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The map label for this gene is ribB/A [H]

Identifier: 147674884

GI number: 147674884

Start: 1976856

End: 1977965

Strand: Reverse

Name: ribB/A [H]

Synonym: VC0395_A1859

Alternate gene names: 147674884

Gene position: 1977965-1976856 (Counterclockwise)

Preceding gene: 147673055

Following gene: 147675653

Centisome position: 65.41

GC content: 51.44

Gene sequence:

>1110_bases
ATGCCAATTAGCACCCCACAAGAGATCATTGAAGACATTCGTCAAGGCAAAATGGTCATCCTGATGGATGATGAAGATCG
TGAAAATGAAGGCGATCTGATCATGGCGGCTGAGCACATTACGCCAGCAGCGATCAATTTTATGGCAACCCATGGTCGCG
GACTCATCTGTTTAACGCTCACGAAAGAGCGTTGTCGCCGTCTGGGTTTAAATCCCATGGTACAAGATAATAATGCCCAG
TACACCACCAATTTCACCGTTTCGATTGAAGCTGCCGAAGGCGTGACCACCGGTATTTCAGCGGCGGATCGCGCGCGCAC
AGTACAAGCGGCAGTGGCAAAAGAAGCGAAAGCGGCCGATTTGGTTCAGCCGGGGCATATTTTCCCGTTGGCTGCACAAG
ATGGCGGAGTATTAACGCGCGCTGGGCACACAGAAGCTGGGTGTGATTTGGCACGCTTGGCAGGTTTAGAGCCCGCGTCG
GTGATTGTGGAAATTCTTAATGATGACGGCACCATGGCGCGTCGTCCGGACTTAGAAGTGTTCGCTGAAAAACACGGCTT
AAAGCTGGGTACGATTGCAGACTTGATTGAGTACCGCAACCACACCGAAACCACCATTGAGCGTGTCGCGCAGTGTAAAC
TGCCAACCGAATATGGTGAGTTTGAGCTGGTGACTTACCGCGACATCATCGATAAGCAAATCCACTTTGCTCTGCGTAAA
GGCGATATTACTAGTGCGCCAACTCTTGTGCGTGTGCATCTGCAAGATACTTTTACCGATCTGCTGCACAGCAACCGTGC
GGCAGAGCGCAGTTGGCCACTTGCGACAGCAATGCAGCGTATTGGGCAAGAAGGCGGGGTGTTGGTGATCCTGGGTCATG
AAGAATCGAGTGAGCTCTTGCTACACCGAGTGAAAATGTTTGAGCTGCAAGATAAAGGCGAAGCCCCTGCGATGGCCAAA
AAACAAGGCACTTCACGCCGGGTCGGGGTTGGCTCGCAAATCCTTGCTGATCTTGGAGTGAAAGAGATGCGTCTGCTCTC
TTCACCAAACAAAAAGTACCACGCATTGGGTGGTTTTGGTCTCAATGTGGTCGAATACGTCTGCGAATAA

Upstream 100 bases:

>100_bases
GAGAGTGAACCTCAATCGCGTCTGACCATGGCATTTTTGCAACAAAACGGTTTTGCTTAACCTCAGCTCTCAGAGGTTTC
ATAACAATAGGACTGACATC

Downstream 100 bases:

>100_bases
TCGCTATTCCCTTGCTACTTGAAGTGGCAGTGGAGTGAGCGACCTTCATTCCCCCAAGCATAGAACCTACCTATACTGGG
GGATGAACTTACTGTCCGCC

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MPISTPQEIIEDIRQGKMVILMDDEDRENEGDLIMAAEHITPAAINFMATHGRGLICLTLTKERCRRLGLNPMVQDNNAQ
YTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGLEPAS
VIVEILNDDGTMARRPDLEVFAEKHGLKLGTIADLIEYRNHTETTIERVAQCKLPTEYGEFELVTYRDIIDKQIHFALRK
GDITSAPTLVRVHLQDTFTDLLHSNRAAERSWPLATAMQRIGQEGGVLVILGHEESSELLLHRVKMFELQDKGEAPAMAK
KQGTSRRVGVGSQILADLGVKEMRLLSSPNKKYHALGGFGLNVVEYVCE

Sequences:

>Translated_369_residues
MPISTPQEIIEDIRQGKMVILMDDEDRENEGDLIMAAEHITPAAINFMATHGRGLICLTLTKERCRRLGLNPMVQDNNAQ
YTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGLEPAS
VIVEILNDDGTMARRPDLEVFAEKHGLKLGTIADLIEYRNHTETTIERVAQCKLPTEYGEFELVTYRDIIDKQIHFALRK
GDITSAPTLVRVHLQDTFTDLLHSNRAAERSWPLATAMQRIGQEGGVLVILGHEESSELLLHRVKMFELQDKGEAPAMAK
KQGTSRRVGVGSQILADLGVKEMRLLSSPNKKYHALGGFGLNVVEYVCE
>Mature_368_residues
PISTPQEIIEDIRQGKMVILMDDEDRENEGDLIMAAEHITPAAINFMATHGRGLICLTLTKERCRRLGLNPMVQDNNAQY
TTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAADLVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGLEPASV
IVEILNDDGTMARRPDLEVFAEKHGLKLGTIADLIEYRNHTETTIERVAQCKLPTEYGEFELVTYRDIIDKQIHFALRKG
DITSAPTLVRVHLQDTFTDLLHSNRAAERSWPLATAMQRIGQEGGVLVILGHEESSELLLHRVKMFELQDKGEAPAMAKK
QGTSRRVGVGSQILADLGVKEMRLLSSPNKKYHALGGFGLNVVEYVCE

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=205, Percent_Identity=54.1463414634146, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1787533, Length=168, Percent_Identity=33.9285714285714, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=43.1372549019608, Blast_Score=167, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40411; Mature: 40280

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISTPQEIIEDIRQGKMVILMDDEDRENEGDLIMAAEHITPAAINFMATHGRGLICLTL
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCHHHEEEEECCCCEEEEEE
TKERCRRLGLNPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAAD
CHHHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGLEPASVIVEILNDDGTMARRPDLEV
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHH
FAEKHGLKLGTIADLIEYRNHTETTIERVAQCKLPTEYGEFELVTYRDIIDKQIHFALRK
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHEEC
GDITSAPTLVRVHLQDTFTDLLHSNRAAERSWPLATAMQRIGQEGGVLVILGHEESSELL
CCCCCCCEEEEEEEHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCEEEEECCCCHHHHH
LHRVKMFELQDKGEAPAMAKKQGTSRRVGVGSQILADLGVKEMRLLSSPNKKYHALGGFG
HHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCEEEECCCC
LNVVEYVCE
HHHHHHHCC
>Mature Secondary Structure 
PISTPQEIIEDIRQGKMVILMDDEDRENEGDLIMAAEHITPAAINFMATHGRGLICLTL
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCHHHEEEEECCCCEEEEEE
TKERCRRLGLNPMVQDNNAQYTTNFTVSIEAAEGVTTGISAADRARTVQAAVAKEAKAAD
CHHHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVQPGHIFPLAAQDGGVLTRAGHTEAGCDLARLAGLEPASVIVEILNDDGTMARRPDLEV
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHH
FAEKHGLKLGTIADLIEYRNHTETTIERVAQCKLPTEYGEFELVTYRDIIDKQIHFALRK
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHEEC
GDITSAPTLVRVHLQDTFTDLLHSNRAAERSWPLATAMQRIGQEGGVLVILGHEESSELL
CCCCCCCEEEEEEEHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCEEEEECCCCHHHHH
LHRVKMFELQDKGEAPAMAKKQGTSRRVGVGSQILADLGVKEMRLLSSPNKKYHALGGFG
HHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCEEEECCCC
LNVVEYVCE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]