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The map label for this gene is fadE [H]

Identifier: 147674587

GI number: 147674587

Start: 1428630

End: 1430912

Strand: Reverse

Name: fadE [H]

Synonym: VC0395_A1340

Alternate gene names: 147674587

Gene position: 1430912-1428630 (Counterclockwise)

Preceding gene: 147674301

Following gene: 229259763

Centisome position: 47.32

GC content: 51.73

Gene sequence:

>2283_bases
ATGAGCTCTCTACGCAGAAAATGGATCAGCGATCCCGCTTTCAAAATGTTTAAGAAAGTGCTTCCTCCTCTGTCACAAAC
CGAGAAAGAAGCGATGGAAGCGGGCAGTGTATGGTGGGATGGCGAACTGTTCTCTGGTAAGCCTGATTTCACCAAGCTGC
ACCATTATCCGAAACCGACCTTGTCAGCGGAGGAGCAATCTTTCATCGACAACGAGTTGGAAACTCTGCTCGCTATGTTG
GATGACTACAAGATAGTCAAACAAGATCGCGATCTCCCCAAAGAGGTGTGGGACTACCTACGTAAAGAGCGTTTCTTCTC
GCTGATTATTTCCAAAGAGTATGGTGGCCGTGAGTTCTCGGCTCTGGCGAACTCGACCATAGTGTCACGCATTGCTACGC
GCAGCATCAGCACCGCAGTAACAGTCATGGTACCGAACTCATTGGGCCCTGGTGAGCTGTTGTCACACTACGGTACCCAA
GAGCAGAAAGATTACTGGCTGCCACGTTTGGCCGATGGCACCGATATTCCTTGCTTTGCATTGACAGGGCCGGAAGCGGG
TTCGGATGCGGGCAGCATTCCTGACCAAGGCGTGGTCTGCTACGGCAAGCATGAAGGCAAAGACGTGCTGGGCATCCGTT
TAAGCTGGAACAAGCGTTACATCACGCTGGCACCAGTGGCGACTGTGCTGGGTCTTGCTTTCAAACTGAGTGATCCAGAG
CATCTGCTTGGCGATAAAGAAGAGATTGGTATTACTTGTGCGCTAATCCCTGCCTCCCATGAAGGCGTAGAGATTGGCGA
ACGCCACGACCCACTAGGTTTGGCCTTTATGAACGGCCCAACCCGTGGCCAAGATGTGTTTATCCCAATGGATTGGCTGA
TTGGTGGGGCGGATTACGCAGGTAAAGGCTGGCGCATGTTGGTGGAGTGTCTCTCGGCAGGACGTGGGATCTCCCTACCT
GCATTGGGTACCGCGATTGGCCACCTCACCGCTCGTACCACAGGCGCATATGGTTATGTGCGTAAGCAGTTTGGGATGTC
GATTGGTAAATTTGAAGGTGTGGCGGAAGCCATGGGACGTATCGGCGGTTTAACCTACTTGCTGGAAGCGACCCGTACTT
TGACCACCACCTCTTTGGATCTCAAAGAGAAACCAGGGATTGTCACGGCGATTGCCAAATACCACATGACGGAAATCGCG
CGCACCATTTTGAATGATGCGATGGATATCCATTCTGGTCGTGCTATCCAAGATGGACCAATGAACTATCTGGCGACGCA
CTATCTCGGCGTACCCGTGGCAATCACGGTTGAAGGGGCGAACATTTTGACGCGTAACCTGATGATCTTCGGTCAAGGTG
CGACTCGTTGCCATCCTTATGTTCTCAAAGAGATGGAAGCGGCGGCCAACCCAGATCAACAAGAAGGGGCAAAAGCGTTT
GATGAACTGCTGTTCAAGCACATTGCCCACGCGACCAAAAACAGCTTTGGTGCTCTGTTTGCCGCACTGACGGGTTCACG
CTTTATTAAAGCGAACATGAGTGGCCCCACACAAGACTACTATAAGCAGATGACTCGCCTGAGCCGCGCTTTAGCGGTGA
GTGCGGATGTGGCAATGCTCACCTTGGGTGGCGAGCTCAAACGTAAAGAGATGATTTCAGCACGCTTAGGCGATGCACTG
AGCTATCTGTACATGGGCTCGGCGGTACTGAAAAAGTATGAAGATGAAGGCCGCCATCAAGCGGATTTAGACTACGTACA
CTATGCGATGCAGTACTGTTTACATCACGCGGCGAAATCGCTTAACCAAGCGTATCGTAACTACCCTGTGACTGGGGTCG
GAGCCATCTTGAAAGGGCTGCTGTTCCCGCTAGGCAACCACTTTGCACCACCGAGTGATGAGTTAGCGGTCAAACTCGCA
GAAAGTCTGATGACCCCTGGAGCGCATCGTGATCGTTTAACCGCGCTGTGCTACATAGGTAAAGGTGAAGATGACAGCGT
AGGCTTGATGGAAAAAGCGTTTTTGGCCATGTATAGCGTTAAAGGCTTAGAGCGTAAACTGCAACAAGGGGTGAAAGAGG
GTAAAGTGGCGCGCAAAGGACTACTGGTTGATCGCTTGGCACAAGCAGAGCAAGCGGATGTGTTGAGCGCAGATGAAGTG
GCCTCGATTCTGGCGGCAGAAAAACTGCGTAGCCGTGCGATTCAGGTCGATCATTTCAGCCATGATTTCTCGCAAATCCA
TACCCATCAGACCACCAAACCTAAGTTAAACAGTGTGGCGTAA

Upstream 100 bases:

>100_bases
GATCAACTGATTCCATACCTCGCGGCCGGTGTGGCGGCGAAATAACTAACCGATTCATAACAAAAATAACAGTGTAACCA
GTGAACAAAAGGATCTGAAT

Downstream 100 bases:

>100_bases
CAAATAAAATAGAGTATCGAGGGCTTCTCATCAGAAGCCCTCTTTATTTTTATTGATTGAGTTTTTTGTGAGCATAACGG
GAAAAATCCCCCAATGAGTG

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MSSLRRKWISDPAFKMFKKVLPPLSQTEKEAMEAGSVWWDGELFSGKPDFTKLHHYPKPTLSAEEQSFIDNELETLLAML
DDYKIVKQDRDLPKEVWDYLRKERFFSLIISKEYGGREFSALANSTIVSRIATRSISTAVTVMVPNSLGPGELLSHYGTQ
EQKDYWLPRLADGTDIPCFALTGPEAGSDAGSIPDQGVVCYGKHEGKDVLGIRLSWNKRYITLAPVATVLGLAFKLSDPE
HLLGDKEEIGITCALIPASHEGVEIGERHDPLGLAFMNGPTRGQDVFIPMDWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAIGHLTARTTGAYGYVRKQFGMSIGKFEGVAEAMGRIGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEIA
RTILNDAMDIHSGRAIQDGPMNYLATHYLGVPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDQQEGAKAF
DELLFKHIAHATKNSFGALFAALTGSRFIKANMSGPTQDYYKQMTRLSRALAVSADVAMLTLGGELKRKEMISARLGDAL
SYLYMGSAVLKKYEDEGRHQADLDYVHYAMQYCLHHAAKSLNQAYRNYPVTGVGAILKGLLFPLGNHFAPPSDELAVKLA
ESLMTPGAHRDRLTALCYIGKGEDDSVGLMEKAFLAMYSVKGLERKLQQGVKEGKVARKGLLVDRLAQAEQADVLSADEV
ASILAAEKLRSRAIQVDHFSHDFSQIHTHQTTKPKLNSVA

Sequences:

