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The map label for this gene is apt

Identifier: 148242065

GI number: 148242065

Start: 884506

End: 885039

Strand: Direct

Name: apt

Synonym: SynRCC307_0966

Alternate gene names: 148242065

Gene position: 884506-885039 (Clockwise)

Preceding gene: 148242060

Following gene: 148242070

Centisome position: 39.75

GC content: 63.11

Gene sequence:

>534_bases
ATGGCCGAGAGCCTTGAGCAGCAACTACGTGCCCTGGTCAGGGATGTGCCGGATTTCCCGAAGCCAGGAATTTTGTTCCG
TGACCTCACACCGGTCATGCGCGATCCCCAGGCTTGGAAGCAAGTGATGGAGGGGATGCAGCAGTCTTTGGCTGGCTTGC
AGCCTGAGGTGATTGTGGGGATTGAGGCGCGGGGCTTCATCGTTGGCACCAGCCTGGCGATGACGATGGGCCTGGGCTTT
GTGCCCGTGCGTAAGCCCGGCAAACTCCCTGGTCCGATCACTGCTGTGGACTATGCCCTCGAGTACGGCAGCGACCGGCT
GGAGATCCAAGAGGGGGCCTTGAGCGGCTGCCAGCGCGTGTTGGTGGTCGATGATCTGCTGGCCACTGGCGGCACTGCGG
CAGCCTGCGCGGAACTGGTGAGCCGAGCTGGCGGGGCCGTGTGCGGTTACGGCTTTGTGGCTGAGCTCACAGCCCTTGGC
GGCCGCAGCAAACTCCCCGGAGGCGTGCTGGTGGAGTCACTGATTCATTACTGA

Upstream 100 bases:

>100_bases
GTGGCAGGCGCTGCTGTTGCGATCAAGGACCGGGGGCAATGGCTGAGATGATGCCAGTTGAGGCCTTGTGCCGTCACCTC
TTTGTTAGGAGCCTCCATCC

Downstream 100 bases:

>100_bases
GGTCAGCTTTGACCGTCTTGCCAATCGAGCACTTGGTCGAGTTGTCCCAGGTTGAGCAAACCAAAACGCCAGAGGGTCAC
CGGCAGCGGGGCCTGCTCTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MAESLEQQLRALVRDVPDFPKPGILFRDLTPVMRDPQAWKQVMEGMQQSLAGLQPEVIVGIEARGFIVGTSLAMTMGLGF
VPVRKPGKLPGPITAVDYALEYGSDRLEIQEGALSGCQRVLVVDDLLATGGTAAACAELVSRAGGAVCGYGFVAELTALG
GRSKLPGGVLVESLIHY

Sequences:

>Translated_177_residues
MAESLEQQLRALVRDVPDFPKPGILFRDLTPVMRDPQAWKQVMEGMQQSLAGLQPEVIVGIEARGFIVGTSLAMTMGLGF
VPVRKPGKLPGPITAVDYALEYGSDRLEIQEGALSGCQRVLVVDDLLATGGTAAACAELVSRAGGAVCGYGFVAELTALG
GRSKLPGGVLVESLIHY
>Mature_176_residues
AESLEQQLRALVRDVPDFPKPGILFRDLTPVMRDPQAWKQVMEGMQQSLAGLQPEVIVGIEARGFIVGTSLAMTMGLGFV
PVRKPGKLPGPITAVDYALEYGSDRLEIQEGALSGCQRVLVVDDLLATGGTAAACAELVSRAGGAVCGYGFVAELTALGG
RSKLPGGVLVESLIHY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=180, Percent_Identity=46.1111111111111, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=48.1203007518797, Blast_Score=123, Evalue=1e-28,
Organism=Escherichia coli, GI1786675, Length=177, Percent_Identity=44.0677966101695, Blast_Score=146, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=179, Percent_Identity=41.8994413407821, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=44.7674418604651, Blast_Score=138, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320649, Length=180, Percent_Identity=33.8888888888889, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136334, Length=178, Percent_Identity=42.6966292134831, Blast_Score=137, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SYNR3 (A5GSL0)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227222.1
- ProteinModelPortal:   A5GSL0
- SMR:   A5GSL0
- STRING:   A5GSL0
- GeneID:   5157901
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_0966
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18654; Mature: 18523

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESLEQQLRALVRDVPDFPKPGILFRDLTPVMRDPQAWKQVMEGMQQSLAGLQPEVIVG
CCHHHHHHHHHHHHHCCCCCCCCEEHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEEE
IEARGFIVGTSLAMTMGLGFVPVRKPGKLPGPITAVDYALEYGSDRLEIQEGALSGCQRV
ECCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVVDDLLATGGTAAACAELVSRAGGAVCGYGFVAELTALGGRSKLPGGVLVESLIHY
HHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AESLEQQLRALVRDVPDFPKPGILFRDLTPVMRDPQAWKQVMEGMQQSLAGLQPEVIVG
CHHHHHHHHHHHHHCCCCCCCCEEHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEEE
IEARGFIVGTSLAMTMGLGFVPVRKPGKLPGPITAVDYALEYGSDRLEIQEGALSGCQRV
ECCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVVDDLLATGGTAAACAELVSRAGGAVCGYGFVAELTALGGRSKLPGGVLVESLIHY
HHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA