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The map label for this gene is lrp [H]

Identifier: 147675687

GI number: 147675687

Start: 1607983

End: 1608477

Strand: Reverse

Name: lrp [H]

Synonym: VC0395_A1494

Alternate gene names: 147675687

Gene position: 1608477-1607983 (Counterclockwise)

Preceding gene: 147674493

Following gene: 147673704

Centisome position: 53.19

GC content: 42.83

Gene sequence:

>495_bases
ATGGTGGATAGTTATAAGAAGCCGTCTAAGGACTTAGACCGTATAGATCGCAATATATTGAATGAATTGCAAAAAGACGG
TCGAATTTCAAACGTAGAGTTATCAAAGCGTGTAGGGCTTTCACCTACACCCTGTCTTGAGCGTGTTCGTCGTCTAGAAC
GTCAAGGGTTTATTACTGGTTATACTGCATTATTGAACCCTCAGTATTTGGACGCCTCACTGTTGGTGTTTGTTGAAATT
ACGTTAAATCGTGGCGCGCCCGATGTATTTGAACAGTTTAATGCCGCGGTACAAAAGTTGGATGATATTCAAGAGTGTCA
CCTAGTTTCTGGTGATTTTGACTATCTGCTGAAAACCCGTGTATCGGATATGGGGGCTTATCGCCGTTTGTTAGGTGATA
CCTTGCTCCGTTTGCCGGGAGTCAATGACACTCGTACTTACGTGGTCATGGAAGAAGTGAAGCAAACCAACCAATTAGTG
ATTAAAACTCGCTAA

Upstream 100 bases:

>100_bases
ATTTGTGGCTAGTATAGTGACTAGTGTGAAAAATTTGATGCTAAATATTAAGAAGTTGTAGTATATTTTTTTGCAAGGAA
GTAATAAGGTGGAATAAAAA

Downstream 100 bases:

>100_bases
CTTAAAGCGAATGTTGGAGATCTTTCCACATTCTGACTTTCGTGAATTGGGTTTTTGCCCTTGATATGGTTAAATCTCCA
AACAAACCGAGCGGCGTTGG

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVDSYKKPSKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFITGYTALLNPQYLDASLLVFVEI
TLNRGAPDVFEQFNAAVQKLDDIQECHLVSGDFDYLLKTRVSDMGAYRRLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLV
IKTR

Sequences:

>Translated_164_residues
MVDSYKKPSKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFITGYTALLNPQYLDASLLVFVEI
TLNRGAPDVFEQFNAAVQKLDDIQECHLVSGDFDYLLKTRVSDMGAYRRLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLV
IKTR
>Mature_164_residues
MVDSYKKPSKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFITGYTALLNPQYLDASLLVFVEI
TLNRGAPDVFEQFNAAVQKLDDIQECHLVSGDFDYLLKTRVSDMGAYRRLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLV
IKTR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=164, Percent_Identity=91.4634146341463, Blast_Score=308, Evalue=1e-85,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=32.4503311258278, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790182, Length=140, Percent_Identity=26.4285714285714, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18790; Mature: 18790

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSYKKPSKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFITG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCHHH
YTALLNPQYLDASLLVFVEITLNRGAPDVFEQFNAAVQKLDDIQECHLVSGDFDYLLKTR
HHHHCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VSDMGAYRRLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLVIKTR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MVDSYKKPSKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFITG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCHHH
YTALLNPQYLDASLLVFVEITLNRGAPDVFEQFNAAVQKLDDIQECHLVSGDFDYLLKTR
HHHHCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VSDMGAYRRLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLVIKTR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]