Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 148242773

GI number: 148242773

Start: 1465898

End: 1467160

Strand: Direct

Name: dxr [H]

Synonym: SynRCC307_1674

Alternate gene names: 148242773

Gene position: 1465898-1467160 (Clockwise)

Preceding gene: 148242769

Following gene: 148242774

Centisome position: 65.89

GC content: 65.16

Gene sequence:

>1263_bases
TTGGCCAATTCGATGGGAGACTGGGTGCCCTCTAAGGCAGTGGCCGTGAAAGCTCTCAGCGTGCTGGGCTCCACCGGCTC
CATCGGAACGCAAACCCTCGAAATCGTTGAGGAGTTTCCCGAGCGCTTCCGCGTGGTGGCCCTCACCGCCGGCCGCAACT
TGGCGTTGCTGTGCAAGCAGGTGCAGCGCCATCAGCCCGAAGTGGTGGCCCTGGCCGATCCCGCCCTGCTGAGTGAGCTG
CGCGAGCGACTCCAGGCTCTGAACCTGCCGCGCTGTCCTGAACTGGTGGCCGGCAACGAGGGGCTCTGCCAGGCCGCCGC
CTGGAGCAGCGCCGATCTGGTGGTCACTGGAATCGTGGGCTGCGCGGGCCTCCTGCCCACCCTGGCGGCGATTGAAGCCG
GCAAAGATCTGGCCCTGGCCAACAAAGAAACCCTGATTGCCGCTGGGCCGGTGGTGCTGCCGGCACTGGAGCGCAGCGGC
AGTCGCCTGCTGCCGGCTGATTCCGAGCACTCGGCGATCTTCCAGTGCCTTCAGGGCACCCCCTGGGCTGATACCGCCCG
GCTCTCCACGGGTGTGCCCACACCCGGGCTGCGCCGCATCCAACTCACCGCCTCTGGCGGTGCCTTCCGCGACTGGGCTG
CCGCCGATCTAGCCAAGGCCACGGTGGCCGATGCCACCAGCCACCCCAACTGGAGCATGGGGCGCAAGATCACGGTGGAT
TCCGCCTCATTGATGAACAAGGGGCTGGAAGTGATCGAAGCCCACTACCTCTATGGCGTGGATTACGACCACATCGAAAT
CGTGATCCACCCGCAATCGATCATCCATTCGATGGTGGAGCTGGCCGATTCCTCGGTGCTGGCGCAGCTGGGCTGGCCCG
ACATGAAGCTGCCGATCCTCTATTGCCTCAGCTGGCCGGAGCGACTGGAAACCCCTTGGCGCAGGCTCGATCTCACGGAA
CTGGGGCAGCTCACCTTCCGAGCCCCGGATCCAGCCAAATACCCCTGCATGGATCTGGCCTATTCCGCCGGACGCGCCGG
CGGCACGATGCCGGCTGTGCTCAATGCCGCCAACGAGCAGGCGGTGGCCCTCTTCCTCGAGGAGCGCATCCATTTCCTCG
ATATCCCCAAGCTGATTGAGGCCGCCTGCGATCGCCACCGCAACGATCTCAAAGCCCAGCCCAGCCTCGATGATGTGCTT
GCTGTGGATCAATGGGCACGCCGCTTCGTACGAGACACCAGCAGCGTGCCGCTGGCGGCGTAA

Upstream 100 bases:

>100_bases
TGCCAGCCGCGGCCAGCACAAACCCAAGGCCTGAGCGCCACTTCTCCCGCGCTGCCATCCCTTCTCCCACCAGCCCAATG
CCGCGCCAGCCTGCCAGTGA

Downstream 100 bases:

>100_bases
CAACCAGCCGAAGAGATTCTGCAACCGTCAGGACTGGCCAGGCAGCGTCATTAGCAAGGCAATGAGAGAGTCTGAGCTAG
GCCATGTCCCTAAAAGCAGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MANSMGDWVPSKAVAVKALSVLGSTGSIGTQTLEIVEEFPERFRVVALTAGRNLALLCKQVQRHQPEVVALADPALLSEL
RERLQALNLPRCPELVAGNEGLCQAAAWSSADLVVTGIVGCAGLLPTLAAIEAGKDLALANKETLIAAGPVVLPALERSG
SRLLPADSEHSAIFQCLQGTPWADTARLSTGVPTPGLRRIQLTASGGAFRDWAAADLAKATVADATSHPNWSMGRKITVD
SASLMNKGLEVIEAHYLYGVDYDHIEIVIHPQSIIHSMVELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRLDLTE
LGQLTFRAPDPAKYPCMDLAYSAGRAGGTMPAVLNAANEQAVALFLEERIHFLDIPKLIEAACDRHRNDLKAQPSLDDVL
AVDQWARRFVRDTSSVPLAA

Sequences:

>Translated_420_residues
MANSMGDWVPSKAVAVKALSVLGSTGSIGTQTLEIVEEFPERFRVVALTAGRNLALLCKQVQRHQPEVVALADPALLSEL
RERLQALNLPRCPELVAGNEGLCQAAAWSSADLVVTGIVGCAGLLPTLAAIEAGKDLALANKETLIAAGPVVLPALERSG
SRLLPADSEHSAIFQCLQGTPWADTARLSTGVPTPGLRRIQLTASGGAFRDWAAADLAKATVADATSHPNWSMGRKITVD
SASLMNKGLEVIEAHYLYGVDYDHIEIVIHPQSIIHSMVELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRLDLTE
LGQLTFRAPDPAKYPCMDLAYSAGRAGGTMPAVLNAANEQAVALFLEERIHFLDIPKLIEAACDRHRNDLKAQPSLDDVL
AVDQWARRFVRDTSSVPLAA
>Mature_419_residues
ANSMGDWVPSKAVAVKALSVLGSTGSIGTQTLEIVEEFPERFRVVALTAGRNLALLCKQVQRHQPEVVALADPALLSELR
ERLQALNLPRCPELVAGNEGLCQAAAWSSADLVVTGIVGCAGLLPTLAAIEAGKDLALANKETLIAAGPVVLPALERSGS
RLLPADSEHSAIFQCLQGTPWADTARLSTGVPTPGLRRIQLTASGGAFRDWAAADLAKATVADATSHPNWSMGRKITVDS
ASLMNKGLEVIEAHYLYGVDYDHIEIVIHPQSIIHSMVELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRLDLTEL
GQLTFRAPDPAKYPCMDLAYSAGRAGGTMPAVLNAANEQAVALFLEERIHFLDIPKLIEAACDRHRNDLKAQPSLDDVLA
VDQWARRFVRDTSSVPLAA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=401, Percent_Identity=45.6359102244389, Blast_Score=320, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 45249; Mature: 45118

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSMGDWVPSKAVAVKALSVLGSTGSIGTQTLEIVEEFPERFRVVALTAGRNLALLCKQ
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHH
VQRHQPEVVALADPALLSELRERLQALNLPRCPELVAGNEGLCQAAAWSSADLVVTGIVG
HHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHCCCCCCHHHHHHHH
CAGLLPTLAAIEAGKDLALANKETLIAAGPVVLPALERSGSRLLPADSEHSAIFQCLQGT
HHHHHHHHHHHHCCCCEEECCCCEEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
PWADTARLSTGVPTPGLRRIQLTASGGAFRDWAAADLAKATVADATSHPNWSMGRKITVD
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
SASLMNKGLEVIEAHYLYGVDYDHIEIVIHPQSIIHSMVELADSSVLAQLGWPDMKLPIL
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
YCLSWPERLETPWRRLDLTELGQLTFRAPDPAKYPCMDLAYSAGRAGGTMPAVLNAANEQ
EECCCHHHHCCHHHHCCHHHHCCEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCHH
AVALFLEERIHFLDIPKLIEAACDRHRNDLKAQPSLDDVLAVDQWARRFVRDTSSVPLAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ANSMGDWVPSKAVAVKALSVLGSTGSIGTQTLEIVEEFPERFRVVALTAGRNLALLCKQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHH
VQRHQPEVVALADPALLSELRERLQALNLPRCPELVAGNEGLCQAAAWSSADLVVTGIVG
HHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHCCCCCCHHHHHHHH
CAGLLPTLAAIEAGKDLALANKETLIAAGPVVLPALERSGSRLLPADSEHSAIFQCLQGT
HHHHHHHHHHHHCCCCEEECCCCEEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
PWADTARLSTGVPTPGLRRIQLTASGGAFRDWAAADLAKATVADATSHPNWSMGRKITVD
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
SASLMNKGLEVIEAHYLYGVDYDHIEIVIHPQSIIHSMVELADSSVLAQLGWPDMKLPIL
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
YCLSWPERLETPWRRLDLTELGQLTFRAPDPAKYPCMDLAYSAGRAGGTMPAVLNAANEQ
EECCCHHHHCCHHHHCCHHHHCCEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCHH
AVALFLEERIHFLDIPKLIEAACDRHRNDLKAQPSLDDVLAVDQWARRFVRDTSSVPLAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA