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The map label for this gene is atpB [H]

Identifier: 146343457

GI number: 146343457

Start: 6949781

End: 6950524

Strand: Direct

Name: atpB [H]

Synonym: BRADO6686

Alternate gene names: 146343457

Gene position: 6949781-6950524 (Clockwise)

Preceding gene: 146343456

Following gene: 146343458

Centisome position: 93.2

GC content: 59.68

Gene sequence:

>744_bases
ATGATCGATCCGATCGAACAATTCCATCTCAACAAGATCTTCACGATCGGCCACATCGGCAATCAGGAGATCGCCTTCAC
CACCTCCAGCGCCTACATGCTGCTCGCGGTCGTGCTGATCGCGGCCATGATGCTCGGCGCCGGGCGCGCGCTCGTTCCGG
GCCGGTTCCAGTCGGTGGTCGAGCTGGCCTACGAATTCGTCGCCAACACCATTAGAACAAGCGCCGGCTCGCACGGCATG
ACGTTCTTTCCGCTGGTGTTCTCGCTGTTCATGTTCATCTTCGTCTCGAACATCGTCGGCATCATCCCCTACACCTTCAC
CGTCTCCAGCCACATCATCGTCACCTTCTCGCTGGCGCTTTTGGTGTTCCTGACGGTCATCATCTACGGCTTCTACAAGA
ACGGCCTGAAGTTCTTTAAGCTGTTCGTGCCCTCCGGCATCCCCGCGGTGATCCTGCCGCTGGTGGTCATCATTGAAATC
ATCTCCTTCTTCTCCCGCCCGATCTCGCACAGCGTCCGTCTGTTCGCCAACATGCTGGCTGGACACGTCACGCTGAAGGT
GTTCGCGAGCTTCGTGACCATGCTCGGCGCGCTCGGCTTCGTCGGCAAGGTCGGCGCGCTGCTGCCGCTCGGCCTCACGG
TCGCCCTGACCGGCCTCGAGCTGATGGTCGCGTTCCTCCAGGCCTACGTCTTCACCATCCTCACCTGCATCTATCTCAAC
GATGCTATCCATCCGGGTCACTGA

Upstream 100 bases:

>100_bases
TCCCGCCAATGAGACGTCAGCGGAACATGTCAGCGCGGAAGACCAACGAGTGAATTGCAAAGCGCCGGCGTGGCCGGTGA
ACAACTGAGACGCCACGCGG

Downstream 100 bases:

>100_bases
TCCGGCCTCTCTACCAAACCTCTCAAAGGAGTTCGTCATGGATCCGGTTGCAGCGAAGTACATTGGCGCGGGCATTGCCT
GCATCGGCATGGGTGGCGCG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a 1; F-ATPase subunit 6 1 [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MIDPIEQFHLNKIFTIGHIGNQEIAFTTSSAYMLLAVVLIAAMMLGAGRALVPGRFQSVVELAYEFVANTIRTSAGSHGM
TFFPLVFSLFMFIFVSNIVGIIPYTFTVSSHIIVTFSLALLVFLTVIIYGFYKNGLKFFKLFVPSGIPAVILPLVVIIEI
ISFFSRPISHSVRLFANMLAGHVTLKVFASFVTMLGALGFVGKVGALLPLGLTVALTGLELMVAFLQAYVFTILTCIYLN
DAIHPGH

Sequences:

>Translated_247_residues
MIDPIEQFHLNKIFTIGHIGNQEIAFTTSSAYMLLAVVLIAAMMLGAGRALVPGRFQSVVELAYEFVANTIRTSAGSHGM
TFFPLVFSLFMFIFVSNIVGIIPYTFTVSSHIIVTFSLALLVFLTVIIYGFYKNGLKFFKLFVPSGIPAVILPLVVIIEI
ISFFSRPISHSVRLFANMLAGHVTLKVFASFVTMLGALGFVGKVGALLPLGLTVALTGLELMVAFLQAYVFTILTCIYLN
DAIHPGH
>Mature_247_residues
MIDPIEQFHLNKIFTIGHIGNQEIAFTTSSAYMLLAVVLIAAMMLGAGRALVPGRFQSVVELAYEFVANTIRTSAGSHGM
TFFPLVFSLFMFIFVSNIVGIIPYTFTVSSHIIVTFSLALLVFLTVIIYGFYKNGLKFFKLFVPSGIPAVILPLVVIIEI
ISFFSRPISHSVRLFANMLAGHVTLKVFASFVTMLGALGFVGKVGALLPLGLTVALTGLELMVAFLQAYVFTILTCIYLN
DAIHPGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=205, Percent_Identity=28.2926829268293, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1790176, Length=209, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6226527, Length=247, Percent_Identity=33.1983805668016, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 26934; Mature: 26934

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCC
>Mature Secondary Structure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CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA