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The map label for this gene is mutY [H]

Identifier: 148241202

GI number: 148241202

Start: 100926

End: 102086

Strand: Direct

Name: mutY [H]

Synonym: SynRCC307_0103

Alternate gene names: 148241202

Gene position: 100926-102086 (Clockwise)

Preceding gene: 148241201

Following gene: 148241203

Centisome position: 4.54

GC content: 59.52

Gene sequence:

>1161_bases
GTGATTATGAGAATTTTGCCTATCAATAGTCTCCTGCGTAGCGTTAATTTCGCTCCCTGTGTAACTAGCTATCTCCAGCT
TTCTTTGTTGATCTGGTCTGAGCAATTTGGTCGTAAGGCTATCCCTTGGAAGCATGCTAATACTTCTGGTCTTTTGGATA
TTTACGGCATTTGGATCGCTGAGGTGATGCTGCAGCAAACCCAGCTGCAGGTGGCGCTGCCCTATTGGCAGCGCTGGATG
CAGGCGCTCCCCACTGTTGATGCCTTAGCCGCTGCTGATGAGCAGCAGGTTCTCTTGCTCTGGCAGGGCCTTGGCTATTA
CTCACGTGCGCGGCGCTTGCATCAGGCGGCGCAGCAACTTCAAGGCCAGCCCTGGCCCCAAGATCTTGAAGCTTGGCTTG
CCCTCCCCGGCATTGGCCGCAGCACCGCCGGCAGCATTTTGAGCTCAGCCTTTGATCGGCCCTTCGCGATCCTCGATGGC
AATGTCAAACGCGTCTTGGCGCGGCTGACCGCCTTTGAGCATCCGCCTGCTCGCCATAGCGCTCATTTTTGGAGTCTTTC
TGAGCAGCTGCTGGATCGGCAACGGCCCCGTGATTTCAACCAGGCGCTGATGGATTTGGGGGCCACGCTGTGCACCCCCC
GCCAGCCGGACTGCCCCCGCTGCCCCTGGCAATCCCACTGCTCTGCTTACGCTGCCGGCTCCCCCGAACAATTCCCCGTG
AAGGAGTCGCCCAAGCCGCTGCCCTTGCAGGTCATTGGTGTGGGTGTGGTGCTCAATGAAGCCGGCGAGGTCTTGATTGA
TCAGCGCCTCAATGAAGGTCTCTTGGGTGGCCTCTGGGAATTTCCGGGCGGGAAACAGGAACCCGGAGAGGCCATCGAGG
CCACGGTGGTGCGCGAACTCCAAGAGGAGCTGGCGATCGAGGTGGAGGTCACGGAGCCCCTGATCAGCCTCGATCACGCC
TACAGCCACAAACGCTTGCGTTTTGAGGTGTTCCTCTGCCGCTGGATCAGCGGCGAGCCGCAAGCGTTGGCAAGTCAGCA
GGTGCGTTGGGTCCACCCCACTGGCTTGGCTGCCTTCCCGTTCCCAGCCGCCAATGCGCGGATCATTGCTGCCTTACTGC
AGCGCTTTGGCCACTCTGAGGAGAGCAGCAAGGTGGCCTGA

Upstream 100 bases:

>100_bases
TCATTGCCTCATTACGGCTCTAATCGAAGTCATGTTTCGCCTGTTTCAAATCAGTCACTAACTGTCAAATCAGCTGATTT
AATTAAGAGGTATTATTCGT

Downstream 100 bases:

>100_bases
TGGCCCAGGTGTTCTGCCTCGGTGAGGCCTTGATCGATCGTCTGCTCCCCTGGGGCGATGATCTAGGCCGAGATTGTTTG
GGTGGTGCGCCCGCCAATGG

Product: A/G-specific DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MIMRILPINSLLRSVNFAPCVTSYLQLSLLIWSEQFGRKAIPWKHANTSGLLDIYGIWIAEVMLQQTQLQVALPYWQRWM
QALPTVDALAAADEQQVLLLWQGLGYYSRARRLHQAAQQLQGQPWPQDLEAWLALPGIGRSTAGSILSSAFDRPFAILDG
NVKRVLARLTAFEHPPARHSAHFWSLSEQLLDRQRPRDFNQALMDLGATLCTPRQPDCPRCPWQSHCSAYAAGSPEQFPV
KESPKPLPLQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATVVRELQEELAIEVEVTEPLISLDHA
YSHKRLRFEVFLCRWISGEPQALASQQVRWVHPTGLAAFPFPAANARIIAALLQRFGHSEESSKVA

Sequences:

>Translated_386_residues
MIMRILPINSLLRSVNFAPCVTSYLQLSLLIWSEQFGRKAIPWKHANTSGLLDIYGIWIAEVMLQQTQLQVALPYWQRWM
QALPTVDALAAADEQQVLLLWQGLGYYSRARRLHQAAQQLQGQPWPQDLEAWLALPGIGRSTAGSILSSAFDRPFAILDG
NVKRVLARLTAFEHPPARHSAHFWSLSEQLLDRQRPRDFNQALMDLGATLCTPRQPDCPRCPWQSHCSAYAAGSPEQFPV
KESPKPLPLQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATVVRELQEELAIEVEVTEPLISLDHA
YSHKRLRFEVFLCRWISGEPQALASQQVRWVHPTGLAAFPFPAANARIIAALLQRFGHSEESSKVA
>Mature_386_residues
MIMRILPINSLLRSVNFAPCVTSYLQLSLLIWSEQFGRKAIPWKHANTSGLLDIYGIWIAEVMLQQTQLQVALPYWQRWM
QALPTVDALAAADEQQVLLLWQGLGYYSRARRLHQAAQQLQGQPWPQDLEAWLALPGIGRSTAGSILSSAFDRPFAILDG
NVKRVLARLTAFEHPPARHSAHFWSLSEQLLDRQRPRDFNQALMDLGATLCTPRQPDCPRCPWQSHCSAYAAGSPEQFPV
KESPKPLPLQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATVVRELQEELAIEVEVTEPLISLDHA
YSHKRLRFEVFLCRWISGEPQALASQQVRWVHPTGLAAFPFPAANARIIAALLQRFGHSEESSKVA

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=360, Percent_Identity=37.2222222222222, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298652, Length=360, Percent_Identity=37.2222222222222, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI190358497, Length=360, Percent_Identity=37.2222222222222, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI6912520, Length=360, Percent_Identity=37.2222222222222, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298650, Length=360, Percent_Identity=37.2222222222222, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298648, Length=360, Percent_Identity=37.2222222222222, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1789331, Length=309, Percent_Identity=42.3948220064725, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786288, Length=121, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788056, Length=120, Percent_Identity=31.6666666666667, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43177; Mature: 43177

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMRILPINSLLRSVNFAPCVTSYLQLSLLIWSEQFGRKAIPWKHANTSGLLDIYGIWIA
CEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
EVMLQQTQLQVALPYWQRWMQALPTVDALAAADEQQVLLLWQGLGYYSRARRLHQAAQQL
HHHHHHHHHHEECHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QGQPWPQDLEAWLALPGIGRSTAGSILSSAFDRPFAILDGNVKRVLARLTAFEHPPARHS
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCC
AHFWSLSEQLLDRQRPRDFNQALMDLGATLCTPRQPDCPRCPWQSHCSAYAAGSPEQFPV
HHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
KESPKPLPLQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATVVREL
CCCCCCCCEEEEEEEHEECCCHHHHHHHHHCCCHHCCHHCCCCCCCCCHHHHHHHHHHHH
QEELAIEVEVTEPLISLDHAYSHKRLRFEVFLCRWISGEPQALASQQVRWVHPTGLAAFP
HHHHEEEEEECCHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCEEECCCCCEECC
FPAANARIIAALLQRFGHSEESSKVA
CCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIMRILPINSLLRSVNFAPCVTSYLQLSLLIWSEQFGRKAIPWKHANTSGLLDIYGIWIA
CEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
EVMLQQTQLQVALPYWQRWMQALPTVDALAAADEQQVLLLWQGLGYYSRARRLHQAAQQL
HHHHHHHHHHEECHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QGQPWPQDLEAWLALPGIGRSTAGSILSSAFDRPFAILDGNVKRVLARLTAFEHPPARHS
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCC
AHFWSLSEQLLDRQRPRDFNQALMDLGATLCTPRQPDCPRCPWQSHCSAYAAGSPEQFPV
HHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
KESPKPLPLQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATVVREL
CCCCCCCCEEEEEEEHEECCCHHHHHHHHHCCCHHCCHHCCCCCCCCCHHHHHHHHHHHH
QEELAIEVEVTEPLISLDHAYSHKRLRFEVFLCRWISGEPQALASQQVRWVHPTGLAAFP
HHHHEEEEEECCHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCEEECCCCCEECC
FPAANARIIAALLQRFGHSEESSKVA
CCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]