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The map label for this gene is hflC [H]

Identifier: 146342415

GI number: 146342415

Start: 5758411

End: 5759352

Strand: Reverse

Name: hflC [H]

Synonym: BRADO5574

Alternate gene names: 146342415

Gene position: 5759352-5758411 (Counterclockwise)

Preceding gene: 146342416

Following gene: 146342414

Centisome position: 77.24

GC content: 66.24

Gene sequence:

>942_bases
ATGAGGTCCCCCGTCACAGGCATCGTTGCGCTGGTCATCGCCCTCGCGCTCGTCGTCATCGGCTACAGCTCGCTGTTCAC
GGTGGCACAGACGGAGCAGGCGCTCGTTGTGCGGTTCGGCAAGCCGGTCGATGTCGTCACCGAGCCCGGGCTGAACGTCA
AGGCGCCGTTCATCGACAACGTGATCCTGATCGACAAGCGCATTCTCGACCTCGAAAATCCGTCGCAGGAGGTCATCGCC
TTCGACCAGAAGCGGCTGGTGGTCGACGCCTTCGCGCGCTACCGGATCAAGAACGCGCTGCAGTTCTATCAGCGAGCCGG
CACGATCCAGAACGCGAACGTCCAGCTTGGCACCTTGCTCAACGCGGCCCTGCGCCGCGTGCTCGGCGAGGTCACGTTCA
CCCAGGTCGTGCGCGACGAGCGCGAGACCTTGATGCGCAAGATTCGCGACCAGCTCGATCGGGAGGCTGACGCCTACGGC
ATTCAGGTGGTCGACGTTCGCATTCGTCGTGCCGACCTCCCCGAGGCCAACAGCCAAGCGGTTTACGATCGCATGAACAG
CGAGCGGCAACGTGAGGCGGCCGAGTTCCGGGCTCTCGGCGGCCAGAAGGCGCAGGAGATCAGGTCCAAGGCCGATCGCG
AGGCGACCGTGATCGTCGCCGAGGCGAACTCGCAGGCCGAGCAGACCCGCGGTGCCGGCGACGCCGAGCGCAATCGGCTG
TTCGCCGAGGCCTACGGCAAGGATCCCGATTTCTTCGCCTTCTACCGCTCGATGACGGCCTATGAGACCGGCCTGAAGTC
CGGCGACACCCGCTTCCTGCTGCGGCCGGATTCCGAGTTCTTCCGCTACTTCGCCAATCCCTCGGGGAAGGCGGCGGCGG
GACCGGAGACGCCGTCGGCCGCCAGCGCAACCGCGGCGGCGGCACAGGCCGCGAAACCCTGA

Upstream 100 bases:

>100_bases
TCGATGGCGGCCCCGGCGGTCCCGTGCCGCTGCTGCCGCTCGGCGATCTCGCGCCGCGGCGCCAGGCCGCCCCGAGCACC
ACGCAGCAGGGAGGCGTCCG

Downstream 100 bases:

>100_bases
GGTCGCCGGGCGGTTGTTGCCGGCGAATAAGAGTTGACACGGACGGGGCGAAGCCGTTGCTTCGCCCCGTCTGATATCAA
GAAGGTCAAACGGGAGGTCC

Product: protease activity modulator HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MRSPVTGIVALVIALALVVIGYSSLFTVAQTEQALVVRFGKPVDVVTEPGLNVKAPFIDNVILIDKRILDLENPSQEVIA
FDQKRLVVDAFARYRIKNALQFYQRAGTIQNANVQLGTLLNAALRRVLGEVTFTQVVRDERETLMRKIRDQLDREADAYG
IQVVDVRIRRADLPEANSQAVYDRMNSERQREAAEFRALGGQKAQEIRSKADREATVIVAEANSQAEQTRGAGDAERNRL
FAEAYGKDPDFFAFYRSMTAYETGLKSGDTRFLLRPDSEFFRYFANPSGKAAAGPETPSAASATAAAAQAAKP

Sequences:

>Translated_313_residues
MRSPVTGIVALVIALALVVIGYSSLFTVAQTEQALVVRFGKPVDVVTEPGLNVKAPFIDNVILIDKRILDLENPSQEVIA
FDQKRLVVDAFARYRIKNALQFYQRAGTIQNANVQLGTLLNAALRRVLGEVTFTQVVRDERETLMRKIRDQLDREADAYG
IQVVDVRIRRADLPEANSQAVYDRMNSERQREAAEFRALGGQKAQEIRSKADREATVIVAEANSQAEQTRGAGDAERNRL
FAEAYGKDPDFFAFYRSMTAYETGLKSGDTRFLLRPDSEFFRYFANPSGKAAAGPETPSAASATAAAAQAAKP
>Mature_313_residues
MRSPVTGIVALVIALALVVIGYSSLFTVAQTEQALVVRFGKPVDVVTEPGLNVKAPFIDNVILIDKRILDLENPSQEVIA
FDQKRLVVDAFARYRIKNALQFYQRAGTIQNANVQLGTLLNAALRRVLGEVTFTQVVRDERETLMRKIRDQLDREADAYG
IQVVDVRIRRADLPEANSQAVYDRMNSERQREAAEFRALGGQKAQEIRSKADREATVIVAEANSQAEQTRGAGDAERNRL
FAEAYGKDPDFFAFYRSMTAYETGLKSGDTRFLLRPDSEFFRYFANPSGKAAAGPETPSAASATAAAAQAAKP

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=175, Percent_Identity=29.1428571428571, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI7305503, Length=222, Percent_Identity=25.6756756756757, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI21686995, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI221316744, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1790617, Length=314, Percent_Identity=33.7579617834395, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786697, Length=286, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790616, Length=209, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71987621, Length=238, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25153583, Length=244, Percent_Identity=28.2786885245902, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71987612, Length=238, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32564147, Length=222, Percent_Identity=27.4774774774775, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193209764, Length=171, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17569493, Length=171, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32566490, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45556022, Length=243, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45550506, Length=216, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657857, Length=247, Percent_Identity=28.3400809716599, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281365664, Length=247, Percent_Identity=28.3400809716599, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI62484448, Length=247, Percent_Identity=28.3400809716599, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI62484274, Length=247, Percent_Identity=28.3400809716599, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18860517, Length=173, Percent_Identity=28.9017341040462, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 34567; Mature: 34567

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPVTGIVALVIALALVVIGYSSLFTVAQTEQALVVRFGKPVDVVTEPGLNVKAPFIDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCEECCCCCC
VILIDKRILDLENPSQEVIAFDQKRLVVDAFARYRIKNALQFYQRAGTIQNANVQLGTLL
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NAALRRVLGEVTFTQVVRDERETLMRKIRDQLDREADAYGIQVVDVRIRRADLPEANSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCEEEEEEEEEECCCCCCCHHH
VYDRMNSERQREAAEFRALGGQKAQEIRSKADREATVIVAEANSQAEQTRGAGDAERNRL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHCCCCCHHHHHH
FAEAYGKDPDFFAFYRSMTAYETGLKSGDTRFLLRPDSEFFRYFANPSGKAAAGPETPSA
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCH
ASATAAAAQAAKP
HHHHHHHHHCCCC
>Mature Secondary Structure
MRSPVTGIVALVIALALVVIGYSSLFTVAQTEQALVVRFGKPVDVVTEPGLNVKAPFIDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCEECCCCCC
VILIDKRILDLENPSQEVIAFDQKRLVVDAFARYRIKNALQFYQRAGTIQNANVQLGTLL
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NAALRRVLGEVTFTQVVRDERETLMRKIRDQLDREADAYGIQVVDVRIRRADLPEANSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCEEEEEEEEEECCCCCCCHHH
VYDRMNSERQREAAEFRALGGQKAQEIRSKADREATVIVAEANSQAEQTRGAGDAERNRL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHCCCCCHHHHHH
FAEAYGKDPDFFAFYRSMTAYETGLKSGDTRFLLRPDSEFFRYFANPSGKAAAGPETPSA
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCH
ASATAAAAQAAKP
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]