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The map label for this gene is pdxA

Identifier: 147674027

GI number: 147674027

Start: 3014622

End: 3015614

Strand: Reverse

Name: pdxA

Synonym: VC0395_A2862

Alternate gene names: 147674027

Gene position: 3015614-3014622 (Counterclockwise)

Preceding gene: 147674503

Following gene: 147673129

Centisome position: 99.72

GC content: 50.15

Gene sequence:

>993_bases
ATGAGCAGTAAACGCATCATTGTCACAGCCGGTGAGCCCGCGGGGATCGGTCCCGATCTGGTGCTCGCCCTCTCCGCGCA
AGATTGGCCACATCAACTGGTGGTGTGTGCCGATAAGGCGTTATTGGCGCAGCGGGCCACGCAACTTGGCATACAGGTTA
AGCTACTGGATTATCAACGCGATAATCCAGTGCAAGCGCAACAAGCAGGAACCTTGTTGGTTGAGCATATTCCTCTCGCG
GAACCCGTCGTCGCCGGTCAACTCAATCCAGCGAATGGACACTATGTGTTAAAAACGCTGGAAAGAGCGGCAAAAGGCTG
TATGAATGGCGAATTTGATGCTATTGTCACCGGCCCTGTGCACAAGGGGGTGATCAACCGTGCGGGGGTGGCTTTCAGCG
GTCATACCGAATTTTTTGCTGAACAGTCAAAAACTCCCCTCGTCGTGATGATGCTGGCCACAGAAGGCTTACGTACTGCG
TTAGTCACTACACATCTGCCACTCGCAGAAGTGCCGCAAGCGATAACTTGTGAACGTCTAGAACAGATTGTTCATATTCT
CCACAAGGATTTAGTCGAGAAATTTGCCATTGCTGAGCCTAAAATCTACGTATGTGGGTTAAATCCACACGCAGGTGAAG
ACGGTGTATTGGGCATGGATGAGATCGAAACCATCACTCCTACCCTACAGCGTTTGCGTGAGCAATATGGCATGCAATTG
GTTGGTCCTTTACCAGCCGATACTATTTTTAGTGAAAAATACTTGCAACAAGCGGATGCCGTTCTCGGCATGTACCATGA
TCAAGTGCTTCCAGTGCTGAAATACAAAGGCTTTGGCCGCTCAGTCAATATTACGCTCGGGCTGCCTTTTATCCGCACTT
CGGTCGATCACGGTACGGCACTCGATCTGGCTGGAACGGGTCAAGCCGATGCGGGAAGCTTTTGGACTGCATTAGCTTAC
GCAATTGAATTAGTTGATAAAAAAGCGCAATAA

Upstream 100 bases:

>100_bases
TACCGTATCTTGTTCAATCGTAAATTCAATGAAGAAGCCAGTGCTTGGCTGCAAGAGCTGCGTGCCAGCGCCTTTGTTGA
AGTATTGAAGGACGAGAAGG

Downstream 100 bases:

>100_bases
CTTAGAGAAAACTATGAGAAATGATGTCCACTTAGGGCACAAAGCGCGTAAACGCTTTGGTCAGAACTTCCTCAATGATC
CTTACATCATTGATGGTATT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLA
EPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTA
LVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAY
AIELVDKKAQ

Sequences:

>Translated_330_residues
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLA
EPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTA
LVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAY
AIELVDKKAQ
>Mature_329_residues
SSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLAE
PVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTAL
VTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQLV
GPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYA
IELVDKKAQ

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=325, Percent_Identity=62.7692307692308, Blast_Score=415, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_VIBCH (Q9KUS1)

Other databases:

- EMBL:   AE003852
- PIR:   C82323
- RefSeq:   NP_230098.1
- ProteinModelPortal:   Q9KUS1
- SMR:   Q9KUS1
- GeneID:   2615776
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0444
- TIGR:   VC_0444
- HOGENOM:   HBG451136
- OMA:   VHKANIN
- ProtClustDB:   PRK00232
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35606; Mature: 35474

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: BINDING 135-135 BINDING 136-136 BINDING 274-274 BINDING 283-283 BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCEEEEEEECCC
DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPV
CCCCCHHHHCCEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCH
HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL
HHHHHHHCCEEECCCHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCHHHCCCHHHHHHH
EQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHEECCCCCCE
LDLAGTGQADAGSFWTALAYAIELVDKKAQ
EEECCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR
CCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCEEEEEEECCC
DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPV
CCCCCHHHHCCEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCH
HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL
HHHHHHHCCEEECCCHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCHHHCCCHHHHHHH
EQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHEECCCCCCE
LDLAGTGQADAGSFWTALAYAIELVDKKAQ
EEECCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301