>Translated_760_residues
MSSLRRKWISDPAFKMFKKVLPPLSQTEKEAMEAGSVWWDGELFSGKPDFTKLHHYPKPTLSAEEQSFIDNELETLLAML
DDYKIVKQDRDLPKEVWDYLRKERFFSLIISKEYGGREFSALANSTIVSRIATRSISTAVTVMVPNSLGPGELLSHYGTQ
EQKDYWLPRLADGTDIPCFALTGPEAGSDAGSIPDQGVVCYGKHEGKDVLGIRLSWNKRYITLAPVATVLGLAFKLSDPE
HLLGDKEEIGITCALIPASHEGVEIGERHDPLGLAFMNGPTRGQDVFIPMDWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAIGHLTARTTGAYGYVRKQFGMSIGKFEGVAEAMGRIGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEIA
RTILNDAMDIHSGRAIQDGPMNYLATHYLGVPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDQQEGAKAF
DELLFKHIAHATKNSFGALFAALTGSRFIKANMSGPTQDYYKQMTRLSRALAVSADVAMLTLGGELKRKEMISARLGDAL
SYLYMGSAVLKKYEDEGRHQADLDYVHYAMQYCLHHAAKSLNQAYRNYPVTGVGAILKGLLFPLGNHFAPPSDELAVKLA
ESLMTPGAHRDRLTALCYIGKGEDDSVGLMEKAFLAMYSVKGLERKLQQGVKEGKVARKGLLVDRLAQAEQADVLSADEV
ASILAAEKLRSRAIQVDHFSHDFSQIHTHQTTKPKLNSVA
>Mature_759_residues
SSLRRKWISDPAFKMFKKVLPPLSQTEKEAMEAGSVWWDGELFSGKPDFTKLHHYPKPTLSAEEQSFIDNELETLLAMLD
DYKIVKQDRDLPKEVWDYLRKERFFSLIISKEYGGREFSALANSTIVSRIATRSISTAVTVMVPNSLGPGELLSHYGTQE
QKDYWLPRLADGTDIPCFALTGPEAGSDAGSIPDQGVVCYGKHEGKDVLGIRLSWNKRYITLAPVATVLGLAFKLSDPEH
LLGDKEEIGITCALIPASHEGVEIGERHDPLGLAFMNGPTRGQDVFIPMDWLIGGADYAGKGWRMLVECLSAGRGISLPA
LGTAIGHLTARTTGAYGYVRKQFGMSIGKFEGVAEAMGRIGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEIAR
TILNDAMDIHSGRAIQDGPMNYLATHYLGVPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDQQEGAKAFD
ELLFKHIAHATKNSFGALFAALTGSRFIKANMSGPTQDYYKQMTRLSRALAVSADVAMLTLGGELKRKEMISARLGDALS
YLYMGSAVLKKYEDEGRHQADLDYVHYAMQYCLHHAAKSLNQAYRNYPVTGVGAILKGLLFPLGNHFAPPSDELAVKLAE
SLMTPGAHRDRLTALCYIGKGEDDSVGLMEKAFLAMYSVKGLERKLQQGVKEGKVARKGLLVDRLAQAEQADVLSADEVA
SILAAEKLRSRAIQVDHFSHDFSQIHTHQTTKPKLNSVA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=391, Percent_Identity=28.9002557544757, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI4557233, Length=356, Percent_Identity=28.9325842696629, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI4501859, Length=409, Percent_Identity=26.4058679706601, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI4557235, Length=415, Percent_Identity=24.578313253012, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI76496475, Length=390, Percent_Identity=24.6153846153846, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI7656849, Length=325, Percent_Identity=24.6153846153846, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI87081702, Length=740, Percent_Identity=51.7567567567568, Blast_Score=783, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=28.9972899728997, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=276, Percent_Identity=28.9855072463768, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=382, Percent_Identity=25.130890052356, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=269, Percent_Identity=27.8810408921933, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=347, Percent_Identity=24.4956772334294, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71982178, Length=291, Percent_Identity=28.1786941580756, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281363737, Length=524, Percent_Identity=23.2824427480916, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356377, Length=399, Percent_Identity=26.5664160401003, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24666513, Length=298, Percent_Identity=29.1946308724832, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 83378; Mature: 83246

