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The map label for this gene is bioC [H]

Identifier: 147673959

GI number: 147673959

Start: 674747

End: 675685

Strand: Direct

Name: bioC [H]

Synonym: VC0395_A0632

Alternate gene names: 147673959

Gene position: 674747-675685 (Clockwise)

Preceding gene: 147675336

Following gene: 147675610

Centisome position: 22.31

GC content: 50.59

Gene sequence:

>939_bases
TTGGGTGAGTGCCATTCGACCACCCACCGTGCCTGTAGGCAGTGCGCGTTTACGTATCACGATAACGGCGGCGCATACCC
AAGCGCAGATACGCCGCTTATCGGAGCAGTTAAAACATGTGATGGAGAAGGACACATGAGCATGACAGCCACGGAGCTTT
GTGTTGAATTAAAAGACAAAAGTGCGATTGCGCAAGCCTTTGGCAAAGCCGCCGCGCACTATGATCAGCACGCGGCTTTT
CAGCGCGATGTCGGATTGCGTTTACTGCAAAAAATGCCCAGTTGTCTGAAGGGGCTGCGAGTATTGGATCTCGGTTGTGG
TACCGGTTATTTTTCAGCCTTGCTACGCGAGCGGGGAGCGCAAGTGGTGTGCGCCGATATCTCACACGCCATGCTTGAGC
AAGCAAAGCAACGCTGCGGTGATGAAGGCATGAGTTACCAGTTAGCGGATGCCGAGCAACTGCCTTTTGCATCTGCTTGT
TTTGACATGGTATTTTCAAGCTTAGCATTACAATGGTGTGAAGATCTGTCGCTGCCGCTGAGCGAAATTCGCCGTGTACT
CAAACCACATGGTCAAGCCTTCCTCTCCACCTTGTTAGACGGTTCGCTGTTTGAACTCGAGCAAGCGTGGCGCAGCGTTG
ATCATCATCGTCATATCAATCAGTTCATTTCCATCAATCAGGTAAAAATTGCGTTAGCGCAAGCCGGATGTTCGCAACAT
CACTTAGACTTAGCGGCAATTACGGTTTGGTATGAAGCTGCCTTTATGCTGATGCGCGATCTAAAAGGGATCGGCGCCAA
TCATGTCAGTGGACGTTCAACGGGGCTAATCAGTCGCCGAACGTTGGCAAAAGTGGAATTGGCCTACCAATCATTTCGTA
ACCAACAGGGTCTTGTGCCTGCCACATATCAGGTTTGTTTAGGGGTTATTCACCGATGA

Upstream 100 bases:

>100_bases
TTCCGGGTTTTGTGGCAACACAAACGCCCATCAAACCTTGGTTGTTGGGCAGCTCTGATTCCGCATTGAGTGCATCCCAC
GAGCTCAAGCAGCAAGGGAT

Downstream 100 bases:

>100_bases
GAAATGCAATTTTTATCGCAGGGACGGATACCGACGTTGGGAAAACAGTCGCTTCGAAAGCGATTCTTCAGGCGCTCGCG
ACACACAATATCGCTACGAT

Product: biotin synthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MGECHSTTHRACRQCAFTYHDNGGAYPSADTPLIGAVKTCDGEGHMSMTATELCVELKDKSAIAQAFGKAAAHYDQHAAF
QRDVGLRLLQKMPSCLKGLRVLDLGCGTGYFSALLRERGAQVVCADISHAMLEQAKQRCGDEGMSYQLADAEQLPFASAC
FDMVFSSLALQWCEDLSLPLSEIRRVLKPHGQAFLSTLLDGSLFELEQAWRSVDHHRHINQFISINQVKIALAQAGCSQH
HLDLAAITVWYEAAFMLMRDLKGIGANHVSGRSTGLISRRTLAKVELAYQSFRNQQGLVPATYQVCLGVIHR

Sequences:

>Translated_312_residues
MGECHSTTHRACRQCAFTYHDNGGAYPSADTPLIGAVKTCDGEGHMSMTATELCVELKDKSAIAQAFGKAAAHYDQHAAF
QRDVGLRLLQKMPSCLKGLRVLDLGCGTGYFSALLRERGAQVVCADISHAMLEQAKQRCGDEGMSYQLADAEQLPFASAC
FDMVFSSLALQWCEDLSLPLSEIRRVLKPHGQAFLSTLLDGSLFELEQAWRSVDHHRHINQFISINQVKIALAQAGCSQH
HLDLAAITVWYEAAFMLMRDLKGIGANHVSGRSTGLISRRTLAKVELAYQSFRNQQGLVPATYQVCLGVIHR
>Mature_311_residues
GECHSTTHRACRQCAFTYHDNGGAYPSADTPLIGAVKTCDGEGHMSMTATELCVELKDKSAIAQAFGKAAAHYDQHAAFQ
RDVGLRLLQKMPSCLKGLRVLDLGCGTGYFSALLRERGAQVVCADISHAMLEQAKQRCGDEGMSYQLADAEQLPFASACF
DMVFSSLALQWCEDLSLPLSEIRRVLKPHGQAFLSTLLDGSLFELEQAWRSVDHHRHINQFISINQVKIALAQAGCSQHH
LDLAAITVWYEAAFMLMRDLKGIGANHVSGRSTGLISRRTLAKVELAYQSFRNQQGLVPATYQVCLGVIHR

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=236, Percent_Identity=32.6271186440678, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI86792933, Length=155, Percent_Identity=32.9032258064516, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786994, Length=241, Percent_Identity=43.5684647302905, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535003, Length=256, Percent_Identity=27.734375, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922210, Length=261, Percent_Identity=30.2681992337165, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 34286; Mature: 34154

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGECHSTTHRACRQCAFTYHDNGGAYPSADTPLIGAVKTCDGEGHMSMTATELCVELKDK
CCCCCHHHHHHHHHHHCEEECCCCCCCCCCCCCEEHEEECCCCCCCHHHHHHHHHHHHHH
SAIAQAFGKAAAHYDQHAAFQRDVGLRLLQKMPSCLKGLRVLDLGCGTGYFSALLRERGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHCCC
QVVCADISHAMLEQAKQRCGDEGMSYQLADAEQLPFASACFDMVFSSLALQWCEDLSLPL
EEEEHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCH
SEIRRVLKPHGQAFLSTLLDGSLFELEQAWRSVDHHRHINQFISINQVKIALAQAGCSQH
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
HLDLAAITVWYEAAFMLMRDLKGIGANHVSGRSTGLISRRTLAKVELAYQSFRNQQGLVP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
ATYQVCLGVIHR
HHHHHHHHHHCC
>Mature Secondary Structure 
GECHSTTHRACRQCAFTYHDNGGAYPSADTPLIGAVKTCDGEGHMSMTATELCVELKDK
CCCCHHHHHHHHHHHCEEECCCCCCCCCCCCCEEHEEECCCCCCCHHHHHHHHHHHHHH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HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]