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The map label for this gene is hpt [H]

Identifier: 147674548

GI number: 147674548

Start: 104257

End: 104790

Strand: Direct

Name: hpt [H]

Synonym: VC0395_A0117

Alternate gene names: 147674548

Gene position: 104257-104790 (Clockwise)

Preceding gene: 147673119

Following gene: 147673337

Centisome position: 3.45

GC content: 44.01

Gene sequence:

>534_bases
ATGAAACACACAGTTGAAGTCATGATTTCTGAGCAAGAGGTCGCCCAGCGCATTCGCGAATTAGGTCAACAGATCACTGA
GCATTATCAAGGGAGTAGTGATTTAGTTTTGGTTGGATTGCTGCGTGGTTCTTTTGTTTTTATGGCGGATCTTGCTCGTC
AAATTCATCTGACTCATCAAGTCGATTTTATGACCGCCTCTAGCTATGGCAACAGTATGCAAAGCTCACGTGATGTGCGC
ATTCTGAAAGATCTCGATGATGACATCAAAGGTAAAGATGTATTGCTGGTGGAAGATATTATCGATACAGGGAATACCTT
AAACAAAGTGAAAGAGATTCTGGCGCTGCGTGAGCCTAAATCGATCCGTATTTGCACACTATTGGATAAGCCAACCCGTC
GTGAAGTGGACGTTGAAGTGAATTGGGTCGGTTTTGAAATTCCTGACGAATTTGTGGTCGGTGTCGGTATCGACTACGCG
CAGAAATATCGTCACCTACCTTATATTGGCAAAGTGGTGCCTTTGGCGGAATAA

Upstream 100 bases:

>100_bases
AGGATGAGTAGGGAAACGATTAACAGGATTTGAGTGAAGTGGTACTATACGCGCCACCAAAGTCAGCGATACTGACATCG
CCCAACACAACGAGAATGGT

Downstream 100 bases:

>100_bases
CCTAAGCTCACGATTGACAATAAAAGATTGCCGACAACGCCCACGCACTCGTGGGCGTTGCTCTTTGGAGAGAATTAACG
ACACAGTAGGCGATGATTCG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MKHTVEVMISEQEVAQRIRELGQQITEHYQGSSDLVLVGLLRGSFVFMADLARQIHLTHQVDFMTASSYGNSMQSSRDVR
ILKDLDDDIKGKDVLLVEDIIDTGNTLNKVKEILALREPKSIRICTLLDKPTRREVDVEVNWVGFEIPDEFVVGVGIDYA
QKYRHLPYIGKVVPLAE

Sequences:

>Translated_177_residues
MKHTVEVMISEQEVAQRIRELGQQITEHYQGSSDLVLVGLLRGSFVFMADLARQIHLTHQVDFMTASSYGNSMQSSRDVR
ILKDLDDDIKGKDVLLVEDIIDTGNTLNKVKEILALREPKSIRICTLLDKPTRREVDVEVNWVGFEIPDEFVVGVGIDYA
QKYRHLPYIGKVVPLAE
>Mature_177_residues
MKHTVEVMISEQEVAQRIRELGQQITEHYQGSSDLVLVGLLRGSFVFMADLARQIHLTHQVDFMTASSYGNSMQSSRDVR
ILKDLDDDIKGKDVLLVEDIIDTGNTLNKVKEILALREPKSIRICTLLDKPTRREVDVEVNWVGFEIPDEFVVGVGIDYA
QKYRHLPYIGKVVPLAE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=175, Percent_Identity=34.8571428571429, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=32.3699421965318, Blast_Score=87, Evalue=8e-18,
Organism=Escherichia coli, GI87081689, Length=178, Percent_Identity=73.5955056179775, Blast_Score=276, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17510817, Length=177, Percent_Identity=36.7231638418079, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20109; Mature: 20109

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTVEVMISEQEVAQRIRELGQQITEHYQGSSDLVLVGLLRGSFVFMADLARQIHLTHQ
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHH
VDFMTASSYGNSMQSSRDVRILKDLDDDIKGKDVLLVEDIIDTGNTLNKVKEILALREPK
EEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SIRICTLLDKPTRREVDVEVNWVGFEIPDEFVVGVGIDYAQKYRHLPYIGKVVPLAE
CEEEEEECCCCCCCEEEEEEEEEEEECCCCEEEECCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKHTVEVMISEQEVAQRIRELGQQITEHYQGSSDLVLVGLLRGSFVFMADLARQIHLTHQ
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHH
VDFMTASSYGNSMQSSRDVRILKDLDDDIKGKDVLLVEDIIDTGNTLNKVKEILALREPK
EEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SIRICTLLDKPTRREVDVEVNWVGFEIPDEFVVGVGIDYAQKYRHLPYIGKVVPLAE
CEEEEEECCCCCCCEEEEEEEEEEEECCCCEEEECCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]