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The map label for this gene is mprA [H]

Identifier: 148242843

GI number: 148242843

Start: 1526463

End: 1527170

Strand: Direct

Name: mprA [H]

Synonym: SynRCC307_1744

Alternate gene names: 148242843

Gene position: 1526463-1527170 (Clockwise)

Preceding gene: 148242842

Following gene: 148242844

Centisome position: 68.61

GC content: 64.83

Gene sequence:

>708_bases
ATGAAGCCCACCTTGCTGCTCATCGGTGAGCGCGCCTTGGAATTGCGCGAGCGGCTGGAGGCTTCCGGCTACGACACCGT
GGGCTGGAGCGGCAGCGATGCCGTCCAATCGATTGGAGCCGGGTTGATCCCGCAAGATCGGGTCAAGGCAGTGCTGATCA
CCAGCGATGAGCTGGCGGTGGTGCCATTGCTGCAAAAGAGCTGCGGCGCTGGCGATCGGGTGCCGCTGCTGGTGGAGGCG
ATGGCCGATGACCTGGCCGCCCGCAGCCAGTGCCTCAAGCTCGGCGCCAACGACTTTTGGGTGCAAGACGGCCCGCCCAG
CGATCTGCTGCAGCGCCTCAGGCTCCAACTTGCGCTGGAGCCACGGCCCCACAGCCTGTTTGATGCACCCGCCGGCGACA
CCAAGCAGGCAACGTTGAAACTGCTGGATCTACGCCTGGAGCCGCGGCAACGGCGCGCCTGGCGGGGCGAGCGCGAATTG
CAGCTCACCGAACGGGAATACTCGCTACTGCTGCTGTTGCTGGAGCACCAAGGCGGCAGCGTCAGCCGCCAAACGATCCT
GGAAGAGGTGTGGGGCCAGAGCGATGAGGAGGCCAACGCCAACGTGATTGAGGTGTATGTGCGCTATTTGCGCCGCAAGC
TGGAGGAAAACGGCGAACGGCGCTTGATTCACACCGTGCGCGGCGTGGGCTACACGCTCAGGAGCTGA

Upstream 100 bases:

>100_bases
TTGTGCGCCTGGCCGACCACGAATACTTCCGCGTATTGGGCGAGAAGCTGGGCTGGGGCCTGCCCCATGTGGCCAAGCCG
GGCACACTTCCTTTGGCCTC

Downstream 100 bases:

>100_bases
TTCAGGCGATGTTCGCTCCCCTGTTGCCTCTGCTGCTGGCGATCACGCCTCAGTATCTGCCGATCACCGCCAAGTGGTGC
CTGCCCCAGGGCTGCATTGG

Product: two-component sytem response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKPTLLLIGERALELRERLEASGYDTVGWSGSDAVQSIGAGLIPQDRVKAVLITSDELAVVPLLQKSCGAGDRVPLLVEA
MADDLAARSQCLKLGANDFWVQDGPPSDLLQRLRLQLALEPRPHSLFDAPAGDTKQATLKLLDLRLEPRQRRAWRGEREL
QLTEREYSLLLLLLEHQGGSVSRQTILEEVWGQSDEEANANVIEVYVRYLRRKLEENGERRLIHTVRGVGYTLRS

Sequences:

>Translated_235_residues
MKPTLLLIGERALELRERLEASGYDTVGWSGSDAVQSIGAGLIPQDRVKAVLITSDELAVVPLLQKSCGAGDRVPLLVEA
MADDLAARSQCLKLGANDFWVQDGPPSDLLQRLRLQLALEPRPHSLFDAPAGDTKQATLKLLDLRLEPRQRRAWRGEREL
QLTEREYSLLLLLLEHQGGSVSRQTILEEVWGQSDEEANANVIEVYVRYLRRKLEENGERRLIHTVRGVGYTLRS
>Mature_235_residues
MKPTLLLIGERALELRERLEASGYDTVGWSGSDAVQSIGAGLIPQDRVKAVLITSDELAVVPLLQKSCGAGDRVPLLVEA
MADDLAARSQCLKLGANDFWVQDGPPSDLLQRLRLQLALEPRPHSLFDAPAGDTKQATLKLLDLRLEPRQRRAWRGEREL
QLTEREYSLLLLLLEHQGGSVSRQTILEEVWGQSDEEANANVIEVYVRYLRRKLEENGERRLIHTVRGVGYTLRS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=164, Percent_Identity=31.0975609756098, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082012, Length=161, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789402, Length=163, Percent_Identity=33.7423312883436, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786599, Length=162, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786911, Length=159, Percent_Identity=30.8176100628931, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790552, Length=160, Percent_Identity=31.875, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26340; Mature: 26340

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTLLLIGERALELRERLEASGYDTVGWSGSDAVQSIGAGLIPQDRVKAVLITSDELAV
CCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHCCEEEEECCCEEE
VPLLQKSCGAGDRVPLLVEAMADDLAARSQCLKLGANDFWVQDGPPSDLLQRLRLQLALE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCC
PRPHSLFDAPAGDTKQATLKLLDLRLEPRQRRAWRGERELQLTEREYSLLLLLLEHQGGS
CCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCEEEHHHHHHEEEEEEECCCCC
VSRQTILEEVWGQSDEEANANVIEVYVRYLRRKLEENGERRLIHTVRGVGYTLRS
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKPTLLLIGERALELRERLEASGYDTVGWSGSDAVQSIGAGLIPQDRVKAVLITSDELAV
CCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHCCEEEEECCCEEE
VPLLQKSCGAGDRVPLLVEAMADDLAARSQCLKLGANDFWVQDGPPSDLLQRLRLQLALE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCC
PRPHSLFDAPAGDTKQATLKLLDLRLEPRQRRAWRGERELQLTEREYSLLLLLLEHQGGS
CCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCEEEHHHHHHEEEEEEECCCCC
VSRQTILEEVWGQSDEEANANVIEVYVRYLRRKLEENGERRLIHTVRGVGYTLRS
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA