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The map label for this gene is pkn1 [H]

Identifier: 146343110

GI number: 146343110

Start: 6555072

End: 6556529

Strand: Direct

Name: pkn1 [H]

Synonym: BRADO6307

Alternate gene names: 146343110

Gene position: 6555072-6556529 (Clockwise)

Preceding gene: 146343109

Following gene: 146343111

Centisome position: 87.91

GC content: 69.89

Gene sequence:

>1458_bases
ATGAGCGAGAGTTCAGCATTGCAATGGCTGCGGGCGCCGAAGCTCGCGGAGGATACGCTGCCGATGGACTCGCGCACGGT
CGCCTGCCGGCGCTGCGGCCGCACCGTGGAGGTGTCGCTCAGCCCGATGCGCCCGCCCGGCTTCCTTCGCATCGAGGACC
AGGTCGAATGCCCCGAGGTGCAGGAGCGCTGGACGGGCAAGGACCAGGGCGGTTTGCTGCTGATGATGTGCGGCGCGCTC
GAGCAGTCGCTCGACGCCGAATGGGAGATGGCGGAGGTCGAGGCGGCGACCGCGCATGAGCCGCCGCCGATCGTTGCTCC
GACCCCGCCGCACGCGGCGCCAGAGCTGATCGATGCCCTGCAGGACAGATGGAACGACGATCATGACGATGATCGGCAGG
TCGTATCCTCGACCGGCCGGCTGGCCAAGCTGCGTGCAGGATCCGCGCGGTTGCGCAAGGGAGCGGTGCGCGCCGTCGTG
GCGGTCTCGATCCTCGGCGTGGTCTTTCTCGGCGGGGTGCTGCTGCCGCTGCGCGAGATCAGGCTGCTGATCCAGACGCC
GCCCGGCGGCCTGGCCGCGTCGTCGAGCGCACCGCGCGACGCGCTCTCCGCGCCGCCGACCTCGCCGCGCCGCATCCTTT
CGGAAAGTGCAGCCACACCGCCTGGCGGCCAGCAAGTGCAAAGCACCTTCGTTCCGCCGCGTCCGGCGGCCGGCGCTGAC
ATGGCGTCAGTGCCCGCTGAGCCCGTCGCGGCGCCGCGTCCCGCCCCGGAGCCGGAGCCGAAGCTGCGCGTGCCCGAACT
GATCGCGGTCGCCGGCGGCAACTTCGCGATGGGCGGCGACGACGAGTCCGAGCAGCCGGTGCACCAGGTCAGCATCAAGC
CGTTCTCGCTCGGCAAGCATCCGGTGACCGTCGGCGAGTGGAAGAGTTGCGTGGCCGCGGCCAGCTGTCCCGACATCGCC
ATCGGCCCCGACGATCGGCCGGTCGTGAATGTCAGCTATGACGATACGCAGGCCTATCTGGCCTGGCTCTCGCGGGCGAC
CGGCAAGACGTTCCGCCTGCCGACCGAGGCCGAGTGGGAATATGCAGCGCGCGCCGGTCAGCGCACCCGCTACTGGTGGG
GCGATCGCATGCGCCAGGGCATGGCCAGCTGCAGGGGCTGCAACGGCGACGCGGAGTTGGATCTGCCGCCGAAGATTGCC
AGCACGCAGGTCAATCCGTTCGGTCTTCATGACATGGGCGGCGGGGTCGGCCAGTGGGTCGCCGACTCCTGGCACAAGAA
CTACAAGGGCGCGCCTGCCGATGGATCGGCCTGGCTCGAGGACGGCAGCTACGCCCGCGTCATCCGCTCCGGATCCTGGA
AGAATGGTCCGTCGGATGCGCGCGCCGGAAGCCGCGACCGCTACGATGGGCGCATCCGGCATCCGACCTTGGGCTTCCGC
GTCGCATCGTCATCATAG

Upstream 100 bases:

>100_bases
TGTCGATCGAGAAGGGCAGCGAGGGCGAGCGCGTGTTCAAGGACGCCTTCGCCAGCTGGGGTCAGTGAGCGGATTTGCAG
CGTCGCGAGGCGAGGACGGC

Downstream 100 bases:

>100_bases
GGGATCTGAATGAAGCGGACCACATCTCGACGTCTCTGCCTGATCCTGACCTTGTCGCTCGCGCTCGTGCCCTCGCTCTC
CTGGTCCAAGGGCACCAAGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSESSALQWLRAPKLAEDTLPMDSRTVACRRCGRTVEVSLSPMRPPGFLRIEDQVECPEVQERWTGKDQGGLLLMMCGAL
EQSLDAEWEMAEVEAATAHEPPPIVAPTPPHAAPELIDALQDRWNDDHDDDRQVVSSTGRLAKLRAGSARLRKGAVRAVV
AVSILGVVFLGGVLLPLREIRLLIQTPPGGLAASSSAPRDALSAPPTSPRRILSESAATPPGGQQVQSTFVPPRPAAGAD
MASVPAEPVAAPRPAPEPEPKLRVPELIAVAGGNFAMGGDDESEQPVHQVSIKPFSLGKHPVTVGEWKSCVAAASCPDIA
IGPDDRPVVNVSYDDTQAYLAWLSRATGKTFRLPTEAEWEYAARAGQRTRYWWGDRMRQGMASCRGCNGDAELDLPPKIA
STQVNPFGLHDMGGGVGQWVADSWHKNYKGAPADGSAWLEDGSYARVIRSGSWKNGPSDARAGSRDRYDGRIRHPTLGFR
VASSS

Sequences:

>Translated_485_residues
MSESSALQWLRAPKLAEDTLPMDSRTVACRRCGRTVEVSLSPMRPPGFLRIEDQVECPEVQERWTGKDQGGLLLMMCGAL
EQSLDAEWEMAEVEAATAHEPPPIVAPTPPHAAPELIDALQDRWNDDHDDDRQVVSSTGRLAKLRAGSARLRKGAVRAVV
AVSILGVVFLGGVLLPLREIRLLIQTPPGGLAASSSAPRDALSAPPTSPRRILSESAATPPGGQQVQSTFVPPRPAAGAD
MASVPAEPVAAPRPAPEPEPKLRVPELIAVAGGNFAMGGDDESEQPVHQVSIKPFSLGKHPVTVGEWKSCVAAASCPDIA
IGPDDRPVVNVSYDDTQAYLAWLSRATGKTFRLPTEAEWEYAARAGQRTRYWWGDRMRQGMASCRGCNGDAELDLPPKIA
STQVNPFGLHDMGGGVGQWVADSWHKNYKGAPADGSAWLEDGSYARVIRSGSWKNGPSDARAGSRDRYDGRIRHPTLGFR
VASSS
>Mature_484_residues
SESSALQWLRAPKLAEDTLPMDSRTVACRRCGRTVEVSLSPMRPPGFLRIEDQVECPEVQERWTGKDQGGLLLMMCGALE
QSLDAEWEMAEVEAATAHEPPPIVAPTPPHAAPELIDALQDRWNDDHDDDRQVVSSTGRLAKLRAGSARLRKGAVRAVVA
VSILGVVFLGGVLLPLREIRLLIQTPPGGLAASSSAPRDALSAPPTSPRRILSESAATPPGGQQVQSTFVPPRPAAGADM
ASVPAEPVAAPRPAPEPEPKLRVPELIAVAGGNFAMGGDDESEQPVHQVSIKPFSLGKHPVTVGEWKSCVAAASCPDIAI
GPDDRPVVNVSYDDTQAYLAWLSRATGKTFRLPTEAEWEYAARAGQRTRYWWGDRMRQGMASCRGCNGDAELDLPPKIAS
TQVNPFGLHDMGGGVGQWVADSWHKNYKGAPADGSAWLEDGSYARVIRSGSWKNGPSDARAGSRDRYDGRIRHPTLGFRV
ASSS

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194248087, Length=271, Percent_Identity=27.6752767527675, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI194248088, Length=286, Percent_Identity=26.2237762237762, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 52069; Mature: 51938

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSALQWLRAPKLAEDTLPMDSRTVACRRCGRTVEVSLSPMRPPGFLRIEDQVECPEV
CCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCHH
QERWTGKDQGGLLLMMCGALEQSLDAEWEMAEVEAATAHEPPPIVAPTPPHAAPELIDAL
HHHCCCCCCCCEEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
QDRWNDDHDDDRQVVSSTGRLAKLRAGSARLRKGAVRAVVAVSILGVVFLGGVLLPLREI
HHHCCCCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RLLIQTPPGGLAASSSAPRDALSAPPTSPRRILSESAATPPGGQQVQSTFVPPRPAAGAD
EEEEECCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCC
MASVPAEPVAAPRPAPEPEPKLRVPELIAVAGGNFAMGGDDESEQPVHQVSIKPFSLGKH
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHEEECCEEECCCC
PVTVGEWKSCVAAASCPDIAIGPDDRPVVNVSYDDTQAYLAWLSRATGKTFRLPTEAEWE
CCCHHHHHHHHHHCCCCCCEECCCCCCEEEEECCHHHHHHHHHHHHCCCEEECCCCCCHH
YAARAGQRTRYWWGDRMRQGMASCRGCNGDAELDLPPKIASTQVNPFGLHDMGGGVGQWV
HHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHCCCCHHHHH
ADSWHKNYKGAPADGSAWLEDGSYARVIRSGSWKNGPSDARAGSRDRYDGRIRHPTLGFR
HHHHHHCCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCHHCCCCCCCCCCEECCCCCEEE
VASSS
ECCCC
>Mature Secondary Structure 
SESSALQWLRAPKLAEDTLPMDSRTVACRRCGRTVEVSLSPMRPPGFLRIEDQVECPEV
CCHHHHHHHHCCCCHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCHH
QERWTGKDQGGLLLMMCGALEQSLDAEWEMAEVEAATAHEPPPIVAPTPPHAAPELIDAL
HHHCCCCCCCCEEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
QDRWNDDHDDDRQVVSSTGRLAKLRAGSARLRKGAVRAVVAVSILGVVFLGGVLLPLREI
HHHCCCCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RLLIQTPPGGLAASSSAPRDALSAPPTSPRRILSESAATPPGGQQVQSTFVPPRPAAGAD
EEEEECCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCC
MASVPAEPVAAPRPAPEPEPKLRVPELIAVAGGNFAMGGDDESEQPVHQVSIKPFSLGKH
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHEEECCEEECCCC
PVTVGEWKSCVAAASCPDIAIGPDDRPVVNVSYDDTQAYLAWLSRATGKTFRLPTEAEWE
CCCHHHHHHHHHHCCCCCCEECCCCCCEEEEECCHHHHHHHHHHHHCCCEEECCCCCCHH
YAARAGQRTRYWWGDRMRQGMASCRGCNGDAELDLPPKIASTQVNPFGLHDMGGGVGQWV
HHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHCCCCHHHHH
ADSWHKNYKGAPADGSAWLEDGSYARVIRSGSWKNGPSDARAGSRDRYDGRIRHPTLGFR
HHHHHHCCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCHHCCCCCCCCCCEECCCCCEEE
VASSS
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]