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The map label for this gene is alsR [H]

Identifier: 146341706

GI number: 146341706

Start: 5009294

End: 5010292

Strand: Direct

Name: alsR [H]

Synonym: BRADO4811

Alternate gene names: 146341706

Gene position: 5009294-5010292 (Clockwise)

Preceding gene: 146341699

Following gene: 146341707

Centisome position: 67.18

GC content: 69.77

Gene sequence:

>999_bases
ATGGAGCTGCGCCTGTTTCGCTACTGCGTCGCCGTTGCCGAGGAAGCGAGCTTCACGCGCGCGGCGGCGCGGTTGCGGAT
TGCGCAGCCGGCGCTGAGCCGGCAGATCAAGGCGGTCGAGCAGGAGATCGGCTTTGCGCTGTTCCAACGCGGCCTGCGCG
GCGTCACGCTGACGGAGGCTGGGCGCGTACTGATCGCGAGCGCGCGCAGCGTGCTGGCCGAAGCCGAGGCCGCGGTGCAG
AAGGCGCGGCGCGCCGGCCGCGGCGAGCTCGGGCTGCTCCGGATCGGCTTCACCGCCTCCGCCTCGTTCAATCCGTTCGT
GACCGGCGCGATCCGTGATTTCCGTACCGCCTATCCCGACGTCGAGATCGAACTGATCGAGGAGGCCACCAGCTTCCTGC
TCGAGCGCTTCGCCAACGGCCGGCTCGACGTCGCCTTCATCCGACCGGCTCCCGGCGAGGTGGACCATCTGCTCTCGCAG
CGCGCCGTCACGGAGCCGTTGGTCGTCGCGATGCCGAGCGCGCACAAGCAGGCGGCGCGCAAATCCGTTGCGCTGGCCTC
GCTCGCCGACGACGCCTTCATTCTGTACCCGCGCCCGAACGGCCGCGCGCTGTTCGACAGCATCGTCTCGGCCTGCCAGG
CCGCCGGCTTCTCGCCGAAGATTCTGCAGGTCGCGCCGCAACTCACCTCGGTGGTCAACCTCGTCGCCACCGGAATCGGA
GTCTCGATCGTGCCGCGCTCGATGGCGCAGGTGTCGACCGACGGCGTGGTCTATCGTCCCCTCACCCACGCACCCAAGGC
CGAGATCACACTGGTCCGGCGCAACCAGGCGGAGCCGCGCTCGGCCGTGCTGTTCGCCGACCTGGTGCGGTCGCGGGCAT
CGGCGTCCGCGGAGCTCTCATCGAAAGACCCGGGCGAAATCCGGCCGATACCCAGGAAAGATCACAGCCCCGCAAAACGG
AAGCCGGACAAGCCGACCCGGGCCGGTCGGCGCCGCTGA

Upstream 100 bases:

>100_bases
CACAGCGTTCGCCGGGACGACGATCGGAGAGACGTTGCCGCCGCGGACAAGGTCGTGACGCCGCGGCACGGGCACGACTG
ATGAGTTGTTAGGAGCCCCC

Downstream 100 bases:

>100_bases
TAAAACCGGCGACCGTCGCGGGCTGCCCGACGGGCAGCTCATGCCGATGCCACAATCCTGCGAGGCGCGCCGAAGTCCGT
GCTCGAAAAATGTCATTTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MELRLFRYCVAVAEEASFTRAAARLRIAQPALSRQIKAVEQEIGFALFQRGLRGVTLTEAGRVLIASARSVLAEAEAAVQ
KARRAGRGELGLLRIGFTASASFNPFVTGAIRDFRTAYPDVEIELIEEATSFLLERFANGRLDVAFIRPAPGEVDHLLSQ
RAVTEPLVVAMPSAHKQAARKSVALASLADDAFILYPRPNGRALFDSIVSACQAAGFSPKILQVAPQLTSVVNLVATGIG
VSIVPRSMAQVSTDGVVYRPLTHAPKAEITLVRRNQAEPRSAVLFADLVRSRASASAELSSKDPGEIRPIPRKDHSPAKR
KPDKPTRAGRRR

Sequences:

