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The map label for this gene is hemL

Identifier: 148242747

GI number: 148242747

Start: 1443516

End: 1444820

Strand: Direct

Name: hemL

Synonym: SynRCC307_1648

Alternate gene names: 148242747

Gene position: 1443516-1444820 (Clockwise)

Preceding gene: 148242745

Following gene: 148242748

Centisome position: 64.88

GC content: 64.21

Gene sequence:

>1305_bases
TTGGTGACTGCTGCAGCCCTGAACACCAGCCGTTCCGACGCCCTCTTTACGGCAGCGCAACAACTGATGCCCGGCGGTGT
GAATTCCCCGGTACGGGCCTTCCGCTCCGTGGGCGGCCAGCCGATCGTGTTCGATCGCGTCGAAGGCGCCTACGCCTGGG
ATGTGGATGGCAACCGCTACATCGATTACATCGGCAGCTGGGGACCTGCCATCTGCGGACACGCCAATCCCGAGGTGATC
GAGGCCCTGCAGCAGGCCCTCACCAAGGGCACCAGCTTTGGCGCCCCCTGCGCCCTGGAAAACACCCTCGCCGAGATGGT
GATCAACGCCGTCCCCAGCGTGGAGATGGTTCGCTTCGTCAACAGCGGCACCGAGGCCTGCATGGCCGTGCTGCGCCTGA
TGCGCGCCTACACCGGCCGCGAAAAGGTGATCAAGTTCGAGGGCTGCTACCACGGTCACGCCGACATGTTCCTGGTGAAG
GCCGGCTCTGGTGTCGCCACCTTGGGCCTGCCGGACTCCCCCGGCGTGCCGAGCAGCACCACCGCCAACACCCTTACCGC
CCCCTACAACGACCTTGAGGCGGTCAAGGCCCTGTTTGCCGAAAATCCCGACTCGATCTCCGGTGTGATCCTTGAGCCGG
TGGTGGGCAATGCCGGCTTTATCCCCCCCGATTTCGGCTTCCTCGAAGGTCTGCGGGAAATCACCCGTGAATACGGCGCC
CTGCTGGTGTTCGACGAAGTGATGACCGGCTTCCGCATCTCCTATGGCGGGGCCCAAGCCCGCTTTGGCATCACCCCCGA
CCTCACCACCATGGGCAAGGTGATTGGCGGCGGTCTGCCTGTGGGCGCCTACGGCGGCCGCAAGGACATCATGGAAATGG
TTGCCCCCGCTGGCCCGATGTATCAAGCGGGCACCCTCAGCGGAAACCCCTTGGCCATGACGGCGGGCATCAAGACCCTC
GAGCTGCTCAAGCGCCCTGGCACTTACGAAAAGCTCGAAGCCACCACCAAGCGTTTGGCTGAAGGCATCCAGGAAGCGGC
TAAAGCCGCTGGCCTGCCGGTGTGCGGCAACAGCATCAGTGCCATGTTCGGCTTCTTCCTCTGCGATGGCCCCGTGCGCA
ACTTCGAGGAGGCCAAAGCCAACGACAGCGAGCGCTTCGCCAAGCTGCACCGGGCCATGCTCGAGCGCGGGGTATACCTC
GCCCCCAGCTCCTTTGAAGCTGGCTTCACCTCGCTGGCCCACAGCGATGCCGACATTGATGCCACCCTCGAGGCCTTCCG
CGAAAGCTTCCAGCTGATCGCTTGA

Upstream 100 bases:

>100_bases
GTGGCCACGGAGATGAACAACTCGTTCAATTGAGCCTATCGATCGCAGAACAAAGCGGCGCCAGGGCAGAGTGGGAGGCT
CTGTCTCTGTTCATAACGCT

Downstream 100 bases:

>100_bases
GGCGCCGGATGCAGAGGCGCCAACTGATCCAAGCCGCCAGCCTCGCTGGCGGGGCAGGCCTGCTGAGTGCCTGCCGCATT
CGCCGCATCGATGGGGCCAG

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MVTAAALNTSRSDALFTAAQQLMPGGVNSPVRAFRSVGGQPIVFDRVEGAYAWDVDGNRYIDYIGSWGPAICGHANPEVI
EALQQALTKGTSFGAPCALENTLAEMVINAVPSVEMVRFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVK
AGSGVATLGLPDSPGVPSSTTANTLTAPYNDLEAVKALFAENPDSISGVILEPVVGNAGFIPPDFGFLEGLREITREYGA
LLVFDEVMTGFRISYGGAQARFGITPDLTTMGKVIGGGLPVGAYGGRKDIMEMVAPAGPMYQAGTLSGNPLAMTAGIKTL
ELLKRPGTYEKLEATTKRLAEGIQEAAKAAGLPVCGNSISAMFGFFLCDGPVRNFEEAKANDSERFAKLHRAMLERGVYL
APSSFEAGFTSLAHSDADIDATLEAFRESFQLIA

Sequences:

