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The map label for this gene is xseA

Identifier: 147675003

GI number: 147675003

Start: 309183

End: 310523

Strand: Reverse

Name: xseA

Synonym: VC0395_A0294

Alternate gene names: 147675003

Gene position: 310523-309183 (Counterclockwise)

Preceding gene: 147673711

Following gene: 147673841

Centisome position: 10.27

GC content: 49.66

Gene sequence:

>1341_bases
TTGTCTTCTTCTCTCGCCAATCGAAATATCTACACCGTTTCCCGTTTAAATTCTGAAGTTCGTTTATTACTGGAAAATGA
AATGGGGATCGTCTGGTTGGTGGGTGAAATTTCCAACTTCTCCGCTCCCGTCTCTGGTCACTGGTATCTCACTTTAAAAG
ACAGCCAAGCGCAGGTTAAATGCGCTATGTTCAAAGGCAATAACCGTCTGGTGAATTTCAAACCGCAAAATGGTCAGCAA
GTATTAGTTAAAGCTCGACTTTCTCTTTACGAACCGCGCGGTGACTACCAAATTATTCTTGAAAGCATGCAACCGGAAGG
GGATGGCCGTCTGCAGCAGCAGTTTGAACAACTGAAGATGCAGCTCGCCGCCGAAGGTTTGTTTGCTCAGACACGTAAAA
AACCATTGCCGGAAAATCCACGCTGCGTGGGGATTATCACCTCACGGACTGGCGCGGCTTTGCACGATATTTTGCACGTG
CTTAAGCGCCGTGACCCGAATCTGCCTGTAGTGATCTACCCCACTCTCGTACAAGGTGAAGAGGCAGCTATTCAAATCGC
CCAAGCGATTGGTCGTGCGAATACACGCGCCGAGTGCGATGTGTTGATAGTAGGTCGTGGTGGTGGCTCTTTGGAAGATT
TGTGGTGTTTTAACCATGAAATCGTGGCACGTACTATCGCTGCGAGTGAAATCCCAATTATCAGTGCTGTAGGCCATGAA
ATCGATGTGACGATCGCTGACTTTGTCGCCGATGTGCGTGCCCCTACCCCATCAGCAGCGGCGGAATTGGTCAGCCGTGA
TCATCGCCATAAACAGCAAGCACTCCATCAATGGCAAGCCAAACTGGCTAGCACCATGCGCCATTATTTGGCGCAGCAAG
AGACGCAATTTGCCCGTTTACAGCACAAGCTTGATAAACAGCATCCTCAAGCTCGTTTAGAGCGCCAGCAGCAGCAACTT
GATGAGCTCAGCCTGCGTCTTGAGCAAAAGATGCAGCAACGTCTGGCAACTCAGCAGCAACGCTGGGATCGCTTAAGCCA
TAAGATCGAGCTCCATTCGCCCATTCACTTGATCCGCCAGCAGCGTTTTAATCTGATCCAGCAAGAGCAGCGAATAAATC
AGTCGATCCAACGCTATTTGATCCAATCACGCCATCAACTCGCTTTGTTGAGTGAAAAGTTGGATGCGGTCAGCCCTCTT
GCAGCCTTAGCCCGTGGCTATTCGGTGACACGTACCACACAAGGTGAGTTAGTGCGCCAAAGCGCGCAAGTGAAACCGGG
TGACACTTTAGTCACCCAGTTAATGGATGGTGAGATTCTCTCTACTGTGAATTCCCGTTAA

Upstream 100 bases:

>100_bases
ATCGGTTGACTACACATTTTTTCATTTTTTATTTGCATTTCACCCCTTGATATGTATTATATTGCGGCTAATTTCCATAC
CCACGTCTGAGGAATCAGCG

Downstream 100 bases:

>100_bases
GCGGTTGGAAGACAAAACGGATTTTGGATTTCGATTTCAGCTCATTACACTGATTACAGAAATAATTCGCCGCACCACAA
GCCTGTAGCTTTTCTAATTC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVKCAMFKGNNRLVNFKPQNGQQ
VLVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKMQLAAEGLFAQTRKKPLPENPRCVGIITSRTGAALHDILHV
LKRRDPNLPVVIYPTLVQGEEAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTIAASEIPIISAVGHE
IDVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARLQHKLDKQHPQARLERQQQQL
DELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQQRFNLIQQEQRINQSIQRYLIQSRHQLALLSEKLDAVSPL
AALARGYSVTRTTQGELVRQSAQVKPGDTLVTQLMDGEILSTVNSR

Sequences:

>Translated_446_residues
MSSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVKCAMFKGNNRLVNFKPQNGQQ
VLVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKMQLAAEGLFAQTRKKPLPENPRCVGIITSRTGAALHDILHV
LKRRDPNLPVVIYPTLVQGEEAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTIAASEIPIISAVGHE
IDVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARLQHKLDKQHPQARLERQQQQL
DELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQQRFNLIQQEQRINQSIQRYLIQSRHQLALLSEKLDAVSPL
AALARGYSVTRTTQGELVRQSAQVKPGDTLVTQLMDGEILSTVNSR
>Mature_445_residues
SSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVKCAMFKGNNRLVNFKPQNGQQV
LVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKMQLAAEGLFAQTRKKPLPENPRCVGIITSRTGAALHDILHVL
KRRDPNLPVVIYPTLVQGEEAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTIAASEIPIISAVGHEI
DVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARLQHKLDKQHPQARLERQQQQLD
ELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQQRFNLIQQEQRINQSIQRYLIQSRHQLALLSEKLDAVSPLA
ALARGYSVTRTTQGELVRQSAQVKPGDTLVTQLMDGEILSTVNSR

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=436, Percent_Identity=56.651376146789, Blast_Score=488, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_VIBC3 (A5F3E9)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- STRING:   A5F3E9
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0294
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- BioCyc:   VCHO345073:VC0395_A0294-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50514; Mature: 50382

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVK
CCCCCCCCCEEEHHHCCCHHEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEECCCCEEE
CAMFKGNNRLVNFKPQNGQQVLVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKM
EEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
QLAAEGLFAQTRKKPLPENPRCVGIITSRTGAALHDILHVLKRRDPNLPVVIYPTLVQGE
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECEECCH
EAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTIAASEIPIISAVGHE
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCEEECCCCE
IDVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARL
EEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHKLDKQHPQARLERQQQQLDELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHH
QRFNLIQQEQRINQSIQRYLIQSRHQLALLSEKLDAVSPLAALARGYSVTRTTQGELVRQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHH
SAQVKPGDTLVTQLMDGEILSTVNSR
HCCCCCCHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
SSSLANRNIYTVSRLNSEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSQAQVK
CCCCCCCCEEEHHHCCCHHEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEECCCCEEE
CAMFKGNNRLVNFKPQNGQQVLVKARLSLYEPRGDYQIILESMQPEGDGRLQQQFEQLKM
EEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
QLAAEGLFAQTRKKPLPENPRCVGIITSRTGAALHDILHVLKRRDPNLPVVIYPTLVQGE
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECEECCH
EAAIQIAQAIGRANTRAECDVLIVGRGGGSLEDLWCFNHEIVARTIAASEIPIISAVGHE
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCEEECCCCE
IDVTIADFVADVRAPTPSAAAELVSRDHRHKQQALHQWQAKLASTMRHYLAQQETQFARL
EEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHKLDKQHPQARLERQQQQLDELSLRLEQKMQQRLATQQQRWDRLSHKIELHSPIHLIRQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHH
QRFNLIQQEQRINQSIQRYLIQSRHQLALLSEKLDAVSPLAALARGYSVTRTTQGELVRQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHH
SAQVKPGDTLVTQLMDGEILSTVNSR
HCCCCCCHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA