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The map label for this gene is argD

Identifier: 147673566

GI number: 147673566

Start: 2340402

End: 2341613

Strand: Reverse

Name: argD

Synonym: VC0395_A2195

Alternate gene names: 147673566

Gene position: 2341613-2340402 (Counterclockwise)

Preceding gene: 147673532

Following gene: 229259767

Centisome position: 77.43

GC content: 51.16

Gene sequence:

>1212_bases
ATGACGGTGGAAATGAGTGTAGATCGGAGTTCTTTTGATGAGGTGATGGTGCCTTGTTACAACCCGATGGAGTTTATCCC
AGTAAAAGGTTTTGGTTCACGGATTTGGGATCAGCAGGGTCATGAGTACATTGACTTCGCTGGCGGGATTGCGGTGAGTT
GTCTAGGGCATTGCCACCCAGTGATGGTGCAAGCCTTGACCACCCAAGCCAATAAGCTGTGGCATTTAAGTAACGTAATG
ACCAATGAGCCAGCGTTGCGCTTGGCGAAAAAACTGACTCAAGTGAGTTTTGCCGAAAAGGTCTTTTTTGCCAACTCCGG
CGCGGAAGCCAACGAAGCAGCACTCAAACTGGCGCGTCGTTATGCGGCCGATGTGTATGGTCCTGAGAAATCCGAGATTA
TTGCCTTTAACCAAGGTTTCCACGGTCGTACTTTCTTTACCGTATCGGTCGGTGGTCAAGCGACCTATTCGGATGGTTTT
GGCCCTAAACCGGGTGATATTGTTCATTTGCCTTATAACGATTTGGCTGCACTGCAAGCGCAGATCTCCGATCGCACTTG
TGCTGTGATGATGGAGCCGCTGCAAGGTGAAGGTGGCATTGTTTCTCCGAGTGCTGAATTTGTGCAAGCGGTGCGCGAGT
TGTGTGACAAACACAATGCACTACTGATTTTCGATGAAGTGCAGACGGGTAACGGCCGTACCGGTGATTTCTATGCCTAC
CAAGGGATTGGTGTGACGCCAGATATTCTGGCGACCGCAAAATCTCTCGGTGGCGGTTTCCCAATCGGTGCCATGCTGAC
CACGGCGAAAATTGCTGAGCACATGAAAGTGGGCGTACACGGTTCGACTTATGGCGGTAACCCATTAGCGTGTGCCGTAG
CGGAAGCGGTAGTGGATTTCGTCGCGCAACCAGAAATACTGGCTGGTGTGAAACAGCGTGAGCAGTGGATGCGCGCTGAG
CTAGAGAAAATCAATCAGAAATATCAATTGTTTAAAGAGATCCGCGGTAAAGGTTTGCTACTTGGTGCGGCACTCAACGA
TGAATGGCAAGGCCGTGCGCGTGACATTCTGGTCGCTGCGGGTAAGCAAGGCTTGATGGTGTTGGTGGCCGGGGCGAGCG
TGGTTCGCTTTACGCCATCTCTCATCATCAGCCAACAAGAAATCGAAGAAGGTATGGCTCGCTTAGACAAAGCGATCGCC
ACACTGATGTGA

Upstream 100 bases:

>100_bases
AATGCTGCAAATGCTTTAAGGAAATACATAATCTAACACAGAGCCATTTTGTGGAAGAATCGCTTATCTCTGAGCATGCG
GTATCGAGAGGGAATGGGTA

Downstream 100 bases:

>100_bases
TAGCGAAGGGTTTGCATCGCAAGCCCTGATTGACGAACCTCGGAGGTTCGACGCTATCGCAAACTGCAGGATGACGTGAG
GGGCGAAAGGTTCTCGCCCC

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTVEMSVDRSSFDEVMVPCYNPMEFIPVKGFGSRIWDQQGHEYIDFAGGIAVSCLGHCHPVMVQALTTQANKLWHLSNVM
TNEPALRLAKKLTQVSFAEKVFFANSGAEANEAALKLARRYAADVYGPEKSEIIAFNQGFHGRTFFTVSVGGQATYSDGF
GPKPGDIVHLPYNDLAALQAQISDRTCAVMMEPLQGEGGIVSPSAEFVQAVRELCDKHNALLIFDEVQTGNGRTGDFYAY
QGIGVTPDILATAKSLGGGFPIGAMLTTAKIAEHMKVGVHGSTYGGNPLACAVAEAVVDFVAQPEILAGVKQREQWMRAE
LEKINQKYQLFKEIRGKGLLLGAALNDEWQGRARDILVAAGKQGLMVLVAGASVVRFTPSLIISQQEIEEGMARLDKAIA
TLM

Sequences:

>Translated_403_residues
MTVEMSVDRSSFDEVMVPCYNPMEFIPVKGFGSRIWDQQGHEYIDFAGGIAVSCLGHCHPVMVQALTTQANKLWHLSNVM
TNEPALRLAKKLTQVSFAEKVFFANSGAEANEAALKLARRYAADVYGPEKSEIIAFNQGFHGRTFFTVSVGGQATYSDGF
GPKPGDIVHLPYNDLAALQAQISDRTCAVMMEPLQGEGGIVSPSAEFVQAVRELCDKHNALLIFDEVQTGNGRTGDFYAY
QGIGVTPDILATAKSLGGGFPIGAMLTTAKIAEHMKVGVHGSTYGGNPLACAVAEAVVDFVAQPEILAGVKQREQWMRAE
LEKINQKYQLFKEIRGKGLLLGAALNDEWQGRARDILVAAGKQGLMVLVAGASVVRFTPSLIISQQEIEEGMARLDKAIA
TLM
>Mature_402_residues
TVEMSVDRSSFDEVMVPCYNPMEFIPVKGFGSRIWDQQGHEYIDFAGGIAVSCLGHCHPVMVQALTTQANKLWHLSNVMT
NEPALRLAKKLTQVSFAEKVFFANSGAEANEAALKLARRYAADVYGPEKSEIIAFNQGFHGRTFFTVSVGGQATYSDGFG
PKPGDIVHLPYNDLAALQAQISDRTCAVMMEPLQGEGGIVSPSAEFVQAVRELCDKHNALLIFDEVQTGNGRTGDFYAYQ
GIGVTPDILATAKSLGGGFPIGAMLTTAKIAEHMKVGVHGSTYGGNPLACAVAEAVVDFVAQPEILAGVKQREQWMRAEL
EKINQKYQLFKEIRGKGLLLGAALNDEWQGRARDILVAAGKQGLMVLVAGASVVRFTPSLIISQQEIEEGMARLDKAIAT
LM

