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The map label for this gene is hemA

Identifier: 147674777

GI number: 147674777

Start: 1877848

End: 1879107

Strand: Reverse

Name: hemA

Synonym: VC0395_A1757

Alternate gene names: 147674777

Gene position: 1879107-1877848 (Counterclockwise)

Preceding gene: 147673504

Following gene: 147674456

Centisome position: 62.14

GC content: 50.08

Gene sequence:

>1260_bases
ATGTCTTTGCTTGCCATTGGAATCAATCACAATACGGCGTCGGTAGAATTGCGGGAAAAAGTGGCGTTCGGTCCAGAGAA
GCTCTCTTTGGCGCTGAATCAGCTTTCCACCAGTTCACACGTTAAAGGAGGCGTGATCCTCTCAACGTGTAACCGCACCG
AAATTTATTGTGATGTGAGATCAGCAAGTAAAAACAAAGTCATCGAATGGTTGTCCCAGTTTCACCAAGTCAGCTTGGAT
GAGTTAAAACCCAGCCTATACGTTCATGAAGAGCAAGCCGCCATTCGTCATTTGATGCGTGTCGCCTGTGGTTTGGACTC
TCTAGTGTTGGGCGAGCCGCAGATATTAGGACAAGTTAAGCAAGCTTACGCAGAGGCGAGAGAGAATCACGCCGTCAATC
CGGCGACGGAAAAGCTGTTTCAAAAGGCTTTTTCGGTCGCGAAACGGGTAAGAACAGAAACCGAAATCGGCGGCAGCGCG
GTTTCGGTCGCTTATGCCGCTTGCACTTTAGCAAAACACATTTTTGAATCGCTGGCCGACGCTACGGTACTGTTGGTCGG
GGCTGGTGAAACCATTGAACTGGTAGCAAAACATTTGGCCGGACACCACTGTAAACGGATGATAGTGGCGAACCGCACGC
GAGAGCGAGCTTTGAGCTTAGCGCAGCAGTTTGGCGCCGACGTCATCGCATTAAATGAGATCCCAGACTATTTAGCGCAA
GCGGATATTGTGATCAGCTCGACCGCTAGCCCTTTGCCCATCATAGGTAAAGGCATGGTCGAAAGTGCACTAAAGGCCCG
TCGCCATCAGCCTATGTTGTTGGTGGATATTGCCGTGCCACGCGATATTGAGCCGCAGGTCGGTAAGCTTAACGATGCTT
ATCTCTATTCGGTCGATGACTTGCAGTCGATTGTCGATAGCAATATCGAGCAGCGCAAAGTGGAAGCGATTCAGGCAGAA
GCGATTGTCAGTGAAGAGAGCGCCACCTTCATGAGTTGGATGCGCTCACTGCAAGCGGTGGACAGTATTCGTGATTATCG
TAAGCAAGCCAATGAAGCGCGTGAAGAGCTACTCAATAAAAGTTTGCAAGCATTGGCAGCGGGTGGCGATCCTGAAAAGC
TGCTCATAGAATTAAGCAACAAACTGACCAACAAACTAATTCACACCCCAACCCGAGCGCTACAAACCGCGGCGGAACAA
GGGGAACCGGCTAAACTGGCCGTGATCAGACAAAGTTTAGGTCTTGACGATCTGAACTAA

Upstream 100 bases:

>100_bases
GAACTCAGGAAAACAAATCCGGTCTGCCCTTTCAATCAAAGAGGGCATCAAGTAAAATTCCGCCTCTAGTCCACCACACA
TATCTGAGAATCCTCTATAG

Downstream 100 bases:

>100_bases
ATCTCAACTTAGAGTTTAAAGAAGCAACTATGAAAGCGTCGATTTTAAGCAAGCTTGAATCCCTTGTTGAGCGCTATGAA
GAGGTTCAGCACCTCCTTGG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVRSASKNKVIEWLSQFHQVSLD
ELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSA
VSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQ
ADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAE
AIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQ
GEPAKLAVIRQSLGLDDLN

Sequences:

>Translated_419_residues
MSLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVRSASKNKVIEWLSQFHQVSLD
ELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSA
VSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQ
ADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAE
AIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQ
GEPAKLAVIRQSLGLDDLN
>Mature_418_residues
SLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVRSASKNKVIEWLSQFHQVSLDE
LKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSAV
SVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQA
DIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAEA
IVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQG
EPAKLAVIRQSLGLDDLN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=60.2870813397129, Blast_Score=506, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_VIBC3 (A5F697)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F697
- SMR:   A5F697
- STRING:   A5F697
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1757
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   VCHO345073:VC0395_A1757-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45745; Mature: 45614

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVR
CCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEEEC
SASKNKVIEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVK
CCCHHHHHHHHHHHHHCCHHHCCCCCEEEHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHH
QAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESLAD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
ATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQ
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHH
ADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDD
CCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEHHH
LQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQGEPAKLAVIRQSLGLDDLN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVR
CEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEEEC
SASKNKVIEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVK
CCCHHHHHHHHHHHHHCCHHHCCCCCEEEHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHH
QAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESLAD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
ATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQ
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHH
ADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDD
CCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEHHH
LQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQGEPAKLAVIRQSLGLDDLN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA