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The map label for this gene is lig [H]

Identifier: 146343507

GI number: 146343507

Start: 6999642

End: 7001510

Strand: Direct

Name: lig [H]

Synonym: BRADO6739

Alternate gene names: 146343507

Gene position: 6999642-7001510 (Clockwise)

Preceding gene: 146343506

Following gene: 146343508

Centisome position: 93.87

GC content: 67.2

Gene sequence:

>1869_bases
ATGAACCGCTTCGCCGAGCTGCTCGACCGCCTCGCCTATGAGCCCGGCCGCAACAACAAGCTGCGCCTGCTGACCTCGTA
TTTCCGCGAGGTCGAGGACCCCGACCGCGGCTACGCACTGGGCGCGCTGACCGGCGCGCTGTCGTTCAAGCACGCCAAGC
CGGCGCTGATCCGCGACCTCATCGCCGCCCGCGCGGATCCGGTGCTGTTCGCCTTGTCGTATGATTATGTCGGCGACCTC
TCCGAGACCGTCGCGCTGATGTGGCCGAAGGGCGGGTCTCAGCAGCAGCACGTTTCCGGGCACCCCCCTCCCCAACCCTT
CCCCACAAGGGGGGAGGGAGCCGAGTTGCGTGCTGCGCTCTCAGCTCCCCCGGCATCGACGAGGGACTCATCGGACGATC
TCGTCGTTACAAACACCGCTCTCACCATTCCCTCCCCCCTTATGGGAAAGGGTCAGGGAGGGGGGTGTCCCACGGGTGGT
CTCTCGACTCAGCTCCCGCCCGGCCACAACCACCCGCCGCCACCGACGCTCACCGAGGTCGTCACCACGCTCCGCACCCT
CGGCAAGACCGAGATGCCGAAGCAGCTGGCGCGCTGGCTGGACGAGCTCGACGAGACCGGACGCTGGGCGCTGCTGAAGC
TGGTCACCGGGAGCTTACGCATCGGCATCTCCGCGCGCCTCGCAAAGACCGCGGCCGCCGCGCTCGGCCACAAGGATCCT
CATGACGTCGAGCTGATCTGGCCGGGCCTGTCGCCGCCCTATCTCGATTTGTTTGCCTGGCTCGAAGGCCGCGGCGACAA
GCCGGTCAATCGCGACCCCGCGCCGTTCCGGCCCGTCATGCTGGCGCACGCCGTCGAGGACGGCGACTTCGCCAACATGG
CGGCCGCCGACTACATCGCCGAATGGAAATGGGACGGCATCCGCGTGCAGGCGGTCAGCGGCCGCGAGGCCGATGGCCGC
ATTGTGACGCGGCTGTATTCGCGCAGCGGCGAGGACATCACCGCGAGCTTCCCTGATCTCTTGCCGTCGCTGCATTTGCC
CGGCGCGCTCGACGGCGAACTGCTGGTGGTGCGCGACAGGCGCGTGCAGAGTTTCAACGTATTGCAGCAGCGGCTGAACC
GCAAGGCGGTGTCGCCGAAGCTGATGAAGGAGTACCCGATCCATCTGCGCGCCTACGACCTGCTCGGCGACGAGGACCAT
GATCTGCGCGAGCTGCCGTTCGAGCAGCGGCGCAAGAGGCTGGAAGGCTTCATCAAGCGTCTCGACGAGCCGCGTGTCGA
TTTGTCGCCGACCATCGCCTTTGCGAGCTGGGACGAGCTGAAGGCCGCGCGCGCCGATCCGGCCTCGGCCGGCGCCGGCG
ACGACGCGGAGGCAGTCGAAGGCGTCATGCTGAAGCGGCGCGATGCGCTGTATCTGCCCGGCCGGCCGAAGGGCCAATGG
TGGAAGTGGAAGCACGATCCTCATATCATCGACGCCGTGCTGATGTATGCGCAGCGCGGCCACGGCAAGCGCTCGTCCTA
TTACTCCGACTACACATTCGGCGTCTGGACATCGGGCGAGGGAGGCGATCAGCTGGTGCCGGTCGGCAAGGCCTATTTCG
GCTTCACCGACGAGGAGCTCTTGCAGATCGACCGCTTCGTCCGCCGCAACACCACGGAGAAGTTCGGCCCCGTCCGTCAC
GTCGTGCACGAGCCCGAGCAAGGCCTGGTGCTGGAGGTCGCCTTCGAGGGCCTGCAGAAATCGCCGCGGCACAAATCCGG
TGTCGCCATGCGCTTCCCGCGCATCAACCGCCTGCGCTGGGACAAGCCACCACGCGACGCCGACCGGCTGGAGACGCTGG
AGCGGATGCTGAAGAGCGAGACGGGGTGA

