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The map label for this gene is hemA [H]

Identifier: 146343443

GI number: 146343443

Start: 6932074

End: 6933303

Strand: Direct

Name: hemA [H]

Synonym: BRADO6672

Alternate gene names: 146343443

Gene position: 6932074-6933303 (Clockwise)

Preceding gene: 146343442

Following gene: 146343444

Centisome position: 92.97

GC content: 66.83

Gene sequence:

>1230_bases
ATGGACTACAGCCAATATTTCAGTGCCGCTCTGGGTCGTCTGCATGACGAGCGCCGCTATCGGGTTTTCGCCGATCTCGA
ACGCATCGCCGGCCGGTTCCCGCACGCCACCTGGCACTCGCCGAACGGTCCGCGCAACGTCGTGATCTGGTGCTCCAACG
ACTATCTCGGCATGGGCCAGCACCCGAAGGTGGTCGGCGCAATGGTCGAGACCGCGACCCGCGTCGGCACCGGCGCCGGC
GGCACCCGCAACATCGCCGGCACCCACCATCCCCTGGTGCAACTGGAAGCCGAGCTCGCCGATCTGCACGGCAAGGAAGC
GGCGCTGCTGTTCACCTCCGGCTACGTCTCGAACCAGACCGGCATCGCCACGCTCGCCAAGCTGATCCCGGACTGCCTGA
TCCTGTCGGATGCGCTCAATCACAATTCGATGATCGAGGGCGTGCGCCAGTCCGGCTGCGAGCGCCAGATCTGGCGCCAC
AACGACCTTGCCCATCTCGAGCAGTTGCTGATCGCGGCCGGCCCGAGCCGGCCGAAGCTGATCGCCTGCGAGAGCCTGTA
TTCGATGGACGGCGACGTCGCGCCGCTGGCCGCGATCTGCGATCTCGCCGAGCGCTACAATGCGATGACCTATGTCGACG
AGGTGCATGCGGTCGGCATGTACGGCGCGCGAGGCGGCGGCATCGCCGAGCGCGACGGCGTCATGCACCGCATCGACATT
CTCGAAGGCACGCTGGCGAAAGCGTTCGGCTGTCTCGGCGGCTACATCGCAGCCAAGGGCGAGATCATCGACGCCGTGCG
CTCCTACGCGCCGGGTTTCATCTTCACGACGGCGCTGCCGCCGCCGATCTGCTCGGCCGCCACCGCCGCGATCAAGCACC
TGAAATCGTCGAGCTGGGAGCGCGAGCGCCACCAGGACCGCGCTGCCCGCGTCAAGGCGATCCTCAACGCCGCTGGCCTG
CCTGTCATGGACAACGACACCCACATCGTGCCGCTGTTCGTCGGCGATCCCGAGAAGTGCAAGCAGGCCTCCGACCTGCT
GCTCGAAGAGCACGGCATCTACATCCAGCCGATCAACTACCCGACGGTCGCCAAGGGCACCGAGCGCCTGCGCATCACGC
CCTCGCCCTATCACGACGACGGCCTGATCGACCGCCTGGCGGAGGCCCTGCTGCAGGTCTGGGAACGGCTGGGATTGGCG
CTGCACAAGAAGCCGCTGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
GACAGCCGCTCTGGAAACGCTCTAAGAAGGCCTTAAGCCCCCGTCGCTTAGAGGGTCCGCTCCAGGCGCTGCGCTGCAGC
GCAGCACGTCAGGTTCCGTG

Downstream 100 bases:

>100_bases
CCTTCGTAGCCCGGGTAAGCGCAGCGACACCCGGGTTCACCGAGACGGCACGTGATACCCCGGATATCGCTGCGCTCATC
CGGGCTACGGCCCCTCCGCT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MDYSQYFSAALGRLHDERRYRVFADLERIAGRFPHATWHSPNGPRNVVIWCSNDYLGMGQHPKVVGAMVETATRVGTGAG
GTRNIAGTHHPLVQLEAELADLHGKEAALLFTSGYVSNQTGIATLAKLIPDCLILSDALNHNSMIEGVRQSGCERQIWRH
NDLAHLEQLLIAAGPSRPKLIACESLYSMDGDVAPLAAICDLAERYNAMTYVDEVHAVGMYGARGGGIAERDGVMHRIDI
LEGTLAKAFGCLGGYIAAKGEIIDAVRSYAPGFIFTTALPPPICSAATAAIKHLKSSSWERERHQDRAARVKAILNAAGL
PVMDNDTHIVPLFVGDPEKCKQASDLLLEEHGIYIQPINYPTVAKGTERLRITPSPYHDDGLIDRLAEALLQVWERLGLA
LHKKPLAAE

Sequences:

>Translated_409_residues
MDYSQYFSAALGRLHDERRYRVFADLERIAGRFPHATWHSPNGPRNVVIWCSNDYLGMGQHPKVVGAMVETATRVGTGAG
GTRNIAGTHHPLVQLEAELADLHGKEAALLFTSGYVSNQTGIATLAKLIPDCLILSDALNHNSMIEGVRQSGCERQIWRH
NDLAHLEQLLIAAGPSRPKLIACESLYSMDGDVAPLAAICDLAERYNAMTYVDEVHAVGMYGARGGGIAERDGVMHRIDI
LEGTLAKAFGCLGGYIAAKGEIIDAVRSYAPGFIFTTALPPPICSAATAAIKHLKSSSWERERHQDRAARVKAILNAAGL
PVMDNDTHIVPLFVGDPEKCKQASDLLLEEHGIYIQPINYPTVAKGTERLRITPSPYHDDGLIDRLAEALLQVWERLGLA
LHKKPLAAE
>Mature_409_residues
MDYSQYFSAALGRLHDERRYRVFADLERIAGRFPHATWHSPNGPRNVVIWCSNDYLGMGQHPKVVGAMVETATRVGTGAG
GTRNIAGTHHPLVQLEAELADLHGKEAALLFTSGYVSNQTGIATLAKLIPDCLILSDALNHNSMIEGVRQSGCERQIWRH
NDLAHLEQLLIAAGPSRPKLIACESLYSMDGDVAPLAAICDLAERYNAMTYVDEVHAVGMYGARGGGIAERDGVMHRIDI
LEGTLAKAFGCLGGYIAAKGEIIDAVRSYAPGFIFTTALPPPICSAATAAIKHLKSSSWERERHQDRAARVKAILNAAGL
PVMDNDTHIVPLFVGDPEKCKQASDLLLEEHGIYIQPINYPTVAKGTERLRITPSPYHDDGLIDRLAEALLQVWERLGLA
LHKKPLAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=412, Percent_Identity=48.3009708737864, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI83977440, Length=412, Percent_Identity=48.3009708737864, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI83977444, Length=412, Percent_Identity=48.3009708737864, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4502025, Length=405, Percent_Identity=49.3827160493827, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI40316939, Length=405, Percent_Identity=49.3827160493827, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=35.632183908046, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=35.632183908046, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI119220554, Length=403, Percent_Identity=29.2803970223325, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4758668, Length=403, Percent_Identity=29.2803970223325, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI5454084, Length=256, Percent_Identity=26.5625, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1790046, Length=376, Percent_Identity=35.3723404255319, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=32.7586206896552, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=356, Percent_Identity=35.9550561797753, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=381, Percent_Identity=30.4461942257218, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=373, Percent_Identity=28.9544235924933, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=373, Percent_Identity=28.9544235924933, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=251, Percent_Identity=27.4900398406374, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=251, Percent_Identity=27.4900398406374, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=421, Percent_Identity=46.0807600950119, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=30.327868852459, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=265, Percent_Identity=25.2830188679245, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=47.2636815920398, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24662918, Length=372, Percent_Identity=35.2150537634409, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17136286, Length=354, Percent_Identity=28.2485875706215, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24653280, Length=269, Percent_Identity=25.2788104089219, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653276, Length=269, Percent_Identity=25.2788104089219, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653278, Length=269, Percent_Identity=25.2788104089219, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44560; Mature: 44560

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYSQYFSAALGRLHDERRYRVFADLERIAGRFPHATWHSPNGPRNVVIWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPKVVGAMVETATRVGTGAGGTRNIAGTHHPLVQLEAELADLHGKEAALLFTSGYVSNQT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCH
GIATLAKLIPDCLILSDALNHNSMIEGVRQSGCERQIWRHNDLAHLEQLLIAAGPSRPKL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCCE
IACESLYSMDGDVAPLAAICDLAERYNAMTYVDEVHAVGMYGARGGGIAERDGVMHRIDI
EEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHH
LEGTLAKAFGCLGGYIAAKGEIIDAVRSYAPGFIFTTALPPPICSAATAAIKHLKSSSWE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCHH
RERHQDRAARVKAILNAAGLPVMDNDTHIVPLFVGDPEKCKQASDLLLEEHGIYIQPINY
HHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVAKGTERLRITPSPYHDDGLIDRLAEALLQVWERLGLALHKKPLAAE
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCC
>Mature Secondary Structure
MDYSQYFSAALGRLHDERRYRVFADLERIAGRFPHATWHSPNGPRNVVIWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPKVVGAMVETATRVGTGAGGTRNIAGTHHPLVQLEAELADLHGKEAALLFTSGYVSNQT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCH
GIATLAKLIPDCLILSDALNHNSMIEGVRQSGCERQIWRHNDLAHLEQLLIAAGPSRPKL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCCE
IACESLYSMDGDVAPLAAICDLAERYNAMTYVDEVHAVGMYGARGGGIAERDGVMHRIDI
EEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHH
LEGTLAKAFGCLGGYIAAKGEIIDAVRSYAPGFIFTTALPPPICSAATAAIKHLKSSSWE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCHH
RERHQDRAARVKAILNAAGLPVMDNDTHIVPLFVGDPEKCKQASDLLLEEHGIYIQPINY
HHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVAKGTERLRITPSPYHDDGLIDRLAEALLQVWERLGLALHKKPLAAE
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]