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLRRKWISDPAFKMFKKVLPPLSQTEKEAMEAGSVWWDGELFSGKPDFTKLHHYPKPT
CCHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCEEECCEECCCCCCHHHHCCCCCCC
LSAEEQSFIDNELETLLAMLDDYKIVKQDRDLPKEVWDYLRKERFFSLIISKEYGGREFS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHH
ALANSTIVSRIATRSISTAVTVMVPNSLGPGELLSHYGTQEQKDYWLPRLADGTDIPCFA
HHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTGPEAGSDAGSIPDQGVVCYGKHEGKDVLGIRLSWNKRYITLAPVATVLGLAFKLSDPE
ECCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHCCCCCH
HLLGDKEEIGITCALIPASHEGVEIGERHDPLGLAFMNGPTRGQDVFIPMDWLIGGADYA
HHCCCCHHCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEHHHHCCCCCCC
GKGWRMLVECLSAGRGISLPALGTAIGHLTARTTGAYGYVRKQFGMSIGKFEGVAEAMGR
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHH
IGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEIARTILNDAMDIHSGRAIQDGP
HHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
MNYLATHYLGVPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDQQEGAKAF
HHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHH
DELLFKHIAHATKNSFGALFAALTGSRFIKANMSGPTQDYYKQMTRLSRALAVSADVAML
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEE
TLGGELKRKEMISARLGDALSYLYMGSAVLKKYEDEGRHQADLDYVHYAMQYCLHHAAKS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LNQAYRNYPVTGVGAILKGLLFPLGNHFAPPSDELAVKLAESLMTPGAHRDRLTALCYIG
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEC
KGEDDSVGLMEKAFLAMYSVKGLERKLQQGVKEGKVARKGLLVDRLAQAEQADVLSADEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ASILAAEKLRSRAIQVDHFSHDFSQIHTHQTTKPKLNSVA
HHHHHHHHHHHHCEEEHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SSLRRKWISDPAFKMFKKVLPPLSQTEKEAMEAGSVWWDGELFSGKPDFTKLHHYPKPT
CHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCEEECCEECCCCCCHHHHCCCCCCC
LSAEEQSFIDNELETLLAMLDDYKIVKQDRDLPKEVWDYLRKERFFSLIISKEYGGREFS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHH
ALANSTIVSRIATRSISTAVTVMVPNSLGPGELLSHYGTQEQKDYWLPRLADGTDIPCFA
HHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTGPEAGSDAGSIPDQGVVCYGKHEGKDVLGIRLSWNKRYITLAPVATVLGLAFKLSDPE
ECCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHCCCCCH
HLLGDKEEIGITCALIPASHEGVEIGERHDPLGLAFMNGPTRGQDVFIPMDWLIGGADYA
HHCCCCHHCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEHHHHCCCCCCC
GKGWRMLVECLSAGRGISLPALGTAIGHLTARTTGAYGYVRKQFGMSIGKFEGVAEAMGR
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHH
IGGLTYLLEATRTLTTTSLDLKEKPGIVTAIAKYHMTEIARTILNDAMDIHSGRAIQDGP
HHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
MNYLATHYLGVPVAITVEGANILTRNLMIFGQGATRCHPYVLKEMEAAANPDQQEGAKAF
HHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHH
DELLFKHIAHATKNSFGALFAALTGSRFIKANMSGPTQDYYKQMTRLSRALAVSADVAML
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEE
TLGGELKRKEMISARLGDALSYLYMGSAVLKKYEDEGRHQADLDYVHYAMQYCLHHAAKS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LNQAYRNYPVTGVGAILKGLLFPLGNHFAPPSDELAVKLAESLMTPGAHRDRLTALCYIG
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEC
KGEDDSVGLMEKAFLAMYSVKGLERKLQQGVKEGKVARKGLLVDRLAQAEQADVLSADEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ASILAAEKLRSRAIQVDHFSHDFSQIHTHQTTKPKLNSVA
HHHHHHHHHHHHCEEEHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]