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The map label for this gene is envZ [H]

Identifier: 147673138

GI number: 147673138

Start: 2440932

End: 2442248

Strand: Reverse

Name: envZ [H]

Synonym: VC0395_A2285

Alternate gene names: 147673138

Gene position: 2442248-2440932 (Counterclockwise)

Preceding gene: 147673571

Following gene: 147674537

Centisome position: 80.76

GC content: 50.57

Gene sequence:

>1317_bases
ATGCGAATTCGCAGTTCATTTACCCAATCGATCCTGCTGTTTTTCTCTCTGTTGATCGCCAGTCAAATCTATTCTTACTA
CGCGGTTTTTAACTATGCGTTGCTGCCGAGTTTGCAGCAATTCAACAAAATTCTTGCCCATGAAATCAGCTTGATGCTCG
ATGACACCAGTAATCCGAATGTCAGTTCCGAAATGGATGCGTTGCTCAAAAGGCGTGTGCTTGAGCAATTAGGGGTGACG
ATTCATAGTAACGACAGCCCCGAAGCGGTCGAATATCAACACGCGATCAGTTTGGATTTGATGAGCGAAGAGATGAGTAG
TGAGCTGGGTTCACCCACAGAAGTGCGCATGGCGTTGGGCGAAGAGAGCTACATCCTGTGGATGAAGATCGATTCTCTGC
CCGGCCAGTTGCTGCGTATTCCACTCTCAGAGCTGCAGGAAGAAGATTTCGCGCCGCTGTTTCGTAACAGCATTATTATG
GCGCTACTGATTGTAATTGGTGGCTGGCTGTTTATTCGTCTGCAAAACCGTCCACTGATTGCCTTGGAAAAAGCCGCCAA
AATGGTAGGTCGTGGAGAAACGCCACCACATCTACCTGAGCAAGGCACGCTTGAAATCCGCTCGGTAACGCGCGCGTTTA
ATCGAATGTCGAAAGGCATTCAAGCACTGGAAGAAGATCGCGCGCTGTTGATGGCGGGGATCAGTCATGATATCCGCACG
CCCTTGACTCGAATTCGCTTGGCAACCGAGATGATGTCACCAGAAGACAGCTATCTTGCTGAGAGCATCATCAGCGATAC
CGAAGAGTGTAACCAGATCATCAGCCAATTTATGGATTACCTGAAACCCGTCAATCGTGAAGCGTTTGAAGCGGTGGATT
TGAATGATATTGCCAGCGATGTGGCAAGCTCTGAAGGGGGCTACGAAGTGCAGATTGAAACCGATCTGCAAGCGGAACTC
GCGCCCGCTTTTGGTAACCCGATTGCGATTAAGCGTTCACTGAGTAACTTGGTAGTGAATGCGCTGCGCTACGGCAACGG
TTGGGTCAAAGTGAGTAGCGGCATGACGGCCGATAAGAAGCTAGTCTGGCTGTCTGTGGAAGACAATGGGCCGGGTATCG
ATCCAAGCCAAGTGAATAAAGTGTTTGAGCCTTTTACTCGTGGGGATACCGCGCGGGGCAGTGAAGGGACGGGCTTAGGG
CTGGCGATTGTGAAGCGGATTGTCAGCCAGCATCATGGCGCGGTGTCGGTGAGCAACCGTACTCAAGGTGGTCTGCGAGC
ACAAATCAGTTTCCCAACTAAGCAGCAAAAGGGCTAA

Upstream 100 bases:

>100_bases
TGTTTGTTCCTGATGGTAAAGCCGCCAACTAACTTCTTTTAGGCACGCCGGGCAAGGGCGTCCTCGCTCCGCGCGTGCCC
TTGCTACATTTAGGTGCCTT

Downstream 100 bases:

>100_bases
CCTAAGTTAGCCCTGATTGAACCGTTAGTTTGACTCTTGCGCCGTTTCGGTAACCGAAGCGGCGTTTTCATCTCGGCGTA
CTTCTGGCAGCAGCAGGTTA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRIRSSFTQSILLFFSLLIASQIYSYYAVFNYALLPSLQQFNKILAHEISLMLDDTSNPNVSSEMDALLKRRVLEQLGVT
IHSNDSPEAVEYQHAISLDLMSEEMSSELGSPTEVRMALGEESYILWMKIDSLPGQLLRIPLSELQEEDFAPLFRNSIIM
ALLIVIGGWLFIRLQNRPLIALEKAAKMVGRGETPPHLPEQGTLEIRSVTRAFNRMSKGIQALEEDRALLMAGISHDIRT
PLTRIRLATEMMSPEDSYLAESIISDTEECNQIISQFMDYLKPVNREAFEAVDLNDIASDVASSEGGYEVQIETDLQAEL
APAFGNPIAIKRSLSNLVVNALRYGNGWVKVSSGMTADKKLVWLSVEDNGPGIDPSQVNKVFEPFTRGDTARGSEGTGLG
LAIVKRIVSQHHGAVSVSNRTQGGLRAQISFPTKQQKG

Sequences:

>Translated_438_residues
MRIRSSFTQSILLFFSLLIASQIYSYYAVFNYALLPSLQQFNKILAHEISLMLDDTSNPNVSSEMDALLKRRVLEQLGVT
IHSNDSPEAVEYQHAISLDLMSEEMSSELGSPTEVRMALGEESYILWMKIDSLPGQLLRIPLSELQEEDFAPLFRNSIIM
ALLIVIGGWLFIRLQNRPLIALEKAAKMVGRGETPPHLPEQGTLEIRSVTRAFNRMSKGIQALEEDRALLMAGISHDIRT
PLTRIRLATEMMSPEDSYLAESIISDTEECNQIISQFMDYLKPVNREAFEAVDLNDIASDVASSEGGYEVQIETDLQAEL
APAFGNPIAIKRSLSNLVVNALRYGNGWVKVSSGMTADKKLVWLSVEDNGPGIDPSQVNKVFEPFTRGDTARGSEGTGLG
LAIVKRIVSQHHGAVSVSNRTQGGLRAQISFPTKQQKG
>Mature_438_residues
MRIRSSFTQSILLFFSLLIASQIYSYYAVFNYALLPSLQQFNKILAHEISLMLDDTSNPNVSSEMDALLKRRVLEQLGVT
IHSNDSPEAVEYQHAISLDLMSEEMSSELGSPTEVRMALGEESYILWMKIDSLPGQLLRIPLSELQEEDFAPLFRNSIIM
ALLIVIGGWLFIRLQNRPLIALEKAAKMVGRGETPPHLPEQGTLEIRSVTRAFNRMSKGIQALEEDRALLMAGISHDIRT
PLTRIRLATEMMSPEDSYLAESIISDTEECNQIISQFMDYLKPVNREAFEAVDLNDIASDVASSEGGYEVQIETDLQAEL
APAFGNPIAIKRSLSNLVVNALRYGNGWVKVSSGMTADKKLVWLSVEDNGPGIDPSQVNKVFEPFTRGDTARGSEGTGLG
LAIVKRIVSQHHGAVSVSNRTQGGLRAQISFPTKQQKG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=439, Percent_Identity=47.8359908883827, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=32.2097378277154, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787894, Length=275, Percent_Identity=31.2727272727273, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786783, Length=295, Percent_Identity=27.7966101694915, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=26.4214046822742, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=29.2237442922374, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.9661016949153, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=205, Percent_Identity=28.780487804878, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082128, Length=296, Percent_Identity=23.6486486486486, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=28.5106382978723, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081816, Length=214, Percent_Identity=28.5046728971963, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=27.3469387755102, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=291, Percent_Identity=25.085910652921, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789403, Length=243, Percent_Identity=26.7489711934156, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=292, Percent_Identity=26.027397260274, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=24.4541484716157, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789149, Length=215, Percent_Identity=23.7209302325581, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790300, Length=206, Percent_Identity=25.2427184466019, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48531; Mature: 48531

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRSSFTQSILLFFSLLIASQIYSYYAVFNYALLPSLQQFNKILAHEISLMLDDTSNPN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
VSSEMDALLKRRVLEQLGVTIHSNDSPEAVEYQHAISLDLMSEEMSSELGSPTEVRMALG
CHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEC
EESYILWMKIDSLPGQLLRIPLSELQEEDFAPLFRNSIIMALLIVIGGWLFIRLQNRPLI
CCCEEEEEEECCCCCHHHCCCHHHHCHHCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEE
ALEKAAKMVGRGETPPHLPEQGTLEIRSVTRAFNRMSKGIQALEEDRALLMAGISHDIRT
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
PLTRIRLATEMMSPEDSYLAESIISDTEECNQIISQFMDYLKPVNREAFEAVDLNDIASD
HHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHH
VASSEGGYEVQIETDLQAELAPAFGNPIAIKRSLSNLVVNALRYGNGWVKVSSGMTADKK
HHCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCE
LVWLSVEDNGPGIDPSQVNKVFEPFTRGDTARGSEGTGLGLAIVKRIVSQHHGAVSVSNR
EEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
TQGGLRAQISFPTKQQKG
CCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRIRSSFTQSILLFFSLLIASQIYSYYAVFNYALLPSLQQFNKILAHEISLMLDDTSNPN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
VSSEMDALLKRRVLEQLGVTIHSNDSPEAVEYQHAISLDLMSEEMSSELGSPTEVRMALG
CHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEC
EESYILWMKIDSLPGQLLRIPLSELQEEDFAPLFRNSIIMALLIVIGGWLFIRLQNRPLI
CCCEEEEEEECCCCCHHHCCCHHHHCHHCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEE
ALEKAAKMVGRGETPPHLPEQGTLEIRSVTRAFNRMSKGIQALEEDRALLMAGISHDIRT
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
PLTRIRLATEMMSPEDSYLAESIISDTEECNQIISQFMDYLKPVNREAFEAVDLNDIASD
HHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHH
VASSEGGYEVQIETDLQAELAPAFGNPIAIKRSLSNLVVNALRYGNGWVKVSSGMTADKK
HHCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCE
LVWLSVEDNGPGIDPSQVNKVFEPFTRGDTARGSEGTGLGLAIVKRIVSQHHGAVSVSNR
EEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
TQGGLRAQISFPTKQQKG
CCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]