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The map label for this gene is upp [H]

Identifier: 148242345

GI number: 148242345

Start: 1102521

End: 1103192

Strand: Direct

Name: upp [H]

Synonym: SynRCC307_1246

Alternate gene names: 148242345

Gene position: 1102521-1103192 (Clockwise)

Preceding gene: 148242341

Following gene: 148242346

Centisome position: 49.55

GC content: 62.05

Gene sequence:

>672_bases
ATGCCCTCCTCCTTTCGTGTGGTGGTGCCCCCCCATCCGTTGGTGGCCCACTGGCTCACAGTGCTGCGCGACAAGCAAAC
CCCCTCGCCGTTGTTCGCAACAGCGATGAAAGAGCTGGGCCGCTGGCTCACCTATGAGGCAGCCCGCGATTGGTTGCCCC
AGCGCAACATCACAGTTGAAACGCCTTTGGCCAGTTGTGAGGGCCAAGTGATGGACCCCACAACCCCGGTGCTCGCCATC
CCAATCCTGCGCGCTGGTTTGGGACTCTGGGCTGGCGGGCAAGACGTTCTGCCCCATGCGCGGGTTGCCCATATGGGTGT
GGTGCGTGATGAGGCAACGGCGCAGGCCAGCAGCTATCTCGACCGCATGCCCAAGCGCATTGGCGAGCGGGTGGGCGTGA
TGGTGTTCGATCCGATGGTCGCCACTGGTGGCAGCTTGGCGATGGTGCTCCGCCAACTCAAGGAGCTTGGGGTGCATGGA
TCGCGTCTGCGGGTGATCACCGCTCTGGCCTCCTCACCAGGGCTCAAAAGCCTGGCTGAGGAATTTCAGGACCTCACCCT
CTACACCGGTTGCATTGATGCCGAACTCGATGAACGGAACTACATCGTGCCTGGACTAGGCGATGCGGGCGATCGTCTTT
ACGGCACAGAGTCGGAGGACTTCCTAGCCTGA

Upstream 100 bases:

>100_bases
GCTCCAGGCCACTGCAAGAGCAACACCAACAACATCGCGGTGGCCGACAGCAAAAAGCGCCGCATGAATCCCCGTAGGCT
TGGCGCACAAGCTAGGTGAA

Downstream 100 bases:

>100_bases
TAGGGACAACGTTTTGAGCATGGCTGAACAAAACAGCAGCTCCGCATCGCTTCTTCTCAGCGCGCTCACCGGTGCGGCGG
TTGGCGCTGCAGGTCTGACC

Product: Uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MPSSFRVVVPPHPLVAHWLTVLRDKQTPSPLFATAMKELGRWLTYEAARDWLPQRNITVETPLASCEGQVMDPTTPVLAI
PILRAGLGLWAGGQDVLPHARVAHMGVVRDEATAQASSYLDRMPKRIGERVGVMVFDPMVATGGSLAMVLRQLKELGVHG
SRLRVITALASSPGLKSLAEEFQDLTLYTGCIDAELDERNYIVPGLGDAGDRLYGTESEDFLA

Sequences:

>Translated_223_residues
MPSSFRVVVPPHPLVAHWLTVLRDKQTPSPLFATAMKELGRWLTYEAARDWLPQRNITVETPLASCEGQVMDPTTPVLAI
PILRAGLGLWAGGQDVLPHARVAHMGVVRDEATAQASSYLDRMPKRIGERVGVMVFDPMVATGGSLAMVLRQLKELGVHG
SRLRVITALASSPGLKSLAEEFQDLTLYTGCIDAELDERNYIVPGLGDAGDRLYGTESEDFLA
>Mature_222_residues
PSSFRVVVPPHPLVAHWLTVLRDKQTPSPLFATAMKELGRWLTYEAARDWLPQRNITVETPLASCEGQVMDPTTPVLAIP
ILRAGLGLWAGGQDVLPHARVAHMGVVRDEATAQASSYLDRMPKRIGERVGVMVFDPMVATGGSLAMVLRQLKELGVHGS
RLRVITALASSPGLKSLAEEFQDLTLYTGCIDAELDERNYIVPGLGDAGDRLYGTESEDFLA

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=211, Percent_Identity=27.0142180094787, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI57863312, Length=211, Percent_Identity=27.0142180094787, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI87082118, Length=218, Percent_Identity=35.7798165137615, Blast_Score=136, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17539892, Length=210, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=210, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=196, Percent_Identity=33.6734693877551, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45550449, Length=221, Percent_Identity=30.316742081448, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28573516, Length=221, Percent_Identity=30.316742081448, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28573514, Length=221, Percent_Identity=30.316742081448, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28573512, Length=221, Percent_Identity=30.316742081448, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24301; Mature: 24170

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSFRVVVPPHPLVAHWLTVLRDKQTPSPLFATAMKELGRWLTYEAARDWLPQRNITVE
CCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
TPLASCEGQVMDPTTPVLAIPILRAGLGLWAGGQDVLPHARVAHMGVVRDEATAQASSYL
CCCCCCCCCEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DRMPKRIGERVGVMVFDPMVATGGSLAMVLRQLKELGVHGSRLRVITALASSPGLKSLAE
HHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHH
EFQDLTLYTGCIDAELDERNYIVPGLGDAGDRLYGTESEDFLA
HHHHHHHHHCEECCCCCCCCEECCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
PSSFRVVVPPHPLVAHWLTVLRDKQTPSPLFATAMKELGRWLTYEAARDWLPQRNITVE
CCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
TPLASCEGQVMDPTTPVLAIPILRAGLGLWAGGQDVLPHARVAHMGVVRDEATAQASSYL
CCCCCCCCCEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DRMPKRIGERVGVMVFDPMVATGGSLAMVLRQLKELGVHGSRLRVITALASSPGLKSLAE
HHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHH
EFQDLTLYTGCIDAELDERNYIVPGLGDAGDRLYGTESEDFLA
HHHHHHHHHCEECCCCCCCCEECCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]