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=389, Percent_Identity=36.5038560411311, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI284507298, Length=304, Percent_Identity=38.1578947368421, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI13994255, Length=426, Percent_Identity=27.6995305164319, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI37574042, Length=407, Percent_Identity=27.027027027027, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=26.7469879518072, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.1317829457364, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=407, Percent_Identity=26.044226044226, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI188536080, Length=416, Percent_Identity=22.1153846153846, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI38679950, Length=416, Percent_Identity=22.1153846153846, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI38679946, Length=416, Percent_Identity=22.1153846153846, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=60.1485148514851, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=59.4387755102041, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1789016, Length=387, Percent_Identity=34.8837209302326, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=35.4430379746835, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI145693181, Length=385, Percent_Identity=34.8051948051948, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1786991, Length=316, Percent_Identity=30.379746835443, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786349, Length=292, Percent_Identity=31.1643835616438, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=384, Percent_Identity=33.0729166666667, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=30.0230946882217, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=264, Percent_Identity=32.5757575757576, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=26.4501160092807, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=451, Percent_Identity=25.9423503325942, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71981843, Length=175, Percent_Identity=32, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=393, Percent_Identity=38.676844783715, Blast_Score=269, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6323470, Length=404, Percent_Identity=34.4059405940594, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324386, Length=336, Percent_Identity=29.7619047619048, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=24.5977011494253, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=34.3669250645995, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI161085790, Length=424, Percent_Identity=28.0660377358491, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574759, Length=405, Percent_Identity=28.641975308642, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=28.9099526066351, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281366494, Length=432, Percent_Identity=22.9166666666667, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667139, Length=432, Percent_Identity=22.9166666666667, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667143, Length=432, Percent_Identity=22.9166666666667, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_VIBCH (Q9KNW2)

Other databases:

- EMBL:   AE003852
- PIR:   F82054
- RefSeq:   NP_232246.1
- ProteinModelPortal:   Q9KNW2
- SMR:   Q9KNW2
- GeneID:   2615635
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC2618
- TIGR:   VC_2618
- HOGENOM:   HBG725944
- OMA:   NATFADR
- ProtClustDB:   PRK05093
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR03246
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 43578; Mature: 43446

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 140-140 BINDING 143-143 BINDING 282-282 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEMSVDRSSFDEVMVPCYNPMEFIPVKGFGSRIWDQQGHEYIDFAGGIAVSCLGHCHP
CEEEEECCCCCCCCEECCCCCCCEEEEECCCCCHHHHHCCCCEEECCCCHHHHHHHCHHH
VMVQALTTQANKLWHLSNVMTNEPALRLAKKLTQVSFAEKVFFANSGAEANEAALKLARR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
YAADVYGPEKSEIIAFNQGFHGRTFFTVSVGGQATYSDGFGPKPGDIVHLPYNDLAALQA
HHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCEEECCCCCCCCCCEEECCCHHHHHHHH
QISDRTCAVMMEPLQGEGGIVSPSAEFVQAVRELCDKHNALLIFDEVQTGNGRTGDFYAY
HHCCCEEEEEECCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEE
QGIGVTPDILATAKSLGGGFPIGAMLTTAKIAEHMKVGVHGSTYGGNPLACAVAEAVVDF
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
VAQPEILAGVKQREQWMRAELEKINQKYQLFKEIRGKGLLLGAALNDEWQGRARDILVAA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEC
GKQGLMVLVAGASVVRFTPSLIISQQEIEEGMARLDKAIATLM
CCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVEMSVDRSSFDEVMVPCYNPMEFIPVKGFGSRIWDQQGHEYIDFAGGIAVSCLGHCHP
EEEEECCCCCCCCEECCCCCCCEEEEECCCCCHHHHHCCCCEEECCCCHHHHHHHCHHH
VMVQALTTQANKLWHLSNVMTNEPALRLAKKLTQVSFAEKVFFANSGAEANEAALKLARR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
YAADVYGPEKSEIIAFNQGFHGRTFFTVSVGGQATYSDGFGPKPGDIVHLPYNDLAALQA
HHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCEEECCCCCCCCCCEEECCCHHHHHHHH
QISDRTCAVMMEPLQGEGGIVSPSAEFVQAVRELCDKHNALLIFDEVQTGNGRTGDFYAY
HHCCCEEEEEECCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEE
QGIGVTPDILATAKSLGGGFPIGAMLTTAKIAEHMKVGVHGSTYGGNPLACAVAEAVVDF
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
VAQPEILAGVKQREQWMRAELEKINQKYQLFKEIRGKGLLLGAALNDEWQGRARDILVAA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEC
GKQGLMVLVAGASVVRFTPSLIISQQEIEEGMARLDKAIATLM
CCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301