAAVAQGHDFDEAFARAYKRLAQVKFAGMQL
CCCCCCHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
RRDIGHQVRRL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]