>Translated_332_residues
MELRLFRYCVAVAEEASFTRAAARLRIAQPALSRQIKAVEQEIGFALFQRGLRGVTLTEAGRVLIASARSVLAEAEAAVQ
KARRAGRGELGLLRIGFTASASFNPFVTGAIRDFRTAYPDVEIELIEEATSFLLERFANGRLDVAFIRPAPGEVDHLLSQ
RAVTEPLVVAMPSAHKQAARKSVALASLADDAFILYPRPNGRALFDSIVSACQAAGFSPKILQVAPQLTSVVNLVATGIG
VSIVPRSMAQVSTDGVVYRPLTHAPKAEITLVRRNQAEPRSAVLFADLVRSRASASAELSSKDPGEIRPIPRKDHSPAKR
KPDKPTRAGRRR
>Mature_332_residues
MELRLFRYCVAVAEEASFTRAAARLRIAQPALSRQIKAVEQEIGFALFQRGLRGVTLTEAGRVLIASARSVLAEAEAAVQ
KARRAGRGELGLLRIGFTASASFNPFVTGAIRDFRTAYPDVEIELIEEATSFLLERFANGRLDVAFIRPAPGEVDHLLSQ
RAVTEPLVVAMPSAHKQAARKSVALASLADDAFILYPRPNGRALFDSIVSACQAAGFSPKILQVAPQLTSVVNLVATGIG
VSIVPRSMAQVSTDGVVYRPLTHAPKAEITLVRRNQAEPRSAVLFADLVRSRASASAELSSKDPGEIRPIPRKDHSPAKR
KPDKPTRAGRRR

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=263, Percent_Identity=38.7832699619772, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI2367136, Length=275, Percent_Identity=32.3636363636364, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788887, Length=264, Percent_Identity=38.2575757575758, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1790399, Length=286, Percent_Identity=31.4685314685315, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI157672245, Length=290, Percent_Identity=29.6551724137931, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788297, Length=147, Percent_Identity=34.6938775510204, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=306, Percent_Identity=26.797385620915, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI145693105, Length=246, Percent_Identity=27.2357723577236, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787601, Length=285, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789506, Length=241, Percent_Identity=25.3112033195021, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790262, Length=253, Percent_Identity=26.4822134387352, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787530, Length=252, Percent_Identity=25.3968253968254, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787589, Length=133, Percent_Identity=35.3383458646617, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786401, Length=149, Percent_Identity=36.241610738255, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790208, Length=262, Percent_Identity=25.9541984732824, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787806, Length=258, Percent_Identity=24.8062015503876, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789639, Length=235, Percent_Identity=25.531914893617, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35921; Mature: 35921

Theoretical pI: Translated: 11.17; Mature: 11.17

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRLFRYCVAVAEEASFTRAAARLRIAQPALSRQIKAVEQEIGFALFQRGLRGVTLTEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHC
GRVLIASARSVLAEAEAAVQKARRAGRGELGLLRIGFTASASFNPFVTGAIRDFRTAYPD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCC
VEIELIEEATSFLLERFANGRLDVAFIRPAPGEVDHLLSQRAVTEPLVVAMPSAHKQAAR
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHH
KSVALASLADDAFILYPRPNGRALFDSIVSACQAAGFSPKILQVAPQLTSVVNLVATGIG
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
VSIVPRSMAQVSTDGVVYRPLTHAPKAEITLVRRNQAEPRSAVLFADLVRSRASASAELS
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
SKDPGEIRPIPRKDHSPAKRKPDKPTRAGRRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MELRLFRYCVAVAEEASFTRAAARLRIAQPALSRQIKAVEQEIGFALFQRGLRGVTLTEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHC
GRVLIASARSVLAEAEAAVQKARRAGRGELGLLRIGFTASASFNPFVTGAIRDFRTAYPD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCC
VEIELIEEATSFLLERFANGRLDVAFIRPAPGEVDHLLSQRAVTEPLVVAMPSAHKQAAR
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHH
KSVALASLADDAFILYPRPNGRALFDSIVSACQAAGFSPKILQVAPQLTSVVNLVATGIG
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
VSIVPRSMAQVSTDGVVYRPLTHAPKAEITLVRRNQAEPRSAVLFADLVRSRASASAELS
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
SKDPGEIRPIPRKDHSPAKRKPDKPTRAGRRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]