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The map label for this gene is preA [H]

Identifier: 148242258

GI number: 148242258

Start: 1025614

End: 1026585

Strand: Direct

Name: preA [H]

Synonym: SynRCC307_1159

Alternate gene names: 148242258

Gene position: 1025614-1026585 (Clockwise)

Preceding gene: 148242257

Following gene: 148242260

Centisome position: 46.1

GC content: 58.74

Gene sequence:

>972_bases
ATGTCGACGGTTGCCCAGCTTCTTCAGCCCGTCGAGTCTGACCTCGAGCAGCTTCTCAGCGATTTGCGCGCCTTAATCGG
CGCCGGTCACCCCATTCTTCAGGCGGCAGCTGAGCATCTCTTCAGTGCCGGCGGTAAGCGCTTACGGCCCGGAATTGTCT
TGTTGCTGAGCCGGGCCCTGGATCCCGCTGGTGAGCTCAGCCTGCGCCACCGGCGCCTGGCCCAGATCACCGAGATGATC
CACACGGCCTCGCTGGTTCACGACGATGTTGTCGATGAGGCCAATACCCGCCGCGGTGTGCCCACGGTTCACAGCCGTTT
CAACAGTCGTGTGGCGGTGTTAGCCGGTGATTTTCTGTTTGCCCAGTCCAGTTGGCATCTCGCCAATTTGGATGACCTTG
AAGTGGTCAAGCTGCTCAGCCGCGTGATCATGGATCTGGCGGAAGGTGAAATCCGTCAGGGTCTATTCCGCTACGACACC
GGTCAAAGCCTCGAGACCTATCTCGAAAAGAGCTATTGGAAAACAGCGTCTTTGATCGCCAACAGCGCTAAAGCCGCTGG
TGTGCTCTCAGAGCTCGAGCGCGATCAGCTCAACCAGCTGCACAGCTTTGGTCGTCAACTTGGTCTGGCTTTTCAAATCG
TGGACGACATCCTCGACTTCACGGGCAGTGACGATCAGCTTGGTAAGCCAGCTGCTTCCGATTTGGCGTCTGGAACCCTC
ACAGCCCCAGTGATCTATGCCATGGAGGAGCACCCCTCCTTGGCGGTGTTGATTGAGCGGGAGTTCAGCGAACCCGACGA
TCTCGATCAAGCTTTGGGCCTTGTGCGTCAGAGCCAGGGCATCCAGCGGGCGAGGGCCCTAGCTGAATCCATGGCCCGTG
AATCCACCACCAATCTCAAGTTCCTGCCGGCGAGCGCTTCGCGTGATGCCTTGATGGAGCTCCCGGACTTTGTGCTGAGC
CGGCTGTACTAA

Upstream 100 bases:

>100_bases
CAGGATCGGCCCGTTGGTTGGGTCAACGGCCCCCGGTTGAGCAGATTTCTCTCCAGCCAGAGGGTCACGGCCACTAGGAT
CGGCTCACTCAGGCGGAGCC

Downstream 100 bases:

>100_bases
GCCGCTCTATTGCTGGCGGTAGCGGGGCAACTCATCGCCAATGGTGAACAGAGGTTTGTTCTTTTTGAACCACAGCCAAT
CCCGTAAAGGAGGCGTTGTG

Product: prenyl transferase

Products: diphosphate; all-trans-nonaprenyl diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSTVAQLLQPVESDLEQLLSDLRALIGAGHPILQAAAEHLFSAGGKRLRPGIVLLLSRALDPAGELSLRHRRLAQITEMI
HTASLVHDDVVDEANTRRGVPTVHSRFNSRVAVLAGDFLFAQSSWHLANLDDLEVVKLLSRVIMDLAEGEIRQGLFRYDT
GQSLETYLEKSYWKTASLIANSAKAAGVLSELERDQLNQLHSFGRQLGLAFQIVDDILDFTGSDDQLGKPAASDLASGTL
TAPVIYAMEEHPSLAVLIEREFSEPDDLDQALGLVRQSQGIQRARALAESMARESTTNLKFLPASASRDALMELPDFVLS
RLY

