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The map label for this gene is gcp

Identifier: 147675246

GI number: 147675246

Start: 45948

End: 46967

Strand: Direct

Name: gcp

Synonym: VC0395_A0049

Alternate gene names: 147675246

Gene position: 45948-46967 (Clockwise)

Preceding gene: 147675377

Following gene: 147673630

Centisome position: 1.52

GC content: 50.1

Gene sequence:

>1020_bases
ATGCGCATTATTGGTATTGAAACCTCTTGTGACGAAACGGGTATCGCGATTTACGATGACGAAAAAGGACTGCTGTCTCA
TAAGCTTTACAGTCAGGTAAAACTGCATGCCGATTATGGTGGTGTGGTGCCTGAGCTGGCTTCGCGTGATCATGTAAAAA
AAACCATCCCACTCATCAAAGCGGCGATGGCAGAGGCAAACGTGACGCCGCAAGATTTAGACGGTGTGGCTTTTACCGCA
GGCCCCGGTTTGGTTGGGGCGCTCTTGGTTGGCGCTACGATTGGGCGCAGTTTAGCGTACGCTTGGGATGTGCCAGCGGT
GCCGGTTCATCACATGGAAGGGCATCTTCTTGCTCCGATGCTGGAAGAGAATCCGCCGCCGTTTCCGTTTGTCGCTTTGC
TGGTATCGGGTGGTCACACCATGCTGGTGGAAGTGAAAAACATTGGTGAATACCGCATTTTAGGTGAGTCTATCGATGAT
GCGGCTGGCGAAGCCTTTGATAAAACGGCCAAATTGATGGGATTGGATTATCCAGGTGGCCCGTTATTGGCCAAGCTGGC
GGAAAAAGGGACTCCGGGACGCTTTAAATTTCCCCGTCCTATGACGGACAGACCGGGGCTCGATATGAGCTTTTCCGGTT
TAAAAACTTTTACTGCCAATACCATTGCTGCAAATGGCGACGATGAACAGACCCGTGCGGATATTGCTTACGCCTTCCAA
GAGGCCGTGTGTGACACTTTAGTCATTAAATGTAAACGCGCATTGGAGGAGACAGGACTTAAGCGTGTGGTGATTGCGGG
TGGTGTGAGTGCCAACAAGCAGTTGCGTGCTGATTTGGAAAAACTCGCGAAAAAAATCGGTGGCGAAGTGTATTACCCAC
GTACTGAATTTTGTACCGATAACGGAGCGATGATCGCTTATGCGGGCATGCAACGTTTGAAAAATGGTGATGTGTGTGAA
CTTGGCTTGCAAGCTCGCCCGCGTTGGCCGATTGATCAGTTAACGTCAATTCAGAAATAA

Upstream 100 bases:

>100_bases
CACTTTGTCGCTTACATTCTGGACAAGGTTTGTTTGTCGCGCCAAGGCGAGGTAACATGACGTCATATTTGATTTTAGAT
GGCAGCGTGCTGAGAAAACT

Downstream 100 bases:

>100_bases
GTACGACGAAATGGTATTGAAACGGTCGCGCTAGTGGCCGTTTTTTCTAAACAAAAGAATGAATTAGATAATGCTGAATT
TCTGCTCAGAGTTGTCTGCT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRIIGIETSCDETGIAIYDDEKGLLSHKLYSQVKLHADYGGVVPELASRDHVKKTIPLIKAAMAEANVTPQDLDGVAFTA
GPGLVGALLVGATIGRSLAYAWDVPAVPVHHMEGHLLAPMLEENPPPFPFVALLVSGGHTMLVEVKNIGEYRILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLAKLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFQ
EAVCDTLVIKCKRALEETGLKRVVIAGGVSANKQLRADLEKLAKKIGGEVYYPRTEFCTDNGAMIAYAGMQRLKNGDVCE
LGLQARPRWPIDQLTSIQK

Sequences:

>Translated_339_residues
MRIIGIETSCDETGIAIYDDEKGLLSHKLYSQVKLHADYGGVVPELASRDHVKKTIPLIKAAMAEANVTPQDLDGVAFTA
GPGLVGALLVGATIGRSLAYAWDVPAVPVHHMEGHLLAPMLEENPPPFPFVALLVSGGHTMLVEVKNIGEYRILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLAKLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFQ
EAVCDTLVIKCKRALEETGLKRVVIAGGVSANKQLRADLEKLAKKIGGEVYYPRTEFCTDNGAMIAYAGMQRLKNGDVCE
LGLQARPRWPIDQLTSIQK
>Mature_339_residues
MRIIGIETSCDETGIAIYDDEKGLLSHKLYSQVKLHADYGGVVPELASRDHVKKTIPLIKAAMAEANVTPQDLDGVAFTA
GPGLVGALLVGATIGRSLAYAWDVPAVPVHHMEGHLLAPMLEENPPPFPFVALLVSGGHTMLVEVKNIGEYRILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLAKLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFQ
EAVCDTLVIKCKRALEETGLKRVVIAGGVSANKQLRADLEKLAKKIGGEVYYPRTEFCTDNGAMIAYAGMQRLKNGDVCE
LGLQARPRWPIDQLTSIQK

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=357, Percent_Identity=32.4929971988796, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI8923380, Length=320, Percent_Identity=30.625, Blast_Score=144, Evalue=8e-35,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=76.3473053892216, Blast_Score=544, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17557464, Length=330, Percent_Identity=30.6060606060606, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71995670, Length=350, Percent_Identity=31.7142857142857, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320099, Length=371, Percent_Identity=32.0754716981132, Blast_Score=175, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6322891, Length=350, Percent_Identity=30.2857142857143, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20129063, Length=338, Percent_Identity=33.7278106508876, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357207, Length=331, Percent_Identity=31.1178247734139, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_VIBC3 (A5F9E8)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F9E8
- SMR:   A5F9E8
- STRING:   A5F9E8
- MEROPS:   M22.001
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0049
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   VCHO345073:VC0395_A0049-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36507; Mature: 36507

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIGIETSCDETGIAIYDDEKGLLSHKLYSQVKLHADYGGVVPELASRDHVKKTIPLIK
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHEEEECCCCCCCHHHHCHHHHHHHHHHHH
AAMAEANVTPQDLDGVAFTAGPGLVGALLVGATIGRSLAYAWDVPAVPVHHMEGHLLAPM
HHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCHHCCCCCEECHH
LEENPPPFPFVALLVSGGHTMLVEVKNIGEYRILGESIDDAAGEAFDKTAKLMGLDYPGG
HHCCCCCCCEEEHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHEECCCCCC
PLLAKLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFQ
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCEEECCEEECCCCCHHHHHHHHHHHH
EAVCDTLVIKCKRALEETGLKRVVIAGGVSANKQLRADLEKLAKKIGGEVYYPRTEFCTD
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCHHEECC
NGAMIAYAGMQRLKNGDVCELGLQARPRWPIDQLTSIQK
CCCEEEEHHHHHCCCCCEEEECCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MRIIGIETSCDETGIAIYDDEKGLLSHKLYSQVKLHADYGGVVPELASRDHVKKTIPLIK
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHEEEECCCCCCCHHHHCHHHHHHHHHHHH
AAMAEANVTPQDLDGVAFTAGPGLVGALLVGATIGRSLAYAWDVPAVPVHHMEGHLLAPM
HHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCHHCCCCCEECHH
LEENPPPFPFVALLVSGGHTMLVEVKNIGEYRILGESIDDAAGEAFDKTAKLMGLDYPGG
HHCCCCCCCEEEHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHEECCCCCC
PLLAKLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFQ
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCEEECCEEECCCCCHHHHHHHHHHHH
EAVCDTLVIKCKRALEETGLKRVVIAGGVSANKQLRADLEKLAKKIGGEVYYPRTEFCTD
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCHHEECC
NGAMIAYAGMQRLKNGDVCELGLQARPRWPIDQLTSIQK
CCCEEEEHHHHHCCCCCEEEECCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA