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The map label for this gene is Dml [H]

Identifier: 146342352

GI number: 146342352

Start: 5690807

End: 5691685

Strand: Reverse

Name: Dml [H]

Synonym: BRADO5508

Alternate gene names: 146342352

Gene position: 5691685-5690807 (Counterclockwise)

Preceding gene: 146342353

Following gene: 146342351

Centisome position: 76.33

GC content: 67.69

Gene sequence:

>879_bases
ATGAGCCTGAGATCCACTCTGGCATCCGCCGAGACGACGATCGCGCCTGGCGTGTACGATGCGCTGACCGCGAGCATTGC
CGTCGAGGCCGGCTTCAACGCGCTGTACCTGACTGGCGCGGGCATCGCTTACACGAAGCTCGGCCGTCCCGACATCGGCC
TGGTGTCGATGATGGAGGTCGCCGACACCATCGCCATGATCCGCGACCGCGTCGACGTGCCGCTGGTGGTCGACGCCGAC
ACCGGCTTCGGCAATGCGCTCAACGTGCAGCGGACAGTGCGGCTGTTCGAGCGCATGGGCGCCTCGGCGATCCAGCTCGA
GGACCAGACCACGCCGAAGCGCTGCGGCCATCTCACCGACAAGACCGTGATCAGCGCGAGCGAGATGGTCGGCAAGATCA
AGGCCGCTCTCGACGCCCGGCAGTCCGCCGAGACCTTGATCGTCGCGCGTACCGATGCGCTGGCGATCGAGGGCATGGAG
GCCGCGATCGAACGCGCCGAGCGCTATGCCGAGGCAGGCGCCGACGTGCTGTTCGTCGAGGCGCCGAAGAGCAATGAGCA
GTTGTCCGCGATCGCTGGCCGTCTCGCGTCGAAGCGGCCGCTGCTCGCCAACATGGTCGAGGGCGGCTCGACGCCGATCC
ATGCGGCCTCAGAGCTCGGCGCGCTCGGCTTCAAGCTCGTGATCTTCCCCGGCGGCATCGTGCGCGCGCTCGCGTTCTCG
GCGCGGGCCTACTATCAGTCGCTGGCGCAGGCCGGCTCGACCAAGCCGTTCGCCGACCGCATGCTCGATTTCGCCGGTCT
CAACGCGATGCTCGGCACCGCCGATATCCTGGCGAACGGTGCCCGTTACGCAGCAGATGACGAGGGAACGCGGGCATGA

Upstream 100 bases:

>100_bases
ACCAGCTTCCGAGCTGAAATCCAATGCCGAGCTGAAGCGCGCCTATCTCGGTCTGTGACGTCAGATTCAGCGAACAGTTG
AGACAAACAAGGAAACGATA

Downstream 100 bases:

>100_bases
CCAACATGGATCCGATCACGCTCGCGGTGCTGAAGGGGCGGCTGGAGCAGATCGCCGACGAAATGGATGCGACGTTGTAC
CGCTCCGCGTTCAACCCGAC

Product: putative isocitrate lyase-family protein carboxyvinyl-carboxyphosphonate phosphorylmutase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSLRSTLASAETTIAPGVYDALTASIAVEAGFNALYLTGAGIAYTKLGRPDIGLVSMMEVADTIAMIRDRVDVPLVVDAD
TGFGNALNVQRTVRLFERMGASAIQLEDQTTPKRCGHLTDKTVISASEMVGKIKAALDARQSAETLIVARTDALAIEGME
AAIERAERYAEAGADVLFVEAPKSNEQLSAIAGRLASKRPLLANMVEGGSTPIHAASELGALGFKLVIFPGGIVRALAFS
ARAYYQSLAQAGSTKPFADRMLDFAGLNAMLGTADILANGARYAADDEGTRA

Sequences:

>Translated_292_residues
MSLRSTLASAETTIAPGVYDALTASIAVEAGFNALYLTGAGIAYTKLGRPDIGLVSMMEVADTIAMIRDRVDVPLVVDAD
TGFGNALNVQRTVRLFERMGASAIQLEDQTTPKRCGHLTDKTVISASEMVGKIKAALDARQSAETLIVARTDALAIEGME
AAIERAERYAEAGADVLFVEAPKSNEQLSAIAGRLASKRPLLANMVEGGSTPIHAASELGALGFKLVIFPGGIVRALAFS
ARAYYQSLAQAGSTKPFADRMLDFAGLNAMLGTADILANGARYAADDEGTRA
>Mature_291_residues
SLRSTLASAETTIAPGVYDALTASIAVEAGFNALYLTGAGIAYTKLGRPDIGLVSMMEVADTIAMIRDRVDVPLVVDADT
GFGNALNVQRTVRLFERMGASAIQLEDQTTPKRCGHLTDKTVISASEMVGKIKAALDARQSAETLIVARTDALAIEGMEA
AIERAERYAEAGADVLFVEAPKSNEQLSAIAGRLASKRPLLANMVEGGSTPIHAASELGALGFKLVIFPGGIVRALAFSA
RAYYQSLAQAGSTKPFADRMLDFAGLNAMLGTADILANGARYAADDEGTRA

Specific function: Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=246, Percent_Identity=42.2764227642276, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320908, Length=106, Percent_Identity=35.8490566037736, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.32 [H]

Molecular weight: Translated: 30601; Mature: 30470

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRSTLASAETTIAPGVYDALTASIAVEAGFNALYLTGAGIAYTKLGRPDIGLVSMMEV
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCHHHHHHHH
ADTIAMIRDRVDVPLVVDADTGFGNALNVQRTVRLFERMGASAIQLEDQTTPKRCGHLTD
HHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCH
KTVISASEMVGKIKAALDARQSAETLIVARTDALAIEGMEAAIERAERYAEAGADVLFVE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
APKSNEQLSAIAGRLASKRPLLANMVEGGSTPIHAASELGALGFKLVIFPGGIVRALAFS
CCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHH
ARAYYQSLAQAGSTKPFADRMLDFAGLNAMLGTADILANGARYAADDEGTRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLRSTLASAETTIAPGVYDALTASIAVEAGFNALYLTGAGIAYTKLGRPDIGLVSMMEV
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCHHHHHHHH
ADTIAMIRDRVDVPLVVDADTGFGNALNVQRTVRLFERMGASAIQLEDQTTPKRCGHLTD
HHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCH
KTVISASEMVGKIKAALDARQSAETLIVARTDALAIEGMEAAIERAERYAEAGADVLFVE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
APKSNEQLSAIAGRLASKRPLLANMVEGGSTPIHAASELGALGFKLVIFPGGIVRALAFS
CCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHH
ARAYYQSLAQAGSTKPFADRMLDFAGLNAMLGTADILANGARYAADDEGTRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA