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The map label for this gene is folD

Identifier: 148241848

GI number: 148241848

Start: 678736

End: 679614

Strand: Direct

Name: folD

Synonym: SynRCC307_0749

Alternate gene names: 148241848

Gene position: 678736-679614 (Clockwise)

Preceding gene: 148241846

Following gene: 148241849

Centisome position: 30.51

GC content: 65.53

Gene sequence:

>879_bases
ATGCCAGCCCAGCGTCTTGATGGCCGCCAGTTGGCGGCTCAGCTCGAGGAGGTGATGGCCGCGGCAATCGCTTCTGGTTT
GCCGCGCGCTGGCCGGCCGCCTGGCTTGGCGGTGCTGCGTGTTGGCGACGATCCGGCAAGCGGTGTGTATGTGGCCAATA
AAGAGAAAGCCTGCGCCCGTGTGGGCTTGGTGAGCCATGGCGCCCACCTCGATGCAGCCACCCCCCAGGCCGAGATTGAG
GCCAAGTTGCGGCAGTTGAACCAGGATCCCGCCGTCGATGGAATCCTCGTGCAGTTGCCGGTGCCCGCTGGTCTGGATGA
TCGGGCCCTGCTGCTGGAGCTGGATCCAGCCAAAGACGCCGATGGTCTGCATCCGCTCAATCTGGGCCGCTTGTTGCGGG
GAGAGCCCGGTCCGCGCAGCTGCACGCCGGCTGGGGTGATGGCCCTGCTGCGCAGCAACGGCATCGATCCCGCTGGCAAA
CGGGCCGTGGTGATTGGCCGCAGCATCCTGGTGGGCCAGCCGATGGCGCTGATGTTGCAAGCGGCCAATGCCACGGTCAC
GGTGGTGCATTCGCGAACTGCTGATTTAGCGGCCCACACCCGTGAAGCCGAGATTTTGGTGGTGGCTGCCGGCAAGCCAG
GGATGATCGGCGCCGATCATGTGCGCCCTGGAGCCGCGGTGGTGGATGTGGGGATTCACCGCAAGCCGGAAGGAGGGTTA
TGCGGGGATGTGCGCTCTGCCGAGGTGGAGCCCATCGCCTCAGCCCTATCGCCTGTGCCCGGCGGAGTGGGGCCGATGAC
GGTGACGATGCTGCTGCTCAATACCGTGCGGGCTTGGAGCCAGCGGTTTGATCTGCCGGATCCAACCCCTGGTTATTAA

Upstream 100 bases:

>100_bases
AGGCCCGCCCAAGGCGCGGCCGAAAGCTCCAGAACCAACGTGAGAGGGCGGAGAGCACAGCGCGGCTGAGGTCAGACTGA
CGCTAGCTCCCATCACCGGA

Downstream 100 bases:

>100_bases
GGGCGCTGCGGGCTTAAGGTTTCCTTTAGATCCTTCTGCTTGTGGGGTGCCGCCATGGCTCAACCCCGGTTTTCATTCTC
CTCAGGGTTGTCGGCCGATG

Product: FolD bifunctional protein (PPDC) (methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase)

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MPAQRLDGRQLAAQLEEVMAAAIASGLPRAGRPPGLAVLRVGDDPASGVYVANKEKACARVGLVSHGAHLDAATPQAEIE
AKLRQLNQDPAVDGILVQLPVPAGLDDRALLLELDPAKDADGLHPLNLGRLLRGEPGPRSCTPAGVMALLRSNGIDPAGK
RAVVIGRSILVGQPMALMLQAANATVTVVHSRTADLAAHTREAEILVVAAGKPGMIGADHVRPGAAVVDVGIHRKPEGGL
CGDVRSAEVEPIASALSPVPGGVGPMTVTMLLLNTVRAWSQRFDLPDPTPGY

Sequences:

>Translated_292_residues
MPAQRLDGRQLAAQLEEVMAAAIASGLPRAGRPPGLAVLRVGDDPASGVYVANKEKACARVGLVSHGAHLDAATPQAEIE
AKLRQLNQDPAVDGILVQLPVPAGLDDRALLLELDPAKDADGLHPLNLGRLLRGEPGPRSCTPAGVMALLRSNGIDPAGK
RAVVIGRSILVGQPMALMLQAANATVTVVHSRTADLAAHTREAEILVVAAGKPGMIGADHVRPGAAVVDVGIHRKPEGGL
CGDVRSAEVEPIASALSPVPGGVGPMTVTMLLLNTVRAWSQRFDLPDPTPGY
>Mature_291_residues
PAQRLDGRQLAAQLEEVMAAAIASGLPRAGRPPGLAVLRVGDDPASGVYVANKEKACARVGLVSHGAHLDAATPQAEIEA
KLRQLNQDPAVDGILVQLPVPAGLDDRALLLELDPAKDADGLHPLNLGRLLRGEPGPRSCTPAGVMALLRSNGIDPAGKR
AVVIGRSILVGQPMALMLQAANATVTVVHSRTADLAAHTREAEILVVAAGKPGMIGADHVRPGAAVVDVGIHRKPEGGLC
GDVRSAEVEPIASALSPVPGGVGPMTVTMLLLNTVRAWSQRFDLPDPTPGY

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=293, Percent_Identity=38.5665529010239, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI222418558, Length=288, Percent_Identity=40.2777777777778, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI94721354, Length=299, Percent_Identity=39.1304347826087, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI36796743, Length=198, Percent_Identity=26.7676767676768, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786741, Length=287, Percent_Identity=45.6445993031359, Blast_Score=245, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17568735, Length=258, Percent_Identity=37.984496124031, Blast_Score=160, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321643, Length=301, Percent_Identity=38.8704318936877, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=39.0243902439024, Blast_Score=176, Evalue=4e-45,
Organism=Drosophila melanogaster, GI17136816, Length=298, Percent_Identity=44.9664429530201, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI17136818, Length=298, Percent_Identity=44.9664429530201, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24645718, Length=291, Percent_Identity=42.2680412371134, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17137370, Length=291, Percent_Identity=42.2680412371134, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62472483, Length=291, Percent_Identity=42.2680412371134, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45551871, Length=291, Percent_Identity=42.2680412371134, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_SYNR3 (A5GRZ3)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227005.1
- ProteinModelPortal:   A5GRZ3
- SMR:   A5GRZ3
- STRING:   A5GRZ3
- GeneID:   5158384
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_0749
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   CTPLGCI
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30118; Mature: 29987

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQRLDGRQLAAQLEEVMAAAIASGLPRAGRPPGLAVLRVGDDPASGVYVANKEKACAR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCHHHHH
VGLVSHGAHLDAATPQAEIEAKLRQLNQDPAVDGILVQLPVPAGLDDRALLLELDPAKDA
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCC
DGLHPLNLGRLLRGEPGPRSCTPAGVMALLRSNGIDPAGKRAVVIGRSILVGQPMALMLQ
CCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHCCCHHHEEE
AANATVTVVHSRTADLAAHTREAEILVVAAGKPGMIGADHVRPGAAVVDVGIHRKPEGGL
ECCCEEEEEECCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCEECCCCCC
CGDVRSAEVEPIASALSPVPGGVGPMTVTMLLLNTVRAWSQRFDLPDPTPGY
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PAQRLDGRQLAAQLEEVMAAAIASGLPRAGRPPGLAVLRVGDDPASGVYVANKEKACAR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCHHHHH
VGLVSHGAHLDAATPQAEIEAKLRQLNQDPAVDGILVQLPVPAGLDDRALLLELDPAKDA
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCC
DGLHPLNLGRLLRGEPGPRSCTPAGVMALLRSNGIDPAGKRAVVIGRSILVGQPMALMLQ
CCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHCCCHHHEEE
AANATVTVVHSRTADLAAHTREAEILVVAAGKPGMIGADHVRPGAAVVDVGIHRKPEGGL
ECCCEEEEEECCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCEECCCCCC
CGDVRSAEVEPIASALSPVPGGVGPMTVTMLLLNTVRAWSQRFDLPDPTPGY
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA