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The map label for this gene is zot [H]

Identifier: 147674144

GI number: 147674144

Start: 1116043

End: 1117242

Strand: Reverse

Name: zot [H]

Synonym: VC0395_A1061

Alternate gene names: 147674144

Gene position: 1117242-1116043 (Counterclockwise)

Preceding gene: 147675552

Following gene: 147673805

Centisome position: 36.94

GC content: 49.25

Gene sequence:

>1200_bases
ATGAGTATCTTTATTCATCACGGCGCGCCAGGCTCTTATAAAACGTCCGGGGCATTATGGCTTCGTCTGCTGCCGGCGAT
TAAGTCAGGCCGTCACATCATCACGAATGTGCGAGGCTTAAACCTTGAACGCATAGCTAAGTACTTAAAAATGGACGTCT
CAGACATCAGTATCGAGTTTATTGATACAGACCATCCAGACGGTCGCTTAACGATGGCGCGTTTTTGGCACTGGGCGAGA
AAGGACGCGTTTCTCTTTATTGATGAATGTGGTCGCATCTGGCCGCCGAGACTGACGGCCACCAATTTAAAGGCGCTCGA
CACGCCGCCGGATTTGGTCGCAGAGGATAGGCCTGAGAGCTTTGAGGTGGCTTTTGACATGCATCGTCACCACGGCTGGG
ATATCTGCCTAACCACGCCTAACATTGCCAAAGTGCACAACATGATAAGAGAGGCGGCGGAGATAGGGTATCGCCACTTT
AACCGCGCCACGGTGGGGCTAGGGGCAAAGTTTACCCTGACCACCCACGATGCAGCCAACTCTGGACAGATGGATTCGCA
CGCGCTGACACGCCAAGTCAAAAAAATTCCAAGTCCGATTTTTAAGATGTACGCAAGCACCACCACAGGCAAAGCACGCG
ACACGATGGCCGGAACGGCGCTGTGGAAAGACAGAAAGATCCTTTTCTTGTTCGGCATGGTTTTTTTGATGTTCTCTTAT
TCGTTTTACGGCTTACACGACAATCCAATTTTTACAGGGGGAAATGATGCAACTATCGAGTCAGAGCAATCCGAGCCTCA
GTCAAAGGCTACTGCTGGGAATGCTGTCGGGAGCAAGGCGGCTGCTCCTGCGTCTTTTGGTTTTTGTATTGGTCGGCTTT
GTGTCCAAGATGGTTTTGTCACTGTTGGTGATGAGCGTTATCGCCTCGTAGACAATTTGGACATTCCTTATCGTGGTCTA
TGGGCGACAGGTCATCACATTTACAAGGATACGCTTACAGTGTTTTTTGAAACCGAGAGTGGCAGCGTCCCAACAGAGCT
GTTTGCATCGAGCTACCGCTACAAGGTGCTACCGTTACCGGATTTCAATCACTTTGTGGTGTTCGATACCTTTGCAGCGC
AAGCGCTGTGGGTAGAAGTGAAACGGGGTTTACCGATAAAAACAGAAAATGATAAAAAAGGACTAAATAGTATATTTTGA

Upstream 100 bases:

>100_bases
CTCAATACAGCGGCTTTCTGTTCTTTTTAGGGTTAGACCAAGCGCTGGCTATCGTGCTTCAGGCTTTGATGACCCGTTTC
GCCCTGCGAGCGTTAAACCT

Downstream 100 bases:

>100_bases
TTTTTGATTTTTGATTTTTGATTTTTGATTTTTGATTTTTGATTTCAAATAATACAAATTTATTTACTTATTTAATTGTT
TTGATCAATTATTTTTCTGT

Product: zona occludens toxin

Products: NA

Alternate protein names: Zonular occludens toxin; Zot [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEFIDTDHPDGRLTMARFWHWAR
KDAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPESFEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHF
NRATVGLGAKFTLTTHDAANSGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSY
SFYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFVTVGDERYRLVDNLDIPYRGL
WATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLPDFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF

Sequences:

>Translated_399_residues
MSIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEFIDTDHPDGRLTMARFWHWAR
KDAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPESFEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHF
NRATVGLGAKFTLTTHDAANSGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSY
SFYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFVTVGDERYRLVDNLDIPYRGL
WATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLPDFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF
>Mature_398_residues
SIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEFIDTDHPDGRLTMARFWHWARK
DAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPESFEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHFN
RATVGLGAKFTLTTHDAANSGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSYS
FYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFVTVGDERYRLVDNLDIPYRGLW
ATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLPDFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF

Specific function: Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens) [H]

COG id: COG4128

COG function: function code R; Zonula occludens toxin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008900 [H]

Pfam domain/function: PF05707 Zot [H]

EC number: NA

Molecular weight: Translated: 44802; Mature: 44670

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEF
CEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEE
IDTDHPDGRLTMARFWHWARKDAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPES
EECCCCCCCEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCHHCCCCCCC
FEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHFNRATVGLGAKFTLTTHDAAN
EEEEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCC
SGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSY
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SFYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFV
CEEEECCCCEEECCCCCEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
TVGDERYRLVDNLDIPYRGLWATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLP
EECCCCEEEECCCCCCCCEEECCCCEEEEEEEEEEEECCCCCCCHHHHHCCCCEEEEECC
DFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF
CCCCEEEEECHHHHEEEEEHHCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure 
SIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEF
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEE
IDTDHPDGRLTMARFWHWARKDAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPES
EECCCCCCCEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCHHCCCCCCC
FEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHFNRATVGLGAKFTLTTHDAAN
EEEEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCC
SGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSY
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SFYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFV
CEEEECCCCEEECCCCCEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
TVGDERYRLVDNLDIPYRGLWATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLP
EECCCCEEEECCCCCCCCEEECCCCEEEEEEEEEEEECCCCCCCHHHHHCCCCEEEEECC
DFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF
CCCCEEEEECHHHHEEEEEHHCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1730472; 10952301; 2052603 [H]