Upstream 100 bases:

>100_bases
ATTGGTGTCAGACCAAGGGGCTCACGGCGCGGCCTCTCGATCTCGTCGGCTACGGCGACGAGGAGGAGAGCGAGGTGGTG
GCGTCGGAGGGGGCCGAGGC

Downstream 100 bases:

>100_bases
GGGTTTGATTGGGATGCTGAACACCCAAATTGGCGAGACCCCGCATGGGCCACAAAGTCGCTCGTCATGCCCGGGCTTGA
CCCGGGCATCCATCGCCTCG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MNRFAELLDRLAYEPGRNNKLRLLTSYFREVEDPDRGYALGALTGALSFKHAKPALIRDLIAARADPVLFALSYDYVGDL
SETVALMWPKGGSQQQHVSGHPPPQPFPTRGEGAELRAALSAPPASTRDSSDDLVVTNTALTIPSPLMGKGQGGGCPTGG
LSTQLPPGHNHPPPPTLTEVVTTLRTLGKTEMPKQLARWLDELDETGRWALLKLVTGSLRIGISARLAKTAAAALGHKDP
HDVELIWPGLSPPYLDLFAWLEGRGDKPVNRDPAPFRPVMLAHAVEDGDFANMAAADYIAEWKWDGIRVQAVSGREADGR
IVTRLYSRSGEDITASFPDLLPSLHLPGALDGELLVVRDRRVQSFNVLQQRLNRKAVSPKLMKEYPIHLRAYDLLGDEDH
DLRELPFEQRRKRLEGFIKRLDEPRVDLSPTIAFASWDELKAARADPASAGAGDDAEAVEGVMLKRRDALYLPGRPKGQW
WKWKHDPHIIDAVLMYAQRGHGKRSSYYSDYTFGVWTSGEGGDQLVPVGKAYFGFTDEELLQIDRFVRRNTTEKFGPVRH
VVHEPEQGLVLEVAFEGLQKSPRHKSGVAMRFPRINRLRWDKPPRDADRLETLERMLKSETG

Sequences:

>Translated_622_residues
MNRFAELLDRLAYEPGRNNKLRLLTSYFREVEDPDRGYALGALTGALSFKHAKPALIRDLIAARADPVLFALSYDYVGDL
SETVALMWPKGGSQQQHVSGHPPPQPFPTRGEGAELRAALSAPPASTRDSSDDLVVTNTALTIPSPLMGKGQGGGCPTGG
LSTQLPPGHNHPPPPTLTEVVTTLRTLGKTEMPKQLARWLDELDETGRWALLKLVTGSLRIGISARLAKTAAAALGHKDP
HDVELIWPGLSPPYLDLFAWLEGRGDKPVNRDPAPFRPVMLAHAVEDGDFANMAAADYIAEWKWDGIRVQAVSGREADGR
IVTRLYSRSGEDITASFPDLLPSLHLPGALDGELLVVRDRRVQSFNVLQQRLNRKAVSPKLMKEYPIHLRAYDLLGDEDH
DLRELPFEQRRKRLEGFIKRLDEPRVDLSPTIAFASWDELKAARADPASAGAGDDAEAVEGVMLKRRDALYLPGRPKGQW
WKWKHDPHIIDAVLMYAQRGHGKRSSYYSDYTFGVWTSGEGGDQLVPVGKAYFGFTDEELLQIDRFVRRNTTEKFGPVRH
VVHEPEQGLVLEVAFEGLQKSPRHKSGVAMRFPRINRLRWDKPPRDADRLETLERMLKSETG
>Mature_622_residues
MNRFAELLDRLAYEPGRNNKLRLLTSYFREVEDPDRGYALGALTGALSFKHAKPALIRDLIAARADPVLFALSYDYVGDL
SETVALMWPKGGSQQQHVSGHPPPQPFPTRGEGAELRAALSAPPASTRDSSDDLVVTNTALTIPSPLMGKGQGGGCPTGG
LSTQLPPGHNHPPPPTLTEVVTTLRTLGKTEMPKQLARWLDELDETGRWALLKLVTGSLRIGISARLAKTAAAALGHKDP
HDVELIWPGLSPPYLDLFAWLEGRGDKPVNRDPAPFRPVMLAHAVEDGDFANMAAADYIAEWKWDGIRVQAVSGREADGR
IVTRLYSRSGEDITASFPDLLPSLHLPGALDGELLVVRDRRVQSFNVLQQRLNRKAVSPKLMKEYPIHLRAYDLLGDEDH
DLRELPFEQRRKRLEGFIKRLDEPRVDLSPTIAFASWDELKAARADPASAGAGDDAEAVEGVMLKRRDALYLPGRPKGQW
WKWKHDPHIIDAVLMYAQRGHGKRSSYYSDYTFGVWTSGEGGDQLVPVGKAYFGFTDEELLQIDRFVRRNTTEKFGPVRH
VVHEPEQGLVLEVAFEGLQKSPRHKSGVAMRFPRINRLRWDKPPRDADRLETLERMLKSETG

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=369, Percent_Identity=27.10027100271, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 69275; Mature: 69275

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFAELLDRLAYEPGRNNKLRLLTSYFREVEDPDRGYALGALTGALSFKHAKPALIRDL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCHHHHHHH
IAARADPVLFALSYDYVGDLSETVALMWPKGGSQQQHVSGHPPPQPFPTRGEGAELRAAL
HHHCCCCEEEEEECHHHCCCHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEC
SAPPASTRDSSDDLVVTNTALTIPSPLMGKGQGGGCPTGGLSTQLPPGHNHPPPPTLTEV
CCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VTTLRTLGKTEMPKQLARWLDELDETGRWALLKLVTGSLRIGISARLAKTAAAALGHKDP
HHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEHHHHCCCEECHHHHHHHHHHHHHCCCCC
HDVELIWPGLSPPYLDLFAWLEGRGDKPVNRDPAPFRPVMLAHAVEDGDFANMAAADYIA
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
EWKWDGIRVQAVSGREADGRIVTRLYSRSGEDITASFPDLLPSLHLPGALDGELLVVRDR
HCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEECCCHHHHHCCCCCCCCCCCEEEEECC
RVQSFNVLQQRLNRKAVSPKLMKEYPIHLRAYDLLGDEDHDLRELPFEQRRKRLEGFIKR
CHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHH
LDEPRVDLSPTIAFASWDELKAARADPASAGAGDDAEAVEGVMLKRRDALYLPGRPKGQW
HCCCCCCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCC
WKWKHDPHIIDAVLMYAQRGHGKRSSYYSDYTFGVWTSGEGGDQLVPVGKAYFGFTDEEL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEECCHHHCCCCHHHH
LQIDRFVRRNTTEKFGPVRHVVHEPEQGLVLEVAFEGLQKSPRHKSGVAMRFPRINRLRW
HHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEHEEHHHHHCCCCCCCCCEEECCCCCCCCC
DKPPRDADRLETLERMLKSETG
CCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRFAELLDRLAYEPGRNNKLRLLTSYFREVEDPDRGYALGALTGALSFKHAKPALIRDL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCHHHHHHH
IAARADPVLFALSYDYVGDLSETVALMWPKGGSQQQHVSGHPPPQPFPTRGEGAELRAAL
HHHCCCCEEEEEECHHHCCCHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEC
SAPPASTRDSSDDLVVTNTALTIPSPLMGKGQGGGCPTGGLSTQLPPGHNHPPPPTLTEV
CCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VTTLRTLGKTEMPKQLARWLDELDETGRWALLKLVTGSLRIGISARLAKTAAAALGHKDP
HHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEHHHHCCCEECHHHHHHHHHHHHHCCCCC
HDVELIWPGLSPPYLDLFAWLEGRGDKPVNRDPAPFRPVMLAHAVEDGDFANMAAADYIA
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
EWKWDGIRVQAVSGREADGRIVTRLYSRSGEDITASFPDLLPSLHLPGALDGELLVVRDR
HCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEECCCHHHHHCCCCCCCCCCCEEEEECC
RVQSFNVLQQRLNRKAVSPKLMKEYPIHLRAYDLLGDEDHDLRELPFEQRRKRLEGFIKR
CHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHH
LDEPRVDLSPTIAFASWDELKAARADPASAGAGDDAEAVEGVMLKRRDALYLPGRPKGQW
HCCCCCCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCC
WKWKHDPHIIDAVLMYAQRGHGKRSSYYSDYTFGVWTSGEGGDQLVPVGKAYFGFTDEEL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEECCHHHCCCCHHHH
LQIDRFVRRNTTEKFGPVRHVVHEPEQGLVLEVAFEGLQKSPRHKSGVAMRFPRINRLRW
HHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEHEEHHHHHCCCCCCCCCEEECCCCCCCCC
DKPPRDADRLETLERMLKSETG
CCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA