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The map label for this gene is bioA [H]

Identifier: 147674377

GI number: 147674377

Start: 671282

End: 672568

Strand: Reverse

Name: bioA [H]

Synonym: VC0395_A0629

Alternate gene names: 147674377

Gene position: 672568-671282 (Counterclockwise)

Preceding gene: 147675640

Following gene: 147674360

Centisome position: 22.24

GC content: 50.58

Gene sequence:

>1287_bases
ATGATGATGGATTTAGCCTTCGACCGTTGCCACATCTGGCATCCCTACACTTCGACCTTGACACCTCTGACCTGTTATCC
GGTAAGCCGAGCCGATGGCGTAATGATCACACTTGAAGATGGGCGCAGCTTAGTTGACGGCATGTCCTCTTGGTGGGCAG
CGATCCACGGTTACAATCACCCCAAACTCAATCAAGCGGCGCACCAGCAAATCGAGCAGATGTCACACATCATGTTTGGT
GGGTTAACTCATCAACCGGCGATTGAGCTTTGCCAAAAGCTACTCAAGCTCGCGCCCAACAATTTACAGCAAGTGTTTCT
CGCCGATTCAGGTTCGGTTGCGGTGGAAGTGAGCCTTAAAATGGCGTTGCAGTATTGGCACAGCAAAGGTCAACCGAGAG
CAAAGTTTCTCACCCTACGCCACGGCTACCACGGCGATACCTTCGCCGCGATGTCAGTGACCGATCCAGATAACTCCATG
CATAGCCTGTACAAAGGTTTTCTGCCCGAGCATATTTTCGCTAATTCGCCAGAAGGCGGATTTTTTGATGCGTGGGATGA
GCGTGATATTGCCGATTTTCGTCACAAATTGACTGAACATCACCACCAGATTGCCGCCGTAATCCTTGAACCTATCGTGC
AAGGGGCTGGTGGTATGCGTATCTATCACCCCGAGTTTTTACGCCAAGTTAGAGCTTTGTGTGACGAATTTGGTGTACTG
CTGATTTTGGATGAGATTGCGACCGGCTTTGGCCGCACAGGCAAACTCTTTGCTTGTGAACATGCGGGAATTCAACCGGA
TATTCTCTGTGTGGGCAAGGCGCTGACTGGCGGATACATGACGCTATCCGCTACCCTCACTACCCAACAAGTGGCCGATA
CCGTTTGTGCGGGGGAAGCAGGCTGCTTTATGCATGGCCCAACTTTTATGGGCAATCCGCTGGCTTGCGCGGTGGCGAGT
GCGAGTTTATCGCTGATTGAGCAAGGGGATTGGCAACAGCAAGTCGCGAATATTGAAGCGTTTTTTGCCGAGCAACTGCC
TAAACTCAATAATTTTTCACTAGTGAAACAGACTCGTTGGCTAGGCGCGATTGGTGTGGTGGAGACACATTTTCCGGTCA
ATATGGAAGTGATTCAGGCTCTCTTTGTGGAGCATGGGGTTTGGATCCGACCCTTTGGTCGGTTGATTTACCTGATGCCA
CCCTATATTAGTCAACCTGAACATCTGCAAAAGCTGGTGGATGCAATGGCAGCCGCGTTAAGCCAACCAAACTGCTTTAA
GCAATAG

Upstream 100 bases:

>100_bases
TTTATGCTTGGCTAGTCTACTGACAGGCGTTAGACTGTCAACAATAAGAAAATCACAAGGTTTACATGTGGTTATTAATT
AATCTTTTATTAATTTTGGA

Downstream 100 bases:

>100_bases
ACAATATGCTGCGCAACAAACGACAAGCATAAAAAAGCCGACATCACGTCGGCTTTTTTCATTCTTATACGTTTTGAGCG
CTAATTTCCCTTTAAAGGAA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNHPKLNQAAHQQIEQMSHIMFG
GLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLKMALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSM
HSLYKGFLPEHIFANSPEGGFFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEAGCFMHGPTFMGNPLACAVAS
ASLSLIEQGDWQQQVANIEAFFAEQLPKLNNFSLVKQTRWLGAIGVVETHFPVNMEVIQALFVEHGVWIRPFGRLIYLMP
PYISQPEHLQKLVDAMAAALSQPNCFKQ

Sequences:

>Translated_428_residues
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNHPKLNQAAHQQIEQMSHIMFG
GLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLKMALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSM
HSLYKGFLPEHIFANSPEGGFFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEAGCFMHGPTFMGNPLACAVAS
ASLSLIEQGDWQQQVANIEAFFAEQLPKLNNFSLVKQTRWLGAIGVVETHFPVNMEVIQALFVEHGVWIRPFGRLIYLMP
PYISQPEHLQKLVDAMAAALSQPNCFKQ
>Mature_428_residues
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNHPKLNQAAHQQIEQMSHIMFG
GLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLKMALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSM
HSLYKGFLPEHIFANSPEGGFFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEAGCFMHGPTFMGNPLACAVAS
ASLSLIEQGDWQQQVANIEAFFAEQLPKLNNFSLVKQTRWLGAIGVVETHFPVNMEVIQALFVEHGVWIRPFGRLIYLMP
PYISQPEHLQKLVDAMAAALSQPNCFKQ

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=28.9855072463768, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=30.7936507936508, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI13994255, Length=359, Percent_Identity=28.4122562674095, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=25.1781472684086, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=26.0204081632653, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI226442705, Length=384, Percent_Identity=25.2604166666667, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=66.5882352941177, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI145693181, Length=306, Percent_Identity=37.2549019607843, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789016, Length=351, Percent_Identity=30.1994301994302, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788044, Length=403, Percent_Identity=29.5285359801489, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789759, Length=343, Percent_Identity=31.4868804664723, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1787560, Length=353, Percent_Identity=29.4617563739377, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=28.2674772036474, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=429, Percent_Identity=26.8065268065268, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=26.0969976905312, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=285, Percent_Identity=29.1228070175439, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=23.1651376146789, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=430, Percent_Identity=23.2558139534884, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=46.4052287581699, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=29.4117647058824, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=391, Percent_Identity=26.8542199488491, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=324, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=28.0871670702179, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI161085790, Length=363, Percent_Identity=27.5482093663912, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574759, Length=363, Percent_Identity=27.5482093663912, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21356575, Length=353, Percent_Identity=25.2124645892351, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281366494, Length=444, Percent_Identity=24.7747747747748, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667139, Length=444, Percent_Identity=24.7747747747748, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667143, Length=444, Percent_Identity=24.7747747747748, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47528; Mature: 47528

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNH
CCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
PKLNQAAHQQIEQMSHIMFGGLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLK
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHH
MALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSMHSLYKGFLPEHIFANSPEGG
HHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCC
FFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCE
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEA
EEHHHHHHCCCCCCCEEEECCCCCCCCEEEEECHHCCCEEEEEEEHHHHHHHHHHHCCCC
GCFMHGPTFMGNPLACAVASASLSLIEQGDWQQQVANIEAFFAEQLPKLNNFSLVKQTRW
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LGAIGVVETHFPVNMEVIQALFVEHGVWIRPFGRLIYLMPPYISQPEHLQKLVDAMAAAL
HHEECEEECCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHH
SQPNCFKQ
CCCCCCCC
>Mature Secondary Structure
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNH
CCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
PKLNQAAHQQIEQMSHIMFGGLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLK
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHH
MALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSMHSLYKGFLPEHIFANSPEGG
HHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCC
FFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCE
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEA
EEHHHHHHCCCCCCCEEEECCCCCCCCEEEEECHHCCCEEEEEEEHHHHHHHHHHHCCCC
GCFMHGPTFMGNPLACAVASASLSLIEQGDWQQQVANIEAFFAEQLPKLNNFSLVKQTRW
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LGAIGVVETHFPVNMEVIQALFVEHGVWIRPFGRLIYLMPPYISQPEHLQKLVDAMAAAL
HHEECEEECCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHH
SQPNCFKQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]