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The map label for this gene is lolE [H]

Identifier: 147674975

GI number: 147674975

Start: 1579659

End: 1580903

Strand: Reverse

Name: lolE [H]

Synonym: VC0395_A1472

Alternate gene names: 147674975

Gene position: 1580903-1579659 (Counterclockwise)

Preceding gene: 147675470

Following gene: 147673615

Centisome position: 52.28

GC content: 51.08

Gene sequence:

>1245_bases
GTGTTTTCCTCTCTCGCTCTGTTTATTGGCGGACGCTTTAGTCGCGCTAAACAACGTAACAAGATGGTGTCGTTTATTTC
GTTGTCGTCCACGATTGGGATTGCGGTTGGTGTGGCGGTGATCATCATCGGCCTTTCGGCGATGAATGGTTTTGAGCGTG
AATTGCAAACCCGTGTTCTATCCGTTATCCCACATGGGGAATTTGAGGGCGTGCGCGGACCTGTCGAACGCTGGCCTGAT
TTAATGGCGCAAGCCGCGCGTCACCCACAAATTGTTGCGGCAGCGCCGTATGTGAAGATCACAGCACTTGCCGAAAGTGG
CACTCAGCTTAAAGCGATTGAAGTGCGCGGTGTGGATCCGCAGCGTGAGCAAGCCGTATCTCGCTTGTCGCAGTTTATTA
CCGCGCAGGCATGGCAAGACTTTCGCCCCGGTCAGCAGCAGGTGATTTTAGGCCAAGGTGTTGCGGAGAAATTAGGCGTG
CAGGTTGGTGATTTCATTACCTTGATGATCCCAAGTGCCAACAGTGGTGACAAGGTGCAAGCACCGAAGCGGGTCCGTGT
GAAAGTCAGCGGCTTATTGGCACTGAACGGGCAGATTGATCACAGCTTAGCGCTACTGCCGCTAGAAGATGCCCAAGCTT
ATGCTCACTTAGGTAGTGGTGTTACCGGTATCTCTGTTAAGGTGGCCGATGTGCTGCAAGCAACGCAGATCGTACGTGAT
GTGGGTAATCAACTGAACGAATACGTCTATCTGCATAGTTGGCAGCAAAAGTACGGCTTTTTGTATCGCGATATTCAGTT
GGTGCGCACCATTATGTATTTAGTAATGGTACTGGTGATTGGGGTCGCGAGCTTTAACATCGTCTCGACTCTGATGATGG
CGGTAAAAGATCGCGCAGGCGAAATCGCTATATTGCGCACTATGGGCGCGACCGATGGCTTGATCAAACGTATTTTCGTC
TGGCAAGGCGTGTTTTCTGGGGTTCTGGGTAGTGTGGTCGGCAGTGTATTGGGTATGGTTGTCGCCTTTAATTTAACGCC
TTTGATCAAAGGGTTAGAGCATCTGATCGGACATCAGTTTTTATCCGGTGATATCTATTTCGTTGATTTTCTTCCTTCAC
AGGTGGAGTGGGCAGATGTAGTGCTGGTTTCAGGGACGGCGATTGTGCTGAGTTTGCTGGCGACTTGGTACCCCGCGCGG
CGCGCAAGCCGACTCAATCCTGCGCAAGTGTTGAGTAGTAAATAA

Upstream 100 bases:

>100_bases
CGCCTTTTTGGTGGTCACTCACGATGGCGAGTTGGCGGCGAAAATGGATCGTCACATGCACATGAAAGATGGGCTGCTAA
CCGATATCACGGGGGCTTAA

Downstream 100 bases:

>100_bases
CATCAAACAAAAAAGGACCTTCGGGTCCTTTTTTCATGCTGAGTAAACAGAGTTTGCATTGTTTAAGCTGCGCTTGTTCG
CAACTCTCTTGCAATCGTGA

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MFSSLALFIGGRFSRAKQRNKMVSFISLSSTIGIAVGVAVIIIGLSAMNGFERELQTRVLSVIPHGEFEGVRGPVERWPD
LMAQAARHPQIVAAAPYVKITALAESGTQLKAIEVRGVDPQREQAVSRLSQFITAQAWQDFRPGQQQVILGQGVAEKLGV
QVGDFITLMIPSANSGDKVQAPKRVRVKVSGLLALNGQIDHSLALLPLEDAQAYAHLGSGVTGISVKVADVLQATQIVRD
VGNQLNEYVYLHSWQQKYGFLYRDIQLVRTIMYLVMVLVIGVASFNIVSTLMMAVKDRAGEIAILRTMGATDGLIKRIFV
WQGVFSGVLGSVVGSVLGMVVAFNLTPLIKGLEHLIGHQFLSGDIYFVDFLPSQVEWADVVLVSGTAIVLSLLATWYPAR
RASRLNPAQVLSSK

Sequences:

>Translated_414_residues
MFSSLALFIGGRFSRAKQRNKMVSFISLSSTIGIAVGVAVIIIGLSAMNGFERELQTRVLSVIPHGEFEGVRGPVERWPD
LMAQAARHPQIVAAAPYVKITALAESGTQLKAIEVRGVDPQREQAVSRLSQFITAQAWQDFRPGQQQVILGQGVAEKLGV
QVGDFITLMIPSANSGDKVQAPKRVRVKVSGLLALNGQIDHSLALLPLEDAQAYAHLGSGVTGISVKVADVLQATQIVRD
VGNQLNEYVYLHSWQQKYGFLYRDIQLVRTIMYLVMVLVIGVASFNIVSTLMMAVKDRAGEIAILRTMGATDGLIKRIFV
WQGVFSGVLGSVVGSVLGMVVAFNLTPLIKGLEHLIGHQFLSGDIYFVDFLPSQVEWADVVLVSGTAIVLSLLATWYPAR
RASRLNPAQVLSSK
>Mature_414_residues
MFSSLALFIGGRFSRAKQRNKMVSFISLSSTIGIAVGVAVIIIGLSAMNGFERELQTRVLSVIPHGEFEGVRGPVERWPD
LMAQAARHPQIVAAAPYVKITALAESGTQLKAIEVRGVDPQREQAVSRLSQFITAQAWQDFRPGQQQVILGQGVAEKLGV
QVGDFITLMIPSANSGDKVQAPKRVRVKVSGLLALNGQIDHSLALLPLEDAQAYAHLGSGVTGISVKVADVLQATQIVRD
VGNQLNEYVYLHSWQQKYGFLYRDIQLVRTIMYLVMVLVIGVASFNIVSTLMMAVKDRAGEIAILRTMGATDGLIKRIFV
WQGVFSGVLGSVVGSVLGMVVAFNLTPLIKGLEHLIGHQFLSGDIYFVDFLPSQVEWADVVLVSGTAIVLSLLATWYPAR
RASRLNPAQVLSSK

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=57.0048309178744, Blast_Score=483, Evalue=1e-138,
Organism=Escherichia coli, GI1787360, Length=414, Percent_Identity=30.4347826086957, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44947; Mature: 44947

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSLALFIGGRFSRAKQRNKMVSFISLSSTIGIAVGVAVIIIGLSAMNGFERELQTRVL
CCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SVIPHGEFEGVRGPVERWPDLMAQAARHPQIVAAAPYVKITALAESGTQLKAIEVRGVDP
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCEEEEEEEECCCH
QREQAVSRLSQFITAQAWQDFRPGQQQVILGQGVAEKLGVQVGDFITLMIPSANSGDKVQ
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCCCCCCEEEEEEECCCCCCCCC
APKRVRVKVSGLLALNGQIDHSLALLPLEDAQAYAHLGSGVTGISVKVADVLQATQIVRD
CCCEEEEEEEEEEEECCCCCCCEEEEECHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHH
VGNQLNEYVYLHSWQQKYGFLYRDIQLVRTIMYLVMVLVIGVASFNIVSTLMMAVKDRAG
HHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EIAILRTMGATDGLIKRIFVWQGVFSGVLGSVVGSVLGMVVAFNLTPLIKGLEHLIGHQF
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDIYFVDFLPSQVEWADVVLVSGTAIVLSLLATWYPARRASRLNPAQVLSSK
HCCCEEEEECCCCCCCHHHEEEECCHHHHHHHHHHHCCHHHCCCCCHHHHHCCC
>Mature Secondary Structure
MFSSLALFIGGRFSRAKQRNKMVSFISLSSTIGIAVGVAVIIIGLSAMNGFERELQTRVL
CCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SVIPHGEFEGVRGPVERWPDLMAQAARHPQIVAAAPYVKITALAESGTQLKAIEVRGVDP
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCEEEEEEEECCCH
QREQAVSRLSQFITAQAWQDFRPGQQQVILGQGVAEKLGVQVGDFITLMIPSANSGDKVQ
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCCCCCCEEEEEEECCCCCCCCC
APKRVRVKVSGLLALNGQIDHSLALLPLEDAQAYAHLGSGVTGISVKVADVLQATQIVRD
CCCEEEEEEEEEEEECCCCCCCEEEEECHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHH
VGNQLNEYVYLHSWQQKYGFLYRDIQLVRTIMYLVMVLVIGVASFNIVSTLMMAVKDRAG
HHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EIAILRTMGATDGLIKRIFVWQGVFSGVLGSVVGSVLGMVVAFNLTPLIKGLEHLIGHQF
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDIYFVDFLPSQVEWADVVLVSGTAIVLSLLATWYPARRASRLNPAQVLSSK
HCCCEEEEECCCCCCCHHHEEEECCHHHHHHHHHHHCCHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]