>Translated_434_residues
MVTAAALNTSRSDALFTAAQQLMPGGVNSPVRAFRSVGGQPIVFDRVEGAYAWDVDGNRYIDYIGSWGPAICGHANPEVI
EALQQALTKGTSFGAPCALENTLAEMVINAVPSVEMVRFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVK
AGSGVATLGLPDSPGVPSSTTANTLTAPYNDLEAVKALFAENPDSISGVILEPVVGNAGFIPPDFGFLEGLREITREYGA
LLVFDEVMTGFRISYGGAQARFGITPDLTTMGKVIGGGLPVGAYGGRKDIMEMVAPAGPMYQAGTLSGNPLAMTAGIKTL
ELLKRPGTYEKLEATTKRLAEGIQEAAKAAGLPVCGNSISAMFGFFLCDGPVRNFEEAKANDSERFAKLHRAMLERGVYL
APSSFEAGFTSLAHSDADIDATLEAFRESFQLIA
>Mature_434_residues
MVTAAALNTSRSDALFTAAQQLMPGGVNSPVRAFRSVGGQPIVFDRVEGAYAWDVDGNRYIDYIGSWGPAICGHANPEVI
EALQQALTKGTSFGAPCALENTLAEMVINAVPSVEMVRFVNSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVK
AGSGVATLGLPDSPGVPSSTTANTLTAPYNDLEAVKALFAENPDSISGVILEPVVGNAGFIPPDFGFLEGLREITREYGA
LLVFDEVMTGFRISYGGAQARFGITPDLTTMGKVIGGGLPVGAYGGRKDIMEMVAPAGPMYQAGTLSGNPLAMTAGIKTL
ELLKRPGTYEKLEATTKRLAEGIQEAAKAAGLPVCGNSISAMFGFFLCDGPVRNFEEAKANDSERFAKLHRAMLERGVYL
APSSFEAGFTSLAHSDADIDATLEAFRESFQLIA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=294, Percent_Identity=29.9319727891156, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI13994255, Length=327, Percent_Identity=26.2996941896024, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI24119277, Length=304, Percent_Identity=27.9605263157895, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI37574042, Length=334, Percent_Identity=27.5449101796407, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226442705, Length=333, Percent_Identity=26.4264264264264, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI226442709, Length=302, Percent_Identity=27.1523178807947, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI284507298, Length=145, Percent_Identity=34.4827586206897, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786349, Length=422, Percent_Identity=54.739336492891, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1788044, Length=307, Percent_Identity=34.8534201954397, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789016, Length=323, Percent_Identity=31.5789473684211, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789759, Length=312, Percent_Identity=31.4102564102564, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI145693181, Length=320, Percent_Identity=29.375, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787560, Length=316, Percent_Identity=30.379746835443, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786991, Length=371, Percent_Identity=24.5283018867925, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144271, Length=329, Percent_Identity=26.7477203647416, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=360, Percent_Identity=26.9444444444444, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=176, Percent_Identity=30.1136363636364, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=305, Percent_Identity=27.5409836065574, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=313, Percent_Identity=25.2396166134185, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21357415, Length=294, Percent_Identity=25.8503401360544, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356575, Length=317, Percent_Identity=28.0757097791798, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_SYNR3 (A5GUJ2)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227904.1
- ProteinModelPortal:   A5GUJ2
- SMR:   A5GUJ2
- STRING:   A5GUJ2
- GeneID:   5157555
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_1648
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45954; Mature: 45954

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTAAALNTSRSDALFTAAQQLMPGGVNSPVRAFRSVGGQPIVFDRVEGAYAWDVDGNRY
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCEEEEECCCCCE
IDYIGSWGPAICGHANPEVIEALQQALTKGTSFGAPCALENTLAEMVINAVPSVEMVRFV
EHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
NSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPSST
HCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCC
TANTLTAPYNDLEAVKALFAENPDSISGVILEPVVGNAGFIPPDFGFLEGLREITREYGA
CCCCEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
LLVFDEVMTGFRISYGGAQARFGITPDLTTMGKVIGGGLPVGAYGGRKDIMEMVAPAGPM
EEEEHHHHHCEEEEECCCCEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCC
YQAGTLSGNPLAMTAGIKTLELLKRPGTYEKLEATTKRLAEGIQEAAKAAGLPVCGNSIS
CCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AMFGFFLCDGPVRNFEEAKANDSERFAKLHRAMLERGVYLAPSSFEAGFTSLAHSDADID
HHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHCCCCCHH
ATLEAFRESFQLIA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MVTAAALNTSRSDALFTAAQQLMPGGVNSPVRAFRSVGGQPIVFDRVEGAYAWDVDGNRY
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCEEEEECCCCCE
IDYIGSWGPAICGHANPEVIEALQQALTKGTSFGAPCALENTLAEMVINAVPSVEMVRFV
EHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
NSGTEACMAVLRLMRAYTGREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPSST
HCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCC
TANTLTAPYNDLEAVKALFAENPDSISGVILEPVVGNAGFIPPDFGFLEGLREITREYGA
CCCCEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
LLVFDEVMTGFRISYGGAQARFGITPDLTTMGKVIGGGLPVGAYGGRKDIMEMVAPAGPM
EEEEHHHHHCEEEEECCCCEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCC
YQAGTLSGNPLAMTAGIKTLELLKRPGTYEKLEATTKRLAEGIQEAAKAAGLPVCGNSIS
CCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AMFGFFLCDGPVRNFEEAKANDSERFAKLHRAMLERGVYLAPSSFEAGFTSLAHSDADID
HHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHCCCCCHH
ATLEAFRESFQLIA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA