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The map label for this gene is ffh [H]

Identifier: 147674906

GI number: 147674906

Start: 85450

End: 86835

Strand: Direct

Name: ffh [H]

Synonym: VC0395_A0094

Alternate gene names: 147674906

Gene position: 85450-86835 (Clockwise)

Preceding gene: 147674316

Following gene: 147674693

Centisome position: 2.83

GC content: 49.93

Gene sequence:

>1386_bases
ATGTTTGAGAATTTAACCGATCGATTGTCCAAAACGCTGAAAAATATCAGCGGCAAAGGTCGTCTTACTGAAGACAACAT
TAAAGATACCCTGCGCGAAGTGCGCATGGCGCTGTTAGAGGCGGACGTTGCGCTGCCTGTCGTTCGTGATTTCGTCAATC
GCGTTAAAGAAGGCGCGGTGGGGGTCGAGGTTTCCAAATCTCTGACTCCGGGTCAAGAGTTCATCAAAATCGTCCGCCAG
CAACTTGAAGCTGTGATGGGCGAATCCAACGAAGCGTTGAATCTTGCCGCTCAGCCTCCAGCGGTTATTTTGATGGCTGG
TTTGCAAGGTGCGGGTAAAACCACATCCGTAGGCAAACTCTCTAAGCTCCTAAAAGAGCGTGATAAGAAGAAAGTGTTGG
TGGTTTCCGCCGACGTGTATCGCCCAGCGGCGATCAAGCAGCTCGAAACATTAGCCAATGATTTAGGCGTTGATTTCTTC
CCGTCCACACCGGATCAAAAACCGATTGATATCGCTAACGCTGCAATTGATCACGCTAAGAAGAAATTCTACGACGTACT
GATTGTCGATACCGCAGGTCGTTTGGCGATTGATGAGCAGATGATGGCGGAGATCCAAGCGCTGCATAAAGCGATCAATC
CGGTTGAAACCCTGTTCGTGGTCGATGCCATGACGGGTCAAGATGCCGCCAATACCGCGAAAGCGTTTGGTGATGCATTG
CCACTGACCGGGGTGATTCTAACCAAGGTCGATGGTGATGCCCGTGGCGGTGCGGCGTTGTCGGTACGCCATATTACCGG
TAAACCGATTAAATTTATCGGTGTCGGCGAGAAAACCGATGCCTTAGAGCCTTTCCATCCGGATCGTATTGCTTCACGCA
TTCTTGGTATGGGCGATGTACTGTCGCTGATCGAAGATCTGCAGCGCAATGTTGACCAAGAGAAAGCCGAAAAACTCGCG
AAAAAATTCAAAGAGAAGAAAGGCTTTGATTTAGAAGACTTTCGTGAGCAGTTAGGTCAGATGAAAAACATGGGCGGCAT
GATGGGGATGCTCGATAAACTGCCCGGAATGTCTCAACTGCCTGCGGATATGAAAGACAAAGTGGATGATCGCGTTTTCA
AACAGATGGAAGCCATCATCAACTCAATGACCATGAAAGAGCGTCAAAACCCAGACCTCATCAAAGGCTCACGCAAAAAG
CGGATTGCTGCGGGTTCCGGTACCCAAGTGCAAGACGTAAACCGCCTGCTCAAGCAATTTACCCAGATGCAGAAGATGAT
GAAGAAAATGCAACAAGGTGGCATGAAAGGCATGATGCGTAACATGCAAGGCCTGATGGGCGGCGGTGGCCGTGGTGGTT
TCGGCGGCGGTTTCTTCGGTCGTTAA

Upstream 100 bases:

>100_bases
ATGATATTCGTGAATGTGAGCATTGGGTAACGGGTATGCCTGTCCGTTTGTCTAAGGTATACTCACGCCAATTTATCGCC
GCTTAGCGAAGAGAAAAAAG

Downstream 100 bases:

>100_bases
TTCACTCGCACGCAACCGCTTGAGTGTTCAGTGAACTTTCCAATTTGTTAACTGAATCACGGTAATTTGTAGCGCTTTAA
GCTGGCGAAAAAGTAGCTAA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MFENLTDRLSKTLKNISGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFVNRVKEGAVGVEVSKSLTPGQEFIKIVRQ
QLEAVMGESNEALNLAAQPPAVILMAGLQGAGKTTSVGKLSKLLKERDKKKVLVVSADVYRPAAIKQLETLANDLGVDFF
PSTPDQKPIDIANAAIDHAKKKFYDVLIVDTAGRLAIDEQMMAEIQALHKAINPVETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRHITGKPIKFIGVGEKTDALEPFHPDRIASRILGMGDVLSLIEDLQRNVDQEKAEKLA
KKFKEKKGFDLEDFREQLGQMKNMGGMMGMLDKLPGMSQLPADMKDKVDDRVFKQMEAIINSMTMKERQNPDLIKGSRKK
RIAAGSGTQVQDVNRLLKQFTQMQKMMKKMQQGGMKGMMRNMQGLMGGGGRGGFGGGFFGR

Sequences:

>Translated_461_residues
MFENLTDRLSKTLKNISGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFVNRVKEGAVGVEVSKSLTPGQEFIKIVRQ
QLEAVMGESNEALNLAAQPPAVILMAGLQGAGKTTSVGKLSKLLKERDKKKVLVVSADVYRPAAIKQLETLANDLGVDFF
PSTPDQKPIDIANAAIDHAKKKFYDVLIVDTAGRLAIDEQMMAEIQALHKAINPVETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRHITGKPIKFIGVGEKTDALEPFHPDRIASRILGMGDVLSLIEDLQRNVDQEKAEKLA
KKFKEKKGFDLEDFREQLGQMKNMGGMMGMLDKLPGMSQLPADMKDKVDDRVFKQMEAIINSMTMKERQNPDLIKGSRKK
RIAAGSGTQVQDVNRLLKQFTQMQKMMKKMQQGGMKGMMRNMQGLMGGGGRGGFGGGFFGR
>Mature_461_residues
MFENLTDRLSKTLKNISGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFVNRVKEGAVGVEVSKSLTPGQEFIKIVRQ
QLEAVMGESNEALNLAAQPPAVILMAGLQGAGKTTSVGKLSKLLKERDKKKVLVVSADVYRPAAIKQLETLANDLGVDFF
PSTPDQKPIDIANAAIDHAKKKFYDVLIVDTAGRLAIDEQMMAEIQALHKAINPVETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRHITGKPIKFIGVGEKTDALEPFHPDRIASRILGMGDVLSLIEDLQRNVDQEKAEKLA
KKFKEKKGFDLEDFREQLGQMKNMGGMMGMLDKLPGMSQLPADMKDKVDDRVFKQMEAIINSMTMKERQNPDLIKGSRKK
RIAAGSGTQVQDVNRLLKQFTQMQKMMKKMQQGGMKGMMRNMQGLMGGGGRGGFGGGFFGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=446, Percent_Identity=32.2869955156951, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI226371618, Length=348, Percent_Identity=35.0574712643678, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=39.5833333333333, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=26.5625, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI295424842, Length=320, Percent_Identity=26.5625, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=76.7699115044248, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.5849056603774, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.1479820627803, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI193206261, Length=201, Percent_Identity=35.8208955223881, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=431, Percent_Identity=32.7146171693735, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI17647949, Length=455, Percent_Identity=31.6483516483516, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=30.4545454545455, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50374; Mature: 50374

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSKTLKNISGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFVNRVKEGAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVEVSKSLTPGQEFIKIVRQQLEAVMGESNEALNLAAQPPAVILMAGLQGAGKTTSVGKL
CCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCCCHHHHH
SKLLKERDKKKVLVVSADVYRPAAIKQLETLANDLGVDFFPSTPDQKPIDIANAAIDHAK
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
KKFYDVLIVDTAGRLAIDEQMMAEIQALHKAINPVETLFVVDAMTGQDAANTAKAFGDAL
HHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRHITGKPIKFIGVGEKTDALEPFHPDRIASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLQRNVDQEKAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMLDKLPGMSQL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PADMKDKVDDRVFKQMEAIINSMTMKERQNPDLIKGSRKKRIAAGSGTQVQDVNRLLKQF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHEEECCCCCCHHHHHHHHHHH
TQMQKMMKKMQQGGMKGMMRNMQGLMGGGGRGGFGGGFFGR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSKTLKNISGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFVNRVKEGAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVEVSKSLTPGQEFIKIVRQQLEAVMGESNEALNLAAQPPAVILMAGLQGAGKTTSVGKL
CCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCCCHHHHH
SKLLKERDKKKVLVVSADVYRPAAIKQLETLANDLGVDFFPSTPDQKPIDIANAAIDHAK
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
KKFYDVLIVDTAGRLAIDEQMMAEIQALHKAINPVETLFVVDAMTGQDAANTAKAFGDAL
HHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRHITGKPIKFIGVGEKTDALEPFHPDRIASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLQRNVDQEKAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMLDKLPGMSQL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PADMKDKVDDRVFKQMEAIINSMTMKERQNPDLIKGSRKKRIAAGSGTQVQDVNRLLKQF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHEEECCCCCCHHHHHHHHHHH
TQMQKMMKKMQQGGMKGMMRNMQGLMGGGGRGGFGGGFFGR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]