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The map label for this gene is folK [H]

Identifier: 148241322

GI number: 148241322

Start: 224187

End: 224717

Strand: Direct

Name: folK [H]

Synonym: SynRCC307_0223

Alternate gene names: 148241322

Gene position: 224187-224717 (Clockwise)

Preceding gene: 148241319

Following gene: 148241323

Centisome position: 10.08

GC content: 65.16

Gene sequence:

>531_bases
ATGCCGTTGTGCCGCAAAACCAGTGCGGTGGCGTTGGGCAGCAACCTGGGTGATTCGTTGGAGCTGCTGAGCACAGCGGC
CCAGGCCCTGCAGCAGTTGGCCGCGGCAGGTTCGTTTCGCTGCTCGCCGCTGTTCCGCACCGCTCCAGTGGGCGGGCCGG
TGGACCAGCCTGACTTCATCAATGCGGTGGTGCTGCTGGATTGGCAGGACACTCCTGAGCAATTGCTTCAGCAGCTGCAG
CAGCTGGAGGCCGCTGCTGGCCGGCAGCGCTTGATCGCCAATGGCCCGCGCTCATTGGATCTCGATTTGCTCTGGTGCGG
CATGGAGCAACGCTGCAGCGCTTTCCTCGAGCTGCCCCATCCGCGCTTGGCCCAGCGCCGTTTTGTGCTGCAGCCCTTGG
CGGCGCTGGATCCAACGTTGGTGCCGCCAGGGCAGGGTCTCAGTGTTTCAGCTTTGCTGGCGCGGGTTGAGCAACTGGGC
GAGGAGCCGCCGCCAGAGCAGCTTCAATTCCCCCACAGCTGGCCCGGTTGA

Upstream 100 bases:

>100_bases
AGCGGACCTTCGTGGTGATCCACCGCCCGGCGTTGGGCGTCATTGAGGCCGGCGAGGAAGCTCATGCAGCGAGACTATCG
ATCTCTCGCAGCTGCCAGTG

Downstream 100 bases:

>100_bases
GCCGGCAGACTGAGCTCCGCCTTTTGGAGCAGCCGTGTCTCCTTTGCCTGCGCCAGAGCCTTCTGAACTGCTCGACACCG
TGGCCACCCTGGCAGTGCGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MPLCRKTSAVALGSNLGDSLELLSTAAQALQQLAAAGSFRCSPLFRTAPVGGPVDQPDFINAVVLLDWQDTPEQLLQQLQ
QLEAAAGRQRLIANGPRSLDLDLLWCGMEQRCSAFLELPHPRLAQRRFVLQPLAALDPTLVPPGQGLSVSALLARVEQLG
EEPPPEQLQFPHSWPG

Sequences:

>Translated_176_residues
MPLCRKTSAVALGSNLGDSLELLSTAAQALQQLAAAGSFRCSPLFRTAPVGGPVDQPDFINAVVLLDWQDTPEQLLQQLQ
QLEAAAGRQRLIANGPRSLDLDLLWCGMEQRCSAFLELPHPRLAQRRFVLQPLAALDPTLVPPGQGLSVSALLARVEQLG
EEPPPEQLQFPHSWPG
>Mature_175_residues
PLCRKTSAVALGSNLGDSLELLSTAAQALQQLAAAGSFRCSPLFRTAPVGGPVDQPDFINAVVLLDWQDTPEQLLQQLQQ
LEAAAGRQRLIANGPRSLDLDLLWCGMEQRCSAFLELPHPRLAQRRFVLQPLAALDPTLVPPGQGLSVSALLARVEQLGE
EPPPEQLQFPHSWPG

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324073, Length=137, Percent_Identity=32.1167883211679, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19044; Mature: 18913

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLCRKTSAVALGSNLGDSLELLSTAAQALQQLAAAGSFRCSPLFRTAPVGGPVDQPDFI
CCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCC
NAVVLLDWQDTPEQLLQQLQQLEAAAGRQRLIANGPRSLDLDLLWCGMEQRCSAFLELPH
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCHHHHHHHHHCCCC
PRLAQRRFVLQPLAALDPTLVPPGQGLSVSALLARVEQLGEEPPPEQLQFPHSWPG
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
PLCRKTSAVALGSNLGDSLELLSTAAQALQQLAAAGSFRCSPLFRTAPVGGPVDQPDFI
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCC
NAVVLLDWQDTPEQLLQQLQQLEAAAGRQRLIANGPRSLDLDLLWCGMEQRCSAFLELPH
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCHHHHHHHHHCCCC
PRLAQRRFVLQPLAALDPTLVPPGQGLSVSALLARVEQLGEEPPPEQLQFPHSWPG
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]