Sequences:

>Translated_323_residues
MSTVAQLLQPVESDLEQLLSDLRALIGAGHPILQAAAEHLFSAGGKRLRPGIVLLLSRALDPAGELSLRHRRLAQITEMI
HTASLVHDDVVDEANTRRGVPTVHSRFNSRVAVLAGDFLFAQSSWHLANLDDLEVVKLLSRVIMDLAEGEIRQGLFRYDT
GQSLETYLEKSYWKTASLIANSAKAAGVLSELERDQLNQLHSFGRQLGLAFQIVDDILDFTGSDDQLGKPAASDLASGTL
TAPVIYAMEEHPSLAVLIEREFSEPDDLDQALGLVRQSQGIQRARALAESMARESTTNLKFLPASASRDALMELPDFVLS
RLY
>Mature_322_residues
STVAQLLQPVESDLEQLLSDLRALIGAGHPILQAAAEHLFSAGGKRLRPGIVLLLSRALDPAGELSLRHRRLAQITEMIH
TASLVHDDVVDEANTRRGVPTVHSRFNSRVAVLAGDFLFAQSSWHLANLDDLEVVKLLSRVIMDLAEGEIRQGLFRYDTG
QSLETYLEKSYWKTASLIANSAKAAGVLSELERDQLNQLHSFGRQLGLAFQIVDDILDFTGSDDQLGKPAASDLASGTLT
APVIYAMEEHPSLAVLIEREFSEPDDLDQALGLVRQSQGIQRARALAESMARESTTNLKFLPASASRDALMELPDFVLSR
LY

Specific function: Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=313, Percent_Identity=40.8945686900958, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI169808399, Length=335, Percent_Identity=27.1641791044776, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4758430, Length=226, Percent_Identity=27.4336283185841, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI83700220, Length=226, Percent_Identity=27.4336283185841, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789578, Length=311, Percent_Identity=33.4405144694534, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786623, Length=222, Percent_Identity=32.8828828828829, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17505681, Length=328, Percent_Identity=34.4512195121951, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319475, Length=298, Percent_Identity=38.5906040268456, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6325188, Length=251, Percent_Identity=22.7091633466135, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651612, Length=319, Percent_Identity=37.3040752351097, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI21356309, Length=363, Percent_Identity=26.1707988980716, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281365769, Length=275, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24660002, Length=275, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR014120
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: 2.5.1.11

Molecular weight: Translated: 35419; Mature: 35287

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVAQLLQPVESDLEQLLSDLRALIGAGHPILQAAAEHLFSAGGKRLRPGIVLLLSRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
DPAGELSLRHRRLAQITEMIHTASLVHDDVVDEANTRRGVPTVHSRFNSRVAVLAGDFLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHH
AQSSWHLANLDDLEVVKLLSRVIMDLAEGEIRQGLFRYDTGQSLETYLEKSYWKTASLIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NSAKAAGVLSELERDQLNQLHSFGRQLGLAFQIVDDILDFTGSDDQLGKPAASDLASGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCH
TAPVIYAMEEHPSLAVLIEREFSEPDDLDQALGLVRQSQGIQRARALAESMARESTTNLK
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FLPASASRDALMELPDFVLSRLY
EEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STVAQLLQPVESDLEQLLSDLRALIGAGHPILQAAAEHLFSAGGKRLRPGIVLLLSRAL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
DPAGELSLRHRRLAQITEMIHTASLVHDDVVDEANTRRGVPTVHSRFNSRVAVLAGDFLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHH
AQSSWHLANLDDLEVVKLLSRVIMDLAEGEIRQGLFRYDTGQSLETYLEKSYWKTASLIA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NSAKAAGVLSELERDQLNQLHSFGRQLGLAFQIVDDILDFTGSDDQLGKPAASDLASGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCH
TAPVIYAMEEHPSLAVLIEREFSEPDDLDQALGLVRQSQGIQRARALAESMARESTTNLK
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FLPASASRDALMELPDFVLSRLY
EEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: all-trans-octaprenyl diphosphate; isopentenyl diphosphate